eLife

Latest preprint reviews

1. Loss of Ptpmt1 limits mitochondrial utilization of carbohydrates and leads to muscle atrophy and heart failure in tissue-specific knockout mice

   This article has 14 authors:

   1. Hong Zheng
   2. Qianjin Li
   3. Shanhu Li
   4. Zhiguo Li
   5. Marco Brotto
   6. Daiana Weiss
   7. Domenick Prosdocimo
   8. Chunhui Xu
   9. Ashruth Reddy
   10. Michelle Puchowicz
   11. Xinyang Zhao
   12. M Neale Weitzmann
   13. Mukesh K Jain
   14. Cheng-Kui Qu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper provides a useful set of data examining the role of PTPMT1, a mitochondria-based phosphatase, in mitochondrial fuel selection. The data were collected and analyzed using solid methodology and can be used as a starting point for further studies that build on the findings here.

   Reviewed by eLife

2. A versatile high-throughput assay based on 3D ring-shaped cardiac tissues generated from human induced pluripotent stem cell-derived cardiomyocytes

   This article has 11 authors:

   1. Magali Seguret
   2. Patricia Davidson
   3. Stijn Robben
   4. Charlène Jouve
   5. Celine Pereira
   6. Quitterie Lelong
   7. Lucille Deshayes
   8. Cyril Cerveau
   9. Maël Le Berre
   10. Rita S Rodrigues Ribeiro
   11. Jean-Sébastien Hulot

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper reports a valuable platform for cardiac tissue cultivation. The throughput, consistency of the tissue, and the potential integration of high-throughput automation are an advantage over other approaches. The tissues and the platform are validated using appropriate methodology to provide convincing evidence of the tissue cultivation capability.

   Reviewed by eLife

3. The natural tannins oligomeric proanthocyanidins and punicalagin are potent inhibitors of infection by SARS-CoV-2

   This article has 12 authors:

   1. Hsiao-Fan Chen
   2. Wei-Jan Wang
   3. Chung-Yu Chen
   4. Wei-Chao Chang
   5. Po-Ren Hsueh
   6. Shin-Lei Peng
   7. Chen-Shiou Wu
   8. Yeh Chen
   9. Hsin-Yu Huang
   10. Wan-Jou Shen
   11. Shao-Chun Wang
   12. Mien-Chie Hung

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental work provides preclinical evidence to support that natural tannins derived from grapeseed can inhibit or prevent infection by the SARS-CoV-2 viruses. The evidence provided is mostly solid to convincing and supports the conclusions. This work will be of broad interest to cell biologists and physicians.

   Reviewed by eLife

4. SNORD90 induces glutamatergic signaling following treatment with monoaminergic antidepressants

   This article has 28 authors:

   1. Rixing Lin
   2. Aron Kos
   3. Juan Pablo Lopez
   4. Julien Dine
   5. Laura M Fiori
   6. Jennie Yang
   7. Yair Ben-Efraim
   8. Zahia Aouabed
   9. Pascal Ibrahim
   10. Haruka Mitsuhashi
   11. Tak Pan Wong
   12. El Cherif Ibrahim
   13. Catherine Belzung
   14. Pierre Blier
   15. Faranak Farzan
   16. Benicio N Frey
   17. Raymond W Lam
   18. Roumen Milev
   19. Daniel J Muller
   20. Sagar V Parikh
   21. Claudio Soares
   22. Rudolf Uher
   23. Corina Nagy
   24. Naguib Mechawar
   25. Jane A Foster
   26. Sidney H Kennedy
   27. Alon Chen
   28. Gustavo Turecki

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important study that uncovers a new molecular pathway that links traditional monoaminergic antidepressants with regulation of glutamate neurotransmission. The data provided for the model are convincing and demonstrate the pathway in human plasma and brain, mouse brain, and cultured cells, using the relative strengths of each system. The work will be of interest to psychiatrists studying depression as well as basic neurobiologists interested in monoamine signaling in the brain.

   Reviewed by eLife

5. Coronary artery established through amniote evolution

   This article has 12 authors:

   1. Kaoru Mizukami
   2. Hiroki Higashiyama
   3. Yuichiro Arima
   4. Koji Ando
   5. Norihiro Okada
   6. Katsumi Kose
   7. Shigehito Yamada
   8. Jun K Takeuchi
   9. Kazuko Koshiba-Takeuchi
   10. Shigetomo Fukuhara
   11. Sachiko Miyagawa-Tomita
   12. Hiroki Kurihara

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Mizukami et al. propose a scenario for the evolutionary origin of the coronary artery in amniotes by comparing the morphologies of the vasculatures across several species and developmental timepoints. They show that the coronary arteries of non-amniotes most closely resemble embryonic amniote aortic subepicardial vessels (ASVs), which are replaced by the true coronary arteries during amniote development. While the identification of common vascular structures in diverse taxa is a valuable contribution, additional developmental evidence is needed to confirm that such vessels are truly homologous.

   Reviewed by eLife

6. Spatial structure favors microbial coexistence except when slower mediator diffusion weakens interactions

   This article has 4 authors:

   1. Alexander Lobanov
   2. Samantha Dyckman
   3. Helen Kurkjian
   4. Babak Momeni

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study uses computational simulations to explore how spatial structure can affect the coexistence between different microbial species, ultimately helping to explain diversity in microbial communities. The evidence supporting the conclusions is solid, although the parameter values used in the simulations were deemed to be unrealistic. Further investigation on whether the conclusions would hold under more realistic assumptions would be very interesting to microbial ecologists quite broadly.

   Reviewed by eLife

7. Complex subsets but redundant clonality after B cells egress from spontaneous germinal centers

   This article has 7 authors:

   1. Carlos Castrillon
   2. Lea Simoni
   3. Theo van den Broek
   4. Cees van der Poel
   5. Elliot H Akama-Garren
   6. Minghe Ma
   7. Michael C Carroll

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Understanding the heterogeneity of the B cell response induced in autoimmune individuals is important for the development of therapies designed to target the cells underlying disease progression. Here the authors use a new mouse model of autoimmunity to assess the heterogeneity of the B cell response using single-cell RNA-sequencing and BCR-sequencing and found that these B cell responses are similar to those by exogenous protein immunization.

   Reviewed by eLife

8. Neuronal glutamate transporters control reciprocal inhibition and gain modulation in D1 medium spiny neurons

   This article has 9 authors:

   1. Maurice A Petroccione
   2. Lianna Y D'Brant
   3. Nurat Affinnih
   4. Patrick H Wehrle
   5. Gabrielle C Todd
   6. Shergil Zahid
   7. Haley E Chesbro
   8. Ian L Tschang
   9. Annalisa Scimemi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript reports important findings that help to understand the function of glutamate transporters and their effects on synaptic function at D1- and D2-MSNs within the dorsolateral striatum. These findings were evaluated to be of interest and well-executed. Overall, the majority of claims are supported by high quality data, but the evidence for some underlying mechanisms and region specificity were incomplete in the manuscript's current form.

   Reviewed by eLife

9. Competing neural representations of choice shape evidence accumulation in humans

   This article has 6 authors:

   1. Krista Bond
   2. Javier Rasero
   3. Raghav Madan
   4. Jyotika Bahuguna
   5. Jonathan Rubin
   6. Timothy Verstynen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study assesses how change in reward contingency in the environment affects the dynamics of a realistic large-scale neural circuit model, human choice behavior, and fMRI responses measured in the same individuals. It is not entirely clear which predictions of the neural circuit model go beyond previous work, the current results seem incomplete and could likely be substantially strengthened. This study could be of interest to scientists studying the neural and computational bases of adaptive behaviour.

   Reviewed by eLife

10. State-dependent coupling of hippocampal oscillations

    This article has 6 authors:

    1. Brijesh Modi
    2. Matteo Guardamagna
    3. Federico Stella
    4. Marilena Griguoli
    5. Enrico Cherubini
    6. Francesco P Battaglia

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      Traditional approaches for the analysis of brain rhythms typically rely on measuring spectro-temporal properties of individual oscillations or the interactions between two different oscillations. This manuscript presents a novel multivariate approach that uses a state space model to simultaneously analyze the dynamics and interactions of multiple hippocampal oscillations. Such an approach represents a step forward in the field that highlights the need of taking into account the complexity of network interactions rather than trying to understand each component of the system in isolation.

    Reviewed by eLife