eLife

Latest preprint reviews

1. Mechanotransductive feedback control of endothelial cell motility and vascular morphogenesis

   This article has 14 authors:

   1. Devon E Mason
   2. Paula Camacho
   3. Megan E Goeckel
   4. Brendan R Tobin
   5. Sebastián L Vega
   6. Pei-Hsun Wu
   7. Dymonn Johnson
   8. Su-Jin Heo
   9. Denis Wirtz
   10. Jason A Burdick
   11. Levi Wood
   12. Brian Y Chow
   13. Amber N Stratman
   14. Joel D Boerckel

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This fundamental study substantially advances our current understanding of mechanotransduction within endothelial cells. The evidence provided by the authors in the revised manuscript is compelling, which taken together, provides strong support for the authors' major findings. The work will be of broad interest to cell biologists and vascular biologists.

   Reviewed by eLife

2. Self-formation of concentric zones of telencephalic and ocular tissues and directional retinal ganglion cell axons

   This article has 5 authors:

   1. Wei Liu
   2. Rupendra Shrestha
   3. Albert Lowe
   4. Xusheng Zhang
   5. Ludovic Spaeth

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this important study, the authors present a human telencephalon-eye organoid model that exhibits remarkable pathfinding and growth of retinal ganglion cell (RGC) axons. The identification of cell-surface markers for RGCs could have value for understanding the molecular mechanisms involved in RGC axon development and regeneration. The strength of evidence is compelling for future studies to investigate RGC neurite outgrowth and brain-eye connectivity in humans.

   Reviewed by eLife

3. Coevolution of the CDCA7-HELLS ICF-related nucleosome remodeling complex and DNA methyltransferases

   This article has 5 authors:

   1. Hironori Funabiki
   2. Isabel E Wassing
   3. Qingyuan Jia
   4. Ji-Dung Luo
   5. Thomas Carroll

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important manuscript reveals signatures of co-evolution of two nucleosome remodeling factors, Lsh/HELLS and CDCA7, which are involved in the regulation of eukaryotic DNA methylation. The results suggest that the roles for the two factors in DNA methylation maintenance pathways can be traced back to the last eukaryotic common ancestor and that the CDC7A-HELLS-DNMT axis shaped the evolutionary retention of DNA methylation in eukaryotes. The solid evolutionary analyses form a strong basis for experimental follow-up studies. The work should be of interest to colleagues in the fields of evolutionary biology, chromatin biology and genome biology.

   Reviewed by eLife

4. Hsf1 and the molecular chaperone Hsp90 support a ‘rewiring stress response’ leading to an adaptive cell size increase in chronic stress

   This article has 8 authors:

   1. Samarpan Maiti
   2. Kaushik Bhattacharya
   3. Diana Wider
   4. Dina Hany
   5. Olesya Panasenko
   6. Lilia Bernasconi
   7. Nicolas Hulo
   8. Didier Picard

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study describes the coordinated regulation of cellular size and protein translation in response to chronic stress as an adaptive mechanism, termed the 'rewiring stress response' regulated by the heat shock response. The evidence supporting this conclusion is solid, utilizing diverse methods to monitor and manipulate cell size and evaluate stress resistance. The study could be strengthened by the inclusion of more experiments focused on defining the mechanistic basis of this coordination and broadening the scope of the specific role of the 'rewiring stress response' across different chronic cellular stresses. This work will be of broad interest to researchers interested in diverse fields including cellular proteostasis, stress-responsive signaling, and aging and senescence.

   Reviewed by eLife

5. Metabolic regulation of misfolded protein import into mitochondria

   This article has 7 authors:

   1. Yuhao Wang
   2. Linhao Ruan
   3. Jin Zhu
   4. Xi Zhang
   5. Alexander Chih-Chieh Chang
   6. Alexis Tomaszewski
   7. Rong Li

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study makes a connection between cellular metabolism and proteostasis through MAGIC, a previously proposed protein quality control pathway of clearance of cytosolic misfolded and aggregated proteins by importing into mitochondria. The authors reveal the role of Snf1, a yeast AMPK, in preventing the import of misfolded proteins to mitochondria for MAGIC controlled by the transcription factor Hap4, depending on the cellular metabolic status. The key message is important, although the evidence for physiological relevance of MAGIC for overall cellular proteostasis and its molecular regulation by Snf1 remains incomplete.

   Reviewed by eLife, Life Science Editors Foundation

6. Binding to nucleosome poises human SIRT6 for histone H3 deacetylation

   This article has 5 authors:

   1. Ekaterina Smirnova
   2. Emmanuelle Bignon
   3. Patrick Schultz
   4. Gabor Papai
   5. Adam Ben Shem

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript provides a useful reconstruction of the structure of the sirtuin-class histone deacetylase Sirt6 bound to a nucleosome based on cryo-EM observations, and additional characterization of the flexibility of the histone tails in the complex based on molecular dynamics simulations. While similar structures have recently been published elsewhere, this solid study supports the conclusions of those papers and also includes new insights into the potential dynamics of Sirt6 bound to a nucleosome, insights that help explain its substrate specificity.

   Reviewed by eLife

7. Retinal input integration in excitatory and inhibitory neurons in the mouse superior colliculus in vivo

   This article has 3 authors:

   1. Carolin Gehr
   2. Jeremie Sibille
   3. Jens Kremkow

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study contributes to understanding how retinal activity shapes the response properties of excitatory and inhibitory neurons in a major visual target, the superior colliculus. The evidence supporting the claim is convincing: the work is technically excellent yet the interpretation of these results assumes an unbiased sampling and integration of the RGC axon in the SC, a caveat pointed out by the authors. Overall, this study provides insights into the integration of visual information from the eye to the brain, and this work will be of interest to visual neuroscientists.

   Reviewed by eLife

8. Intuitive movement-based prosthesis control enables arm amputees to reach naturally in virtual reality

   This article has 7 authors:

   1. Effie Segas
   2. Sébastien Mick
   3. Vincent Leconte
   4. Océane Dubois
   5. Rémi Klotz
   6. Daniel Cattaert
   7. Aymar de Rugy

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper is important because of its integration of movement and contextual information to control a virtual arm for individuals with upper-limb differences. The provided evidence convincingly demonstrates the approach's feasibility for manipulating a single object shape in different orientations within a virtual environment. However, additional improvements are needed for this proof-of-concept neuro-model to fulfil practical requirements.

   Reviewed by eLife

9. An acute microglial metabolic response controls metabolism and improves memory

   This article has 20 authors:

   1. Anne Drougard
   2. Eric H Ma
   3. Vanessa Wegert
   4. Ryan Sheldon
   5. Ilaria Panzeri
   6. Naman Vatsa
   7. Stefanos Apostle
   8. Luca Fagnocchi
   9. Judith Schaf
   10. Klaus Gossens
   11. Josephine Völker
   12. Shengru Pang
   13. Anna Bremser
   14. Erez Dror
   15. Francesca Giacona
   16. Sagar Sagar
   17. Michael X Henderson
   18. Marco Prinz
   19. Russell G Jones
   20. John Andrew Pospisilik

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study demonstrates a link between an acute high fat diet, microglial metabolism and improved higher cognitive function. The evidence supporting the proposed mechanism in vivo is incomplete at this stage due to non-trivial technical limitations but the authors provide convincing in vitro metabolic characterization of primary microglia cultures to support the model. This work will be of interest to a broad audience in the field of neuroscience, metabolism, and immunology.

   Reviewed by eLife

10. Integrin β4 promotes DNA damage-related drug resistance in triple-negative breast cancer via TNFAIP2/IQGAP1/RAC1

    This article has 11 authors:

    1. Huan Fang
    2. Wenlong Ren
    3. Qiuxia Cui
    4. Huichun Liang
    5. Chuanyu Yang
    6. Wenjing Liu
    7. Xinye Wang
    8. Xue Liu
    9. Yujie Shi
    10. Jing Feng
    11. Ceshi Chen

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This study presents a rather valuable finding that IQGAP1 interacts with TNFAIP2, which activates Rac1 to promote drug resistance in TNBC. The evidence supporting the claims of the authors is quite solid. The work will be of interest to scientists working on breast cancer.

    Reviewed by eLife