eLife reviews preprints in the life sciences and medicine.

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  1. Differential regulation of hair cell actin cytoskeleton mediated by SRF and MRTFB

    1. Ling-Yun Zhou
    2. Chen-Xi Jin
    3. Wen-Xiao Wang
    4. Lei Song
    5. Jung-Bum Shin
    6. Ting-Ting Du
    7. Hao Wu

    • Curated by eLife

      eLife assessment

      This valuable study provides solid evidence implicating two transcription factors in the development of the actin cytoskeleton that shapes the mechanosensory hair bundles of the inner ear's hair cells. The work will be of interest to biologists interested in the development and maintenance of the hair bundle, both normal or impaired. Its impact would be improved by providing a mechanistic model for the observed effects.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  3. Regulation of pDC fate determination by histone deacetylase 3

    1. Yijun Zhang
    2. Tao Wu
    3. Zhimin He
    4. Wenlong Lai
    5. Xiangyi Shen
    6. Jiaoyan Lv
    7. Yuanhao Wang
    8. Li Wu

    • Curated by eLife

      eLife assessment

      This study examines the expression of HDAC3 within DC compartment. Taking advantage of tamoxifen inducible ERT2-cre mouse model they observe the dependency of pDCs but not cDCs on HDAC3. The requirement of this histone modifier appears to occur during development around the CLP stage. Tamoxifen treated mice lack almost all pDC besides lymphoid progenitors. RNA seq studies identify multiple DC specific target genes within the remaining pDC - using Cut and Tag technology they validate some of the identified targets of HDAC3. Taken together, this study shows the requirement of HDAC3 on pDC but not cDC, congruent with the recent findings of a lymphoid origin of pDC.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  4. Modulation of input sensitivity and output gain by retinal amacrine cells

    1. Neda Nategh
    2. Mihai Manu
    3. Stephen A. Baccus

    • Curated by eLife

      eLife assessment

      This paper studies how amacrine cells influence retinal output signals. The approach taken is unusually direct and has the potential to make important contributions to our understanding of amacrine cells, and more generally interneurons, to circuit function. The contributions of the work described, however, are limited by several key concerns. Specifically, the results rely heavily on assumptions made about how signals traverse the retina; as a result, the evidence for adequate separation of signals contributed by the amacrine cells and those from other parallel retinal pathways is incomplete.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity

  8. Pinpoint: trajectory planning for multi-probe electrophysiology and injections in an interactive web-based 3D environment

    1. Daniel Birman
    2. Kenneth J. Yang
    3. Steven J. West
    4. Bill Karsh
    5. Yoni Browning
    6. the International Brain Laboratory
    7. Joshua H. Siegle
    8. Nicholas A. Steinmetz

    • Curated by eLife

      eLife assessment

      Birman et al. present a valuable software interface, Pinpoint, for planning anatomically precise insertions of rigid instruments (e.g., electrodes, injection needles/pipettes, fibre optic implants) into the mouse brain. The authors provide compelling evidence of the potential of this software since, it: (1) incorporates the geometrical constraints of the rig and instruments; (2) interfaces with popular manipulator systems and data acquisition software; (3) runs on any browser; and (4) allows for easy collaboration among users. Despite these exciting features, quantification of the gains in experimental efficiency and accuracy derived from Pinpoint is needed.

    Reviewed by eLife

    4 evaluationsAppears in 1 listLatest version Latest activity
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