eLife

Latest preprint reviews

1. Long-term hematopoietic transfer of the anti-cancer and lifespan-extending capabilities of a genetically engineered blood system by transplantation of bone marrow mononuclear cells

   This article has 17 authors:

   1. Jing-Ping Wang
   2. Chun-Hao Hung
   3. Yae-Huei Liou
   4. Ching-Chen Liu
   5. Kun-Hai Yeh
   6. Keh-Yang Wang
   7. Zheng-Sheng Lai
   8. Biswanath Chatterjee
   9. Tzu-Chi Hsu
   10. Tung-Liang Lee
   11. Yu-Chiau Shyu
   12. Pei-Wen Hsiao
   13. Liuh-Yow Chen
   14. Trees-Juen Chuang
   15. Chen-Hsin Albert Yu
   16. Nan-Shih Liao
   17. C-K James Shen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This useful manuscript focuses on understanding how an Eklf mutation confers anticancer and longevity advantages in vivo. The data demonstrate that Eklf (K74R) imparts such advantages in a background and age independent manner in both female and male mice, and that the benefits are transferable by bone marrow transplantation. Despite added data since a previous version, the paper unfortunately remains incomplete, as it is still unclear whether Eklf affects resistance to malignant progression/metastasis by modulating Pd1 or Pdl1, or by increasing NK cells. The authors provide evidence that supports in principle both mechanisms, and they do not resolve which mechanism is primarily involved.

   Reviewed by eLife

2. A large-scale proteomics resource of circulating extracellular vesicles for biomarker discovery in pancreatic cancer

   This article has 19 authors:

   1. Bruno Bockorny
   2. Lakshmi Muthuswamy
   3. Ling Huang
   4. Marco Hadisurya
   5. Christine Maria Lim
   6. Leo L Tsai
   7. Ritu R Gill
   8. Jesse L Wei
   9. Andrea J Bullock
   10. Joseph E Grossman
   11. Robert J Besaw
   12. Supraja Narasimhan
   13. Weiguo Andy Tao
   14. Sofia Perea
   15. Mandeep S Sawhney
   16. Steven D Freedman
   17. Manuel Hildago
   18. Anton Iliuk
   19. Senthil K Muthuswamy

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors analyze a comprehensive cohort of human plasma samples to identify an extracellular vesicles protein signature for early diagnosis of pancreatic cancer. The application of liquid biopsies is valuable, and the work addresses a key clinical problem as pancreas cancer is often diagnosed in late stages. The strength of evidence is solid. Altogether, this work supports the potential use of extracellular vesicles in clinical settings, with promising value to scientists and clinicians.

   Reviewed by eLife

3. PITAR, a DNA damage-inducible cancer/testis long noncoding RNA, inactivates p53 by binding and stabilizing TRIM28 mRNA

   This article has 11 authors:

   1. Samarjit Jana
   2. Mainak Mondal
   3. Sagar Mahale
   4. Bhavana Gupta
   5. Kaval Reddy Prasasvi
   6. Lekha Kandasami
   7. Neha Jha
   8. Abhishek Chowdhury
   9. Vani Santosh
   10. Chandrasekhar Kanduri
   11. Kumaravel Somasundaram

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study reports, with convincing evidence, that a long non-coding RNA disrupts the activity of the tumor suppressor p53 to contribute to the growth and therapeutic response of glioblastoma. The work will be relevant to scientists working on non-coding RNAs and brain tumors.

   Reviewed by eLife

4. The integration of Tgfβ and Egfr signaling programs confers the ability to lead heterogeneous collective invasion

   This article has 9 authors:

   1. Apsra Nasir
   2. Sharon Camacho
   3. Alec T. McIntosh
   4. Garrett T. Graham
   5. Raneen Rahhal
   6. Molly E. Huysman
   7. Fahda Alsharief
   8. Anna T. Riegel
   9. Gray W. Pearson

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This represents an important study that demonstrates a high degree of heterogeneity within trailblazer cells in clusters that participate in collective migration. Solid methods highlight this heterogeneity and show that in TNBC cancers, trailblazer cells are defined by vimentin (and not Keratin 14) and are dependent on both TGFbeta and EGFR signaling.

   Reviewed by eLife

5. CryoEM structures of Kv1.2 potassium channels, conducting and non-conducting

   This article has 7 authors:

   1. Yangyu Wu
   2. Yangyang Yan
   3. Youshan Yang
   4. Shumin Bian
   5. Alberto Rivetta
   6. Ken Allen
   7. Fred J Sigworth

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important manuscript presents several structures of the Kv1.2 voltage-gated potassium channel, based on state-of-the-art cryoEM techniques and algorithms. The authors present solid evidence for structures of an inactivating mutant of Kv1.2, DTX-bound Kv1.2 and of Kv1.2 in potassium-free solution (with presumably sodium ions bound within the selectivity filter). These structures advance our knowledge of the molecular basis of the slow inactivation process of potassium channels.

   Reviewed by eLife

6. Identification of 1600 replication origins in S. cerevisiae

   This article has 7 authors:

   1. Eric J Foss
   2. Carmina Lichauco
   3. Tonibelle Gatbonton-Schwager
   4. Sara J Gonske
   5. Brandon Lofts
   6. Uyen Lao
   7. Antonio Bedalov

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study represents a valuable addition to the understanding of the DNA replication origin selection process in the budding yeast. The authors provide convincing evidence that the number of possible origins of replication is much higher than previously appreciated, although many of the newly identified origins are likely to only direct replication initiation rarely. This work will be of interest to those studying DNA replication and investigating protein-DNA interactions across the genome.

   Reviewed by eLife

7. Imputation of 3D genome structure by genetic–epigenetic interaction modeling in mice

   This article has 8 authors:

   1. Lauren Kuffler
   2. Daniel A Skelly
   3. Anne Czechanski
   4. Haley J Fortin
   5. Steven C Munger
   6. Christopher L Baker
   7. Laura G Reinholdt
   8. Gregory W Carter

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important manuscript reports interactions between genetic variation, DNA accessibility, and chromatin structure in gene expression at a genome wide scale. The authors found that most of these interactions occur within topologically associating domains (TADs) and 3D genome structure data can be efficiently used to guide the discovery of significant genetic and epigenetic influences on gene expression. Overall, this convincing study highlights the importance of 3D chromatin structure in controlling how gene expression is regulated by genetic and epigenetic processes.

   Reviewed by eLife

8. BATF relieves hepatic steatosis by inhibiting PD1 and promoting energy metabolism

   This article has 12 authors:

   1. Zhiwang Zhang
   2. Qichao Liao
   3. Tingli Pan
   4. Lin Yu
   5. Zupeng Luo
   6. Songtao Su
   7. Shi Liu
   8. Menglong Hou
   9. Yixing Li
   10. Turtushikh Damba
   11. Yunxiao Liang
   12. Lei Zhou

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study presents reports on the role of the transcription factor BATF and its target PD1 in lipid metabolism including a model of nonalcoholic fatty liver disease (NAFLD). Overall, the evidence supporting the conclusions is convincing. The work will be of interest to medical biologists working on NAFLD.

   Reviewed by eLife

9. Delta-dependent Notch activation closes the early neuroblast temporal program to promote lineage progression and neurogenesis termination in Drosophila

   This article has 6 authors:

   1. Chhavi Sood
   2. Md Ausrafuggaman Nahid
   3. Kendall R Branham
   4. Matt Pahl
   5. Susan E Doyle
   6. Sarah E Siegrist

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This useful study reports on how Notch activity regulates the termination of neurogenesis in central brain during larval-pupal stages in Drosophila. The evidence supporting the claims is solid. The work will be of interest to developmental neurobiologists.

   Reviewed by eLife

10. Repeatability of adaptation in sunflowers reveals that genomic regions harbouring inversions also drive adaptation in species lacking an inversion

    This article has 7 authors:

    1. Shaghayegh Soudi
    2. Mojtaba Jahani
    3. Marco Todesco
    4. Gregory L Owens
    5. Natalia Bercovich
    6. Loren H Rieseberg
    7. Sam Yeaman

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This is a valuable comparative study of local adaptation using gene-by-environment and gene-by-phenotype correlations. The analyses seemed still incomplete, as the biological take-home messages were obscured by the statistical approaches used, and it remains unclear how to best interpret the level of genome-wide convergence and in inversions. The repeatability of local adaptation across species, and the role of inversions in local adaptation, are questions of considerable empirical interest.

    Reviewed by eLife