eLife

Latest preprint reviews

1. Calcium and bicarbonate signaling pathways have pivotal, resonating roles in matching ATP production to demand

   This article has 8 authors:

   1. Maura Greiser
   2. Mariusz Karbowski
   3. Aaron David Kaplan
   4. Andrew Kyle Coleman
   5. Nicolas Verhoeven
   6. Carmen A Mannella
   7. W Jonathan Lederer
   8. Liron Boyman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The important work presented here provides findings that substantially advance our understanding of a major research question into how bicarbonate/CO2 signaling regulates cardiac mitochondrial energy supply. The methods, data, and analyses broadly support the claims with only minor weaknesses concerning the exact spatial location of the enzymes involved. The work will be of broad interest to cell biologists and biochemists interested in metabolic control.

   Reviewed by eLife

2. Histone variants shape chromatin states in Arabidopsis

   This article has 9 authors:

   1. Bhagyshree Jamge
   2. Zdravko J Lorković
   3. Elin Axelsson
   4. Akihisa Osakabe
   5. Vikas Shukla
   6. Ramesh Yelagandula
   7. Svetlana Akimcheva
   8. Annika Luisa Kuehn
   9. Frédéric Berger

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents an important description on the dynamics of histone variant exchange controlling the organization of the chromatin state of the Arabidopsis genome, combining the analysis of histone variants, histone modification, and chromatin states. The evidence supporting the claims of the authors is compelling. This work will be of great interest to those in the field of epigenetics and chromatin biology.

   Reviewed by eLife

3. Substrate evaporation drives collective construction in termites

   This article has 5 authors:

   1. Giulio Facchini
   2. Alann Rathery
   3. Stéphane Douady
   4. David Sillam-Dussès
   5. Andrea Perna

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study investigates the environmental drivers behind termite construction, focusing, in particular, on pellet deposition behavior, with the conclusion that termites likely sense curvature indirectly through substrate evaporation. The findings reconcile discrepancies between previous studies through experimental and computational approaches. While the strength of the evidence supporting these claims is compelling, the authors do not discuss how their results affect our understanding of insect nest construction or animal-built structures more broadly.

   Reviewed by eLife

4. Independent regulation of Z-lines and M-lines during sarcomere assembly in cardiac myocytes revealed by the automatic image analysis software sarcApp

   This article has 8 authors:

   1. Abigail C Neininger-Castro
   2. James B Hayes
   3. Zachary C Sanchez
   4. Nilay Taneja
   5. Aidan M Fenix
   6. Satish Moparthi
   7. Stéphane Vassilopoulos
   8. Dylan Tyler Burnette

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript describes a useful tool for quantitative assessment of sarcomere structures in healthy and perturbed cardiomyocytes grown in vitro. The work is solid, and the methods, data and analyses broadly support the claims with only minor weaknesses. The tool will be relevant to biologists working on and interested in obtaining quantitative information on sarcomere structure, function and development.

   Reviewed by eLife

5. Brain age has limited utility as a biomarker for capturing fluid cognition in older individuals

   This article has 2 authors:

   1. Alina Tetereva
   2. Narun Pat

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This useful manuscript challenges the utility of current paradigms for estimating brain-age with magnetic resonance imaging measures. It presents solid evidence to support the suggestion that an alternative approach focused on predicting cognition may be more beneficial. This work will be of interest to researchers working on brain-age and related models.

   Reviewed by eLife

6. Extreme positive epistasis for fitness in monosomic yeast strains

   This article has 5 authors:

   1. Hanna Tutaj
   2. Katarzyna Tomala
   3. Adrian Pirog
   4. Marzena Marszałek
   5. Ryszard Korona

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study offers important insights into the generation and maintenance of monosomic yeast lines and is, to our knowledge, the first to evaluate gene expression in yeast monosomies. The research introduces an innovative method to assess epistasis between genes on the same chromosome, providing solid evidence for positive epistatic interactions affecting fitness. Although the authors have substantially improved the methodology and interpretation during revision, questions regarding the interpretation of the transcriptome data have not been completely addressed.

   Reviewed by eLife

7. A single-cell transcriptome atlas of pig skin characterizes anatomical positional heterogeneity

   This article has 18 authors:

   1. Qin Zou
   2. Rong Yuan
   3. Yu Zhang
   4. Yifei Wang
   5. Ting Zheng
   6. Rui Shi
   7. Mei Zhang
   8. Yujing Li
   9. Kaixin Fei
   10. Ran Feng
   11. Binyun Pan
   12. Xinyue Zhang
   13. Zhengyin Gong
   14. Li Zhu
   15. Guoqing Tang
   16. Mingzhou Li
   17. Xuewei Li
   18. Yanzhi Jiang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable manuscript provides a single-cell RNA sequencing analysis of adult pig skin from different species and anatomical regions. The evidence supporting the conclusions is compelling, with identification molecular and cellular differences in pig skin, yet the analyses are incomplete in the analysis of regional- or species-based differences.

   Reviewed by eLife

8. Tau polarizes an aging transcriptional signature to excitatory neurons and glia

   This article has 11 authors:

   1. Timothy Wu
   2. Jennifer M Deger
   3. Hui Ye
   4. Caiwei Guo
   5. Justin Dhindsa
   6. Brandon T Pekarek
   7. Rami Al-Ouran
   8. Zhandong Liu
   9. Ismael Al-Ramahi
   10. Juan Botas
   11. Joshua M Shulman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important study that defines cell type changes upon the expression of a mutant tau protein and put it into context of human postmortem tissue. Technically, the single cell mRNA sequencing data are convincing but the loss of neurons already at the earliest stages assessed in this model may rather suggest there are also elements of developmental toxicity.

   Reviewed by eLife

9. Homeodomain-interacting protein kinase maintains neuronal homeostasis during normal Caenorhabditis elegans aging and systemically regulates longevity from serotonergic and GABAergic neurons

   This article has 8 authors:

   1. Maria I Lazaro-Pena
   2. Adam B Cornwell
   3. Carlos A Diaz-Balzac
   4. Ritika Das
   5. Zachary C Ward
   6. Nicholas Macoretta
   7. Juilee Thakar
   8. Andrew V Samuelson

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study substantially advances our understanding of how aging and stress resilience across an organism is determined by identifying a new player in this process and uncovering its mode of action. The evidence is solid as the methods, data and analyses broadly support the claims with only minor weaknesses. The work will be of broad interest to the field of aging and protein homeostasis.

   Reviewed by eLife

10. Dopamine signaling regulates predator-driven changes in Caenorhabditis elegans’ egg laying behavior

    This article has 5 authors:

    1. Amy Pribadi
    2. Michael A Rieger
    3. Kaila Rosales
    4. Kirthi C Reddy
    5. Sreekanth H Chalasani

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      Studies of prey behavior have the potential to provide insight into the chemical encoding of stress in the brain and the mechanisms by which this generates behavioral plasticity. In this important work, the authors identify a novel predation-evoked behavior in the nematode C. elegans and implicate dopamine in its implementation. While the support for some claims in the current paper is incomplete, this work provides an exciting foundation for future studies of behavioral plasticity in this powerful system.

    Reviewed by eLife