eLife

Latest preprint reviews

1. Key epigenetic and signaling factors in the formation and maintenance of the blood-brain barrier

   This article has 18 authors:

   1. Jayanarayanan Sadanandan
   2. Sithara Thomas
   3. Iny Elizabeth Mathew
   4. Zhen Huang
   5. Spiros L Blackburn
   6. Nitin Tandon
   7. Hrishikesh Lokhande
   8. Pierre D McCrea
   9. Emery H Bresnick
   10. Pramod K Dash
   11. Devin W McBride
   12. Arif Harmanci
   13. Lalit K Ahirwar
   14. Dania Jose
   15. Ari C Dienel
   16. Hussein A Zeineddine
   17. Sungha Hong
   18. Peeyush Kumar T

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The specific questions taken up for study by the authors-in mice of HDAC and Polycomb function in the context of vascular endothelial cell (EC) gene expression relevant to the blood-brain barrier, (BBB)-are potentially useful in the context of vascular diversification in understanding and remedying situations where BBB function is compromised. The strength of the evidence presented is incomplete, and to elaborate, it is known that the culturing of endothelial cells can have a strong effect on gene expression.

   Reviewed by eLife

2. A timeline of bacterial and archaeal diversification in the ocean

   This article has 3 authors:

   1. Carolina A Martinez-Gutierrez
   2. Josef C Uyeda
   3. Frank O Aylward

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important paper addresses the challenging problem of dating the origin of several groups of marine microorganisms. However, while much of the analyses are solid, the lack of robustness analysis in molecular dating component such as using alternative time calibrations, clock models, and input gene sets makes the study incomplete. Despite some concerns, this work is a commendable attempt at an extremely difficult problem and will be of broad interest to microbiologists, geologists, and evolutionary biologists.

   Reviewed by eLife

3. Ligand bias underlies differential signaling of multiple FGFs via FGFR1

   This article has 9 authors:

   1. Kelly Karl
   2. Nuala Del Piccolo
   3. Taylor Light
   4. Tanaya Roy
   5. Pooja Dudeja
   6. Vlad-Constantin Ursachi
   7. Bohumil Fafilek
   8. Pavel Krejci
   9. Kalina Hristova

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript describes useful data on the mechanisms underlying the activation of the receptor tyrosine kinase FGFR1 and stimulation of intracellular signaling pathways in response to FGF4, FGF8, or FGF9 binding to the extracellular domain of FGFR1. Solid evidence for quantitative differences in the downstream responses induced by the three ligands is presented. This manuscript will be of interest to biochemists and cell biologists working on receptor tyrosine kinases and general cell signalling across membranes.

   Reviewed by eLife

4. Continuous, long-term crawling behavior characterized by a robotic transport system

   This article has 9 authors:

   1. James Yu
   2. Stephanie Dancausse
   3. Maria Paz
   4. Tolu Faderin
   5. Melissa Gaviria
   6. Joseph W Shomar
   7. Dave Zucker
   8. Vivek Venkatachalam
   9. Mason Klein

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study describes a useful method to monitor the behavior of Drosophila larvae in a uniform environment over much longer time scales than was possible with previous methods. The authors provide a solid characterization of aspects of the method and show that the behavior of single larvae can be quantified over several hours. The experiments offer a proof-of-concept for a robotic device that will enable the investigation of behavior in long-term experiments in ways that were previously unimaginable.

   Reviewed by eLife

5. High-resolution volumetric imaging constrains compartmental models to explore synaptic integration and temporal processing by cochlear nucleus globular bushy cells

   This article has 8 authors:

   1. George A Spirou
   2. Matthew Kersting
   3. Sean Carr
   4. Bayan Razzaq
   5. Carolyna Yamamoto Alves Pinto
   6. Mariah Dawson
   7. Mark H Ellisman
   8. Paul B Manis

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript provides a structural analysis of bushy cells in the mouse cochlear nucleus. These neurons receive a large synaptic contact from the auditory nerve termed an endbulb that preserves the temporal information present in the auditory nerve and are key elements of binaural sound localization circuits. The analysis combines volume electron microscopy techniques with computational models to predict heterogeneous bushy cell responses. The analysis takes morphological analysis of bushy cells to a new level, and the modeling is well done.

   Reviewed by eLife

6. Interaction between Teneurin-2 and microtubules via EB proteins provides a platform for GABAA receptor exocytosis

   This article has 7 authors:

   1. Sotaro Ichinose
   2. Yoshihiro Susuki
   3. Nobutake Hosoi
   4. Ryosuke Kaneko
   5. Mizuho Ebihara
   6. Hirokazu Hirai
   7. Hirohide Iwasaki

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This potentially important paper investigates the mechanisms that contribute to building inhibitory synapses through differential protein release from microtubules. The experiments are generally designed well, but the evidence supporting the conclusions is incomplete. This manuscript will be of interest to neuroscientists and cell biologists interested in intracellular trafficking and synapse maturation.

   Reviewed by eLife

7. Amelioration of non-alcoholic fatty liver disease by targeting adhesion G protein-coupled receptor F1 (Adgrf1)

   This article has 12 authors:

   1. Mengyao Wu
   2. Tak-Ho Lo
   3. Liping Li
   4. Jia Sun
   5. Chujun Deng
   6. Ka-Ying Chan
   7. Xiang Li
   8. Steve Ting-Yuan Yeh
   9. Jimmy Tsz Hang Lee
   10. Pauline Po Yee Lui
   11. Aimin Xu
   12. Chi-Ming Wong

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     These valuable findings presented by Wu et al. advance our understanding in novel cell signaling regulators of hepatic metabolism. The evidence supporting these conclusions are solid, utilizing in vivo and in vitro gain and loss of function studies. These work will be of interest to biologists working in the field of hepatic steatosis.

   Reviewed by eLife

8. FAM76B regulates NF-κB-mediated inflammatory pathway by influencing the translocation of hnRNPA2B1

   This article has 9 authors:

   1. Dongyang Wang
   2. Xiaojing Zheng
   3. Lihong Chai
   4. Junli Zhao
   5. Jiuling Zhu
   6. Yanqing Li
   7. Peiyan Yang
   8. Qinwen Mao
   9. Haibin Xia

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The paper provides important insight into the function of FAM76B protein as a regulator of inflammation. The knockout/overexpression data are solid, however, the mechanism of regulation and the role of FAM76B in neurodegeneration is incomplete and requires additional experimentation. The work will be of interest to researchers studying inflammation, particularly neuroinflammation.

   Reviewed by eLife

9. Aerobic exercise reverses aging-induced depth-dependent decline in cerebral microcirculation

   This article has 18 authors:

   1. Paul Shin
   2. Qi Pian
   3. Hidehiro Ishikawa
   4. Gen Hamanaka
   5. Emiri T Mandeville
   6. Shuzhen Guo
   7. Buyin Fu
   8. Mohammed Alfadhel
   9. Srinivasa Rao Allu
   10. Ikbal Şencan-Eğilmez
   11. Baoqiang Li
   12. Chongzhao Ran
   13. Sergei A Vinogradov
   14. Cenk Ayata
   15. Eng Lo
   16. Ken Arai
   17. Anna Devor
   18. Sava Sakadžić

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study shows that exercise improves cerebrovascular function during aging using convincing methods, the authors show that aerobic exercise reverses aging-induced deficits in microvascular perfusion and oxygenation and potentially improves short-term memory. This work will be of broad interest to researchers and clinicians studying vascular function, age-related cognitive decline, and the effects of aerobic exercise on reversing age-related dysfunction.

   Reviewed by eLife

10. Biallelic variants in MAD2L1BP (p31comet) cause female infertility characterized by oocyte maturation arrest

    This article has 17 authors:

    1. Lingli Huang
    2. Wenqing Li
    3. Xingxing Dai
    4. Shuai Zhao
    5. Bo Xu
    6. Fengsong Wang
    7. Ren-Tao Jin
    8. Lihua Luo
    9. Limin Wu
    10. Xue Jiang
    11. Yu Cheng
    12. Jiaqi Zou
    13. Caoling Xu
    14. Xianhong Tong
    15. Heng-Yu Fan
    16. Han Zhao
    17. Jianqiang Bao

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This valuable study identifies three independent patient mutations in MAD2L1BP (p31 comet) that cause infertility. Consistent with the known functions of p31 comet, solid experiments in mouse oocytes imply that infertility could be caused by a failure to silence the spindle assembly checkpoint, though the mechanism was not determined. Although the sample size is small, a rescue experiment in human oocytes promises the potential for therapy.

    Reviewed by eLife