eLife

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1. We couldn't get details of this article at this time:
   10.1101/2023.09.05.556211

2. We couldn't get details of this article at this time:
   10.1101/2023.06.28.546927

3. We couldn't get details of this article at this time:
   10.1101/2021.12.24.474127

4. Dynamic analysis of circulating tumor DNA to predict the prognosis and monitor the treatment response of patients with metastatic triple-negative breast cancer: A prospective study

   This article has 14 authors:

   1. Yajing Chi
   2. Mu Su
   3. Dongdong Zhou
   4. Fangchao Zheng
   5. Baoxuan Zhang
   6. Ling Qiang
   7. Guohua Ren
   8. Lihua Song
   9. Bing Bu
   10. Shu Fang
   11. Bo Yu
   12. Jinxing Zhou
   13. Jinming Yu
   14. Huihui Li

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This prospective study advances our understanding of the predictive role of circulating tumor DNA (ctDNA) in the prognosis and of patients with mTNBC as well as other cancers. The evidence supporting the conclusions is convincing with rigorous analysis of the association between ctDNA (ctDNA-positive or not) with the progression-free survival (PFS) of patients. However, there are a few areas in which the article may be improved through further analysis of the clinical outcome and elaboration of the prospective study (i.e., the inclusion and exclusion criteria of the patients). The work will be of broad interest to clinicians, medical researchers and scientists working in cancers.

   Reviewed by eLife

5. Multiple NTS neuron populations cumulatively suppress food intake

   This article has 7 authors:

   1. Weiwei Qiu
   2. Chelsea R Hutch
   3. Yi Wang
   4. Jennifer Wloszek
   5. Rachel A Rucker
   6. Martin G Myers
   7. Darleen Sandoval

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment:

     Interoceptive signals from internal organs activate neurons in the nucleus tractus solitarius (NTS) to help maintain homeostasis. The authors of this paper use gain-of-function and loss-of-function experiments to examine three distinct NTS neuronal populations, individually and in combination, and find that activating (or inhibiting) combinations of these neurons have more robust effects on food intake and body weight than activating (or inhibiting) them individually. The results of this paper are convincing and solid but do not provide mechanistic insights.

   Reviewed by eLife

6. Melanopsin activates divergent phototransduction pathways in intrinsically photosensitive retinal ganglion cell subtypes

   This article has 5 authors:

   1. Ely Contreras
   2. Jacob D Bhoi
   3. Takuma Sonoda
   4. Lutz Birnbaumer
   5. Tiffany M Schmidt

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Retinal ganglion cells which are intrinsically photosensitive play important and emerging physiological roles. The mechanisms of phototransduction are still not well known and there exists a controversy regarding the ion channels responsible for the photocurrent. The authors of this manuscript present data that can contribute to understanding the actual ionic mechanisms in two of these cell types. This manuscript will be of general interest to biologists and neuroscientists and should help resolve a major issue in retinal physiology.

   Reviewed by eLife

7. We couldn't get details of this article at this time:
   10.1101/2022.02.23.481592

8. Effects of neoadjuvant stereotactic body radiotherapy plus adebrelimab and chemotherapy for triple-negative breast cancer: A pilot study

   This article has 23 authors:

   1. Guanglei Chen
   2. Xi Gu
   3. Jinqi Xue
   4. Xu Zhang
   5. Xiaopeng Yu
   6. Yu Zhang
   7. Ailin Li
   8. Yi Zhao
   9. Guijin He
   10. Meiyue Tang
   11. Fei Xing
   12. Jianqiao Yin
   13. Xiaobo Bian
   14. Ye Han
   15. Shuo Cao
   16. Chao Liu
   17. Xiaofan Jiang
   18. Keliang Zhang
   19. Yan Xia
   20. Huajun Li
   21. Nan Niu
   22. Caigang Liu
   23. On behalf of the Northeastern Clinical Research Alliance of Oncology (NCRAO)

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a valuable finding of a novel combinatory regimen which integrate immunotherapy, radiotherapy and chemotherapy in the current refractory triple negative breast cancer. The evidence supporting the claims of the authors is solid, although inclusion of a larger number of patient samples would have strengthened the study. The work will be of interest to Clinicians working on breast cancer.

   Reviewed by eLife

9. We couldn't get details of this article at this time:
   10.1101/2023.01.04.521570

10. Multiple cullin-associated E3 ligases regulate cyclin D1 protein stability

    This article has 6 authors:

    1. Ke Lu
    2. Ming Zhang
    3. Guizheng Wei
    4. Guozhi Xiao
    5. Liping Tong
    6. Di Chen

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This paper is of interest to cell biologists studying the mechanisms of protein posttranslational modifications. The study investigates Cullin-RING ubiquitin E3 ligases (CRLs) that regulate cyclin D1 protein stability in cells by utilizing siRNA screening and ectopic expression approaches. By screening a siRNA library containing different E3 ligases, the authors identified a previously uncharacterized combination of Cullin 1-7 and associated E3 ligases (Keap1-CUL3, DDB2-CUL4A/4B, WSB2-CUL2/5, and RBX1-CUL1-7) that are important for cyclin D1 ubiquitination and proteasome-mediated degradation.

    Reviewed by eLife