eLife

Latest preprint reviews

1. Inhibition of microtubule detyrosination by parthenolide facilitates functional CNS axon regeneration

   This article has 8 authors:

   1. Marco Leibinger
   2. Charlotte Zeitler
   3. Miriam Paulat
   4. Philipp Gobrecht
   5. Alexander Hilla
   6. Anastasia Andreadaki
   7. Rainer Guthoff
   8. Dietmar Fischer

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The primary goal of this paper is to examine microtubule detyrosination as a potential therapeutic target for axon regeneration. The valuable findings of this study provide convincing evidence for mechanistic links between microtubule detyrosination and neurite outgrowth in vitro and some evidence for axon regeneration in vivo.

   Reviewed by eLife

2. De novo identification of universal cell mechanics gene signatures

   This article has 17 authors:

   1. Marta Urbanska
   2. Yan Ge
   3. Maria Winzi
   4. Shada Abuhattum
   5. Syed Shafat Ali
   6. Maik Herbig
   7. Martin Kräter
   8. Nicole Toepfner
   9. Joanne Durgan
   10. Oliver Florey
   11. Martina Dori
   12. Federico Calegari
   13. Fidel-Nicolás Lolo
   14. Miguel Ángel del Pozo
   15. Anna Taubenberger
   16. Carlo Vittorio Cannistraci
   17. Jochen Guck

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study uses machine learning-based network analysis on transcriptomic data from different tissue cell types to identify a small set of conserved (pan-tissue) genes associated with changes in cell mechanics. The new method, which provides a new type of approach for mechanobiology, is accessible, compelling, and well-validated using in silico and experimental approaches. The study provides motivation for researchers to test hypotheses concerning the identified five-gene network, and the method will be strengthened over time with expanded sets of validations, such as testing genes with hitherto unknown roles and different perturbation techniques.

   Reviewed by eLife

3. A statistical framework for quantifying the nuclear export rate of influenza viral mRNAs

   This article has 8 authors:

   1. Michi Miura
   2. Naho Kiuchi
   3. Siu-Ying Lau
   4. Bobo Wing-Yee Mok
   5. Hiroshi Ushirogawa
   6. Tadasuke Naito
   7. Honglin Chen
   8. Mineki Saito

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study combines virology experiments and mathematical modeling to determine the nuclear export rate of each of the eight RNA segments of the influenza A virus, leading to the proposal that a specific retention of mRNA within the nucleus delays the expression of antigenic viral proteins. The proposed model for explaining the differential rate of export is compelling, going beyond the state of the art, but the experimental setup is only in partial support and further studies will be needed to confirm the proposed mechanism.

   Reviewed by eLife

4. Sustained store-operated calcium entry utilizing activated chromatin state leads to instability in iTregs

   This article has 10 authors:

   1. Huiyun Lyu
   2. Guohua Yuan
   3. Xinyi Liu
   4. Xiaobo Wang
   5. Shuang Geng
   6. Tie Xia
   7. Xuyu Zhou
   8. Yinqing Li
   9. Xiaoyu Hu
   10. Yan Shi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents the valuable finding that sustained calcium signaling in induced-Treg (iTreg) cells can lead to the loss of Foxp3 expression and iTreg identity by altering the chromatin landscape. The evidence supporting the claims of the authors is convincing. The work will be of interest to immunologists working on Treg cell therapy.

   Reviewed by eLife

5. Mitochondrial temperature homeostasis resists external metabolic stresses

   This article has 10 authors:

   1. Mügen Terzioglu
   2. Kristo Veeroja
   3. Toni Montonen
   4. Teemu O Ihalainen
   5. Tiina S Salminen
   6. Paule Bénit
   7. Pierre Rustin
   8. Young-Tae Chang
   9. Takeharu Nagai
   10. Howard T Jacobs

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The study provides useful data supporting prior findings that mitochondria in cultured cells maintain a temperature that is up to 15°C above the external temperature at which cultured cells are maintained. The evidence supporting the hypothesis is solid, although direct measures of temperature in isolated mitochondria or comparison with other cellular compartments would have strengthened the ability to interpret the relevance of the findings. Nevertheless, the bioenergetic implications of the work will be of interest to cell biologists, biochemists, and physiologists.

   Reviewed by eLife

6. Gaze patterns and brain activations in humans and marmosets in the Frith-Happé theory-of-mind animation task

   This article has 5 authors:

   1. Audrey Dureux
   2. Alessandro Zanini
   3. Janahan Selvanayagam
   4. Ravi S Menon
   5. Stefan Everling

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides useful findings regarding the capacity for mental state attribution on the Frith-Happé task in a highly social non-human primate species, the marmoset. The methods are solid, integrating validated brain imaging and eye-tracking techniques, however, the theoretical analysis is incomplete due to the omission of a "goal-directed condition." The inclusion of the goal-directed condition would enable a stronger interpretation of the findings and would be of broad interest to neuroscientists working in social and affective sciences.

   Reviewed by eLife

7. Neural circuit mechanisms for transforming learned olfactory valences into wind-oriented movement

   This article has 8 authors:

   1. Yoshinori Aso
   2. Daichi Yamada
   3. Daniel Bushey
   4. Karen L Hibbard
   5. Megan Sammons
   6. Hideo Otsuna
   7. Yichun Shuai
   8. Toshihide Hige

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides important new insights into how learning affects behavior in the Drosophila model. Using a combination of connectomics, neurophysiology, and behavioral analysis, a small group of neurons in the Drosophila brain that integrates learned odor valences and promotes odor tracking by driving upwind orientation and movement is described. The study's conclusion is supported by convincing evidence and rigorous quantitative analysis. Insights from the neural circuit mechanism that translates learning-induced plasticity into appropriate behavioral actions will be of broad interest to neuroscientists.

   Reviewed by eLife

8. Towards biologically plausible phosphene simulation for the differentiable optimization of visual cortical prostheses

   This article has 10 authors:

   1. Maureen van der Grinten
   2. Jaap de Ruyter van Steveninck
   3. Antonio Lozano
   4. Laura Pijnacker
   5. Bodo Rueckauer
   6. Pieter Roelfsema
   7. Marcel van Gerven
   8. Richard van Wezel
   9. Umut Güçlü
   10. Yağmur Güçlütürk

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This simulation work with open source code will be of interest to those developing visual prostheses and demonstrates useful improvements over past visual prosthesis simulations. While the authors provide compelling evidence to support the generation of individual phosphenes and integration into deep-learning algorithms, the assumptions beyond individual phosphenes and the overall validation process are inadequate to support the claim of fitting the needs of cortical neuroprosthetic vision development.

   Reviewed by eLife

9. Healthcare in England was affected by the COVID-19 pandemic across the pancreatic cancer pathway: A cohort study using OpenSAFELY-TPP

   This article has 14 authors:

   1. Agnieszka Lemanska
   2. Colm Andrews
   3. Louis Fisher
   4. Seb Bacon
   5. Adam E Frampton
   6. Amir Mehrkar
   7. Peter Inglesby
   8. Simon Davy
   9. Keith Roberts
   10. Praveetha Patalay
   11. Ben Goldacre
   12. Brian MacKenna
   13. The OpenSAFELY Collaborative
   14. Alex J Walker

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides useful information on the impact of the pandemic on the quantity of healthcare delivered to patients with pancreatic cancer in England. The authors showed that there was no difference in the number of diagnoses of pancreatic cancer during the pandemic compared to the preceding 5-year period, but a reduction in surgical resections by nearly 25%. They reported no difference in deaths between the two periods. They show no differences in rates of diagnosis, but the clinical relevance is incomplete as they have not compared survival from cancer between those time periods.

   Reviewed by eLife

10. Epigenetic signature of human immune aging in the GESTALT study

    This article has 26 authors:

    1. Roshni Roy
    2. Pei-Lun Kuo
    3. Julián Candia
    4. Dimitra Sarantopoulou
    5. Ceereena Ubaida-Mohien
    6. Dena Hernandez
    7. Mary Kaileh
    8. Sampath Arepalli
    9. Amit Singh
    10. Arsun Bektas
    11. Jaekwan Kim
    12. Ann Z Moore
    13. Toshiko Tanaka
    14. Julia McKelvey
    15. Linda Zukley
    16. Cuong Nguyen
    17. Tonya Wallace
    18. Christopher Dunn
    19. William Wood
    20. Yulan Piao
    21. Christopher Coletta
    22. Supriyo De
    23. Jyoti Sen
    24. Nan-ping Weng
    25. Ranjan Sen
    26. Luigi Ferrucci

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This is an important study reanalysing previously published datasets to understand methylation changes during aging. The evidence supporting the conclusions is solid and sheds new light on features of aging in cells, highlighting the concept of cell-specific methylation changes and their relationship to other physiological changes such as inflammation that may impact methylation patterns. This work will be of broad interest to cell and molecular biologists.

    Reviewed by eLife