Latest preprint reviews

  1. Chromatin and gene expression changes during female Drosophila germline stem cell development illuminate the biology of highly potent stem cells

    This article has 5 authors:
    1. Liang-Yu Pang
    2. Steven DeLuca
    3. Haolong Zhu
    4. John M Urban
    5. Allan C Spradling
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important work significantly advances our comprehension of the molecular events occurring during germline stem cell differentiation in the Drosophila melanogaster ovary. The conclusions are strongly supported by compelling evidence, including rigorous data sets and complementary whole-genome analyses. As a result, this research holds substantial interest for developmental and stem cell biologists alike.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  2. The Calpain-7 protease functions together with the ESCRT-III protein IST1 within the midbody to regulate the timing and completion of abscission

    This article has 7 authors:
    1. Elliott L Paine
    2. Jack J Skalicky
    3. Frank G Whitby
    4. Douglas R Mackay
    5. Katharine S Ullman
    6. Christopher P Hill
    7. Wesley I Sundquist
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The manuscript by Paine and coworkers provides a fundamental improvement on how the enzymatic activity of CALPAIN7 (a Cys protease) influences cytokinesis mediated by the ESCRT (endosomal sorting complexes required for transport) pathway. The authors provide a convincing molecular and cellular basis for one of the several key steps involved in membrane fission during the separation of dividing eukaryotic cells. These findings should be of interest to a wide scientific audience including biochemists, structural biologists, and cell biologists.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
  3. Lmx1a is a master regulator of the cortical hem

    This article has 8 authors:
    1. Igor Y Iskusnykh
    2. Nikolai Fattakhov
    3. Yiran Li
    4. Laure Bihannic
    5. Matthew K Kirchner
    6. Ekaterina Y Steshina
    7. Paul A Northcott
    8. Victor V Chizhikov
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important work advances our understanding of the generation of a main organizer of the vertebrate brain, the cortical hem. The authors convincingly show the contribution of multiple downstream effectors, each involved in specific processes regulated by the master gene, Lmx1a. This study has broader implications for how secondary organizers are created in the embryo and will be of interest to a wide readership.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  4. Systems level identification of a matrisome-associated macrophage polarisation state in multi-organ fibrosis

    This article has 7 authors:
    1. John F Ouyang
    2. Kunal Mishra
    3. Yi Xie
    4. Harry Park
    5. Kevin Y Huang
    6. Enrico Petretto
    7. Jacques Behmoaras
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study deepens our understanding of macrophage phenotypes in pathological contexts and identifies a new macrophage state associated with tissue fibrosis, as well as putative drivers of this cellular state. The authors provide convincing evidence and performed a well-thought-out and thoroughly described computational analysis of single-cell RNA-sequencing data. This work will be of broad interest to the fields of tissue inflammation, fibrosis, macrophage biology, and immunology.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
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