Latest preprint reviews

  1. Quantitative Geometric Modeling of Blood Cells from X-ray Histotomograms of Whole Zebrafish Larvae

    This article has 12 authors:
    1. Maksim A. Yakovlev
    2. Ke Liang
    3. Carolyn R. Zaino
    4. Daniel J. Vanselow
    5. Andrew L. Sugarman
    6. Alex Y. Lin
    7. Patrick J. La Riviere
    8. Yuxi Zheng
    9. Justin D. Silverman
    10. John C. Leichty
    11. Sharon X. Huang
    12. Keith C. Cheng
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      Tissue phenotyping is central to nearly all areas of biology. In this study, the authors use an advanced form of micro-CT (X-ray histotomography) in zebrafish to phenotype blood cells in the intact animal. These approaches build upon prior work from this group and others showing this is a scalable imaging method that could readily be applied to other cell types, and provide an excellent complement to histological analysis of tissues. This is important work, as it demonstrates that the method can provide an approach that is orthogonal to conventional histology. The strength of the presented data is compelling, with description of both the hardware and software needed to implement the protocol, which will make it accessible to other researchers in the field.

    Reviewed by eLife

    This article has 2 evaluationsAppears in 1 listLatest version Latest activity
  2. Shh from mossy cells contributes to preventing NSC pool depletion after seizure-induced neurogenesis and in aging

    This article has 5 authors:
    1. Hirofumi Noguchi
    2. Jessica Chelsea Arela
    3. Thomas Ngo
    4. Laura Cocas
    5. Samuel Pleasure
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study uses specific and robust genetic approaches to assess mechanisms of kainic acid-induced neurogenesis. This is a fundamental study that bridges several complementary methods and is a convincing use of existing approaches to explore roles for sonic hedgehog in activity-dependent and aging-associated hippocampal neurogenesis.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  3. Resistance exercise protects mice from protein-induced fat accretion

    This article has 11 authors:
    1. Michaela E Trautman
    2. Leah N Braucher
    3. Christian Elliehausen
    4. Wenyuan G Zhu
    5. Esther Zelenovskiy
    6. Madelyn Green
    7. Michelle M Sonsalla
    8. Chung-Yang Yeh
    9. Troy A Hornberger
    10. Adam R Konopka
    11. Dudley W Lamming
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents a valuable finding on relationship between high protein diet and resistance exercise on fat accumulation and glucose homeostasis. The evidence supporting the claims of the authors is solid, although inclusion of mechanistic insight would have strengthened the study. The work will be of interest to dietician and exercise biologists working to understand the synergy between diet and physical activity.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
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