eLife

Latest preprint reviews

1. Allosteric regulation of kinase activity in living cells

   This article has 2 authors:

   1. Shivani Sujay Godbole
   2. Nikolay V Dokholyan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     One of the most promising strategies in development of drugs targeting kinases is provided by using allosteric control that allows specific regulation and study of kinase function without directly targeting the active site. This important paper reviews convincingly the current repertoire of tools for regulating the activity of protein kinases with the ultimate goal of developing novel approaches in treating diseases associated with signal dysregulation.

   Reviewed by eLife

2. We couldn't get details of this article at this time:
   10.1101/2023.08.15.553395

3. Adulis and the transshipment of baboons during classical antiquity

   This article has 12 authors:

   1. Franziska Grathwol
   2. Christian Roos
   3. Dietmar Zinner
   4. Benjamin Hume
   5. Stéphanie M Porcier
   6. Didier Berthet
   7. Jacques Cuisin
   8. Stefan Merker
   9. Claudio Ottoni
   10. Wim Van Neer
   11. Nathaniel J Dominy
   12. Gisela H Kopp

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This Research Advance provides compelling evidence connecting the ancient Egyptian trade of baboons with the ancient port city of Adulis. Combining ancient DNA methods from a single mummified baboon with historical accounts, this work fundamentally advances our understanding of the ancient baboon trade in the Red Sea. Some additional reporting of DNA contamination will make the evidence provided even stronger.

   Reviewed by eLife

4. Genomic stability of self-inactivating rabies

   This article has 6 authors:

   1. Ernesto Ciabatti
   2. Ana González-Rueda
   3. Daniel de Malmazet
   4. Hassal Lee
   5. Fabio Morgese
   6. Marco Tripodi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors previously developed a tool with the goal of non-toxic trans-synaptic tracing using a modified rabies virus, an important goal for the neuroscience field. The tool has the propensity to accumulate mutations over time that promote toxicity, and the manuscript here describes techniques to avoid these mutations. It remains important to show that the non-mutated virus can serve as an effective trans-synaptic tracing tool.

   Reviewed by eLife

5. Optogenetic activation of visual thalamus generates artificial visual percepts

   This article has 9 authors:

   1. Jing Wang
   2. Hamid Azimi
   3. Yilei Zhao
   4. Melanie Kaeser
   5. Pilar Vaca Sánchez
   6. Abraham Vazquez-Guardado
   7. John A Rogers
   8. Michael Harvey
   9. Gregor Rainer

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study shows that tree shrews can detect optogenetic stimulation of the lateral geniculate nucleus (LGN) after training detection of visual stimuli. The solid evidence links optogenetic stimulation of the LGN to behavioural detection and neurophysiological responses. This paper is potentially of interest to neuroscientists and clinicians working on the visual system and visual prostheses.

   Reviewed by eLife

6. We couldn't get details of this article at this time:
   10.1101/2023.02.28.530460

7. We couldn't get details of this article at this time:
   10.1101/2023.05.15.540704

8. We couldn't get details of this article at this time:
   10.1101/2023.05.02.538537

9. We couldn't get details of this article at this time:
   10.1101/2023.04.19.537519

10. We couldn't get details of this article at this time:
    10.1101/2023.03.17.533246