eLife

Latest preprint reviews

1. Astrocyte and L-lactate in the anterior cingulate cortex modulate schema memory and neuronal mitochondrial biogenesis

   This article has 9 authors:

   1. Mastura Akter
   2. Mahadi Hasan
   3. Aruna Surendran Ramkrishnan
   4. Zafar Iqbal
   5. Xianlin Zheng
   6. Zhongqi Fu
   7. Zhuogui Lei
   8. Anwarul Karim
   9. Ying Li

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important study that investigates the role of astrocytic Gi signaling in the anterior cingulate cortex in the modulation of extracellular L-lactate level and consequently impairment in flavor-place associates (PA) learning. However, whereas some of the behavioral observations and signaling mechanism data are compelling, the conclusions about effects on memory and the role of L-lactate are based on inadequate methods. With the addition of a few key experiments, this work will be of interest to neuroscientists studying learning and memory and the contribution of astrocytes to these processes.

   Reviewed by eLife

2. Single-cell sequencing highlights heterogeneity and malignant progression in actinic keratosis and cutaneous squamous cell carcinoma

   This article has 17 authors:

   1. Dan-Dan Zou
   2. Ya-Zhou Sun
   3. Xin-Jie Li
   4. Wen-Juan Wu
   5. Dan Xu
   6. Yu-Tong He
   7. Jue Qi
   8. Ying Tu
   9. Yang Tang
   10. Yun-Hua Tu
   11. Xiao-Li Wang
   12. Xing Li
   13. Feng-Yan Lu
   14. Ling Huang
   15. Heng Long
   16. Li He
   17. Xin Li

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study delineates the molecular changes driving the progression from actinic keratosis (AK) to cutaneous squamous cell carcinoma (cSCC). Using state-of-the-art single-cell RNA profiling of 138,982 cells from 13 samples of six patients including AK, squamous cell carcinoma in situ (SCCIS), cSCC, and their matched normal tissues, thus covering comprehensive clinical courses of cSCC, the authors provide an invaluable data resource. This study identified several previously unreported and interesting candidate genes involved in different stages of the malignant progression of skin neoplasias, which have been validated in situ, and partially in vitro. Although data analysis needs improvement and comparison to other published data sets to fully support the claims and conclusions, these findings substantially advance our understanding of the molecular changes leading to skin cancer.

   Reviewed by eLife

3. Homeostasis, injury, and recovery dynamics at multiple scales in a self-organizing mouse intestinal crypt

   This article has 9 authors:

   1. Louis Gall
   2. Carrie Duckworth
   3. Ferran Jardi
   4. Lieve Lammens
   5. Aimee Parker
   6. Ambra Bianco
   7. Holly Kimko
   8. David Mark Pritchard
   9. Carmen Pin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors developed a valuable mathematical model that describes the spatiotemporal dynamics of cells in the intestinal crypt. The proposed model makes an important contribution to the field, allowing a better understanding of the formation and response dynamics of the intestinal crypt through the effective evaluation of health, disease, and treatment conditions. The authors provided solid evidence of the validity of their model and their conclusions, but some minor claims are not properly justified in the current manuscript. This paper is meant for computational biologists and cancer researchers working on oncotherapies for the intestinal epithelium.

   Reviewed by eLife

4. We couldn't get details of this article at this time:
   10.1101/2023.07.13.548828

5. We couldn't get details of this article at this time:
   10.1101/2023.07.06.547975

6. We couldn't get details of this article at this time:
   10.1101/2023.06.15.545207

7. We couldn't get details of this article at this time:
   10.1101/2023.06.07.543871

8. We couldn't get details of this article at this time:
   10.1101/2022.06.16.495307

9. Exploring natural odour landscapes: A case study with implications for human-biting insects

   This article has 3 authors:

   1. Jessica L. Zung
   2. Sumer M. Kotb
   3. Carolyn S. McBride

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript provides a useful qualitative analysis of hair extracts from mammals, with the goal of understanding how mosquitoes encode the chemicals in the odor. The data were collected using standard spectrometric approaches in the field of chemical ecology, but they suffer from artifacts associated with the sampling approach and analyses, and are limited in their replicates and sampling which may prevent inter-species comparisons at this point. Without additional analysis, the evidence supporting the claims currently remains unfortunately incomplete.

   Reviewed by eLife

10. We couldn't get details of this article at this time:
    10.1101/2023.08.13.553136