eLife

Latest preprint reviews

1. Primaquine in glucose-6-phosphate dehydrogenase deficiency: an adaptive pharmacometric assessment of ascending dose regimens in healthy volunteers

   This article has 13 authors:

   1. Sasithon Pukrittayakamee
   2. Podjanee Jittamala
   3. James A Watson
   4. Borimas Hanboonkunupakarn
   5. Pawanrat Leungsinsiri
   6. Kittiyod Poovorawan
   7. Kesinee Chotivanich
   8. Germana Bancone
   9. Cindy S Chu
   10. Mallika Imwong
   11. Nicholas PJ Day
   12. Walter RJ Taylor
   13. Nicholas J White

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript addresses an important question, that in countries endemic for P vivax the need to administer a primaquine (PQ) course adequate to prevent relapse in G6PD deficient persons poses a real dilemma. On one hand PQ will cause haemolysis; on the other hand, without PQ the chance of relapse is very high. As a result, out of fear of severe haemolysis, PQ has been under-used. This manuscript is convincing that regimen (1) can be used successfully to deliver within 3 weeks, under hospital conditions, the dose of PQ required to prevent P vivax relapse.

   Reviewed by eLife

2. Discovery and characterization of cross-reactive intrahepatic antibodies in severe alcoholic hepatitis

   This article has 24 authors:

   1. Ali Reza Ahmadi
   2. Guang Song
   3. Tianshun Gao
   4. Jing Ma
   5. Xiaomei Han
   6. Ming-Wen Hu
   7. Andrew M Cameron
   8. Russell N Wesson
   9. Benjamin Philosophe
   10. Shane Ottmann
   11. Elizabeth King
   12. Ahmet Gurakar
   13. Le Qi
   14. Brandon Peiffer
   15. James Burdick
   16. Robert Anders
   17. Zhanxiang Zhou
   18. Hongkun Lu
   19. Dechun Feng
   20. Chien-Sheng Chen
   21. Jiang Qian
   22. Bin Gao
   23. Heng Zhu
   24. Zhaoli Sun

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study tested the hypothesis that liver-derived but not serum-derived antibodies that are cross-reactive to E.coli and to host proteins can play a role in the hepatic damage found in severe alcoholic hepatitis (SAH). Using a solid methodology that includes state-of-the-art microscopy, proteome arrays, and gene ontology assays, it provides strong evidence that liver-derived IgG and IgA with cytotoxic properties and reactivity to both gut-derived E.coli and autoantigens accumulated in hepatocytes of SAH patients but not of healthy controls. The study would benefit from a broader analysis of gut microbiota proteome and further characterization of B cells infiltrating the liver tissue including their numbers/field and their origin (infiltrating versus resident cells). The work opens new avenues of understanding for the pathogenesis of severe alcoholic hepatitis and is of great interest to researchers and clinicians in the field.

   Reviewed by eLife

3. ARID1A governs the silencing of sex-linked transcription during male meiosis in the mouse

   This article has 4 authors:

   1. Debashish U Menon
   2. Prabuddha Chakraborty
   3. Noel Murcia
   4. Terry Magnuson

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a valuable dataset regarding chromatin remodeling by the BAF complex in the context of meiotic sex chromosome inactivation. Solid data generally support the conclusions, although the partial deletion of the BAF complex in the germline could be considered limiting. This work will be of interest to researchers working on chromatin and reproductive biology.

   Reviewed by eLife

4. FMRP regulates postnatal neuronal migration via MAP1B

   This article has 9 authors:

   1. Salima Messaoudi
   2. Ada Allam
   3. Julie Stoufflet
   4. Theo Paillard
   5. Anaïs Le Ven
   6. Coralie Fouquet
   7. Mohamed Doulazmi
   8. Alain Trembleau
   9. Isabelle Caille

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study addresses the role of FMRP in the migration of newborn neuroblasts in the postnatal brain. Through extensive and convincing analysis of living imaging videos, the authors showed that neurons with FMRP deletion migrate aberrantly and exhibit defects in nucleokinesis and centrokinesis. The study presents a valuable finding on the mechanism of neuroblast migration in the postnatal brain.

   Reviewed by eLife

5. Reward contingency gates selective cholinergic suppression of amygdala neurons

   This article has 15 authors:

   1. Eyal Y Kimchi
   2. Anthony Burgos-Robles
   3. Gillian A Matthews
   4. Tatenda Chakoma
   5. Makenzie Patarino
   6. Javier C Weddington
   7. Cody Siciliano
   8. Wannan Yang
   9. Shaun Foutch
   10. Renee Simons
   11. Ming-fai Fong
   12. Miao Jing
   13. Yulong Li
   14. Daniel B Polley
   15. Kay M Tye

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable manuscript examines the role of basal forebrain cholinergic (ACh) projection neurons and their inputs to the basolateral amygdala (BLA) and effects on BLA activity during reward seeking. The manuscript provides compelling evidence that ACh may have different effects on network activity in the BLA depending on the state of the network during reward engagement, whereas behavioural data indicating that these ACh neurons/inputs are involved in uncued reward seeking specifically is somewhat less complete. The paper will be of interest to those studying amygdala circuitry, reward processing, and neuromodulation broadly defined.

   Reviewed by eLife

6. Effort cost of harvest affects decisions and movement vigor of marmosets during foraging

   This article has 8 authors:

   1. Paul Hage
   2. In Kyu Jang
   3. Vivian Looi
   4. Mohammad Amin Fakharian
   5. Simon P Orozco
   6. Jay S Pi
   7. Ehsan Sedaghat-Nejad
   8. Reza Shadmehr

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study unravels the interaction between effort cost, pupil-indexed brain state, and movement (saccadic) vigor during foraging decisions in marmoset monkeys. Based on a normative computational model, the authors derive the prediction that anticipated effort should affect both decisions and movement vigor during foraging; and then provide solid behavioural and pupillometric evidence for this prediction in a foraging task. This paper will be of interest to decision and motor neuroscience as well as to all researchers studying animal behavior.

   Reviewed by eLife

7. Molecular tuning of sea anemone stinging

   This article has 8 authors:

   1. Lily S He
   2. Yujia Qi
   3. Corey AH Allard
   4. Wendy A Valencia-Montoya
   5. Stephanie P Krueger
   6. Keiko Weir
   7. Agnese Seminara
   8. Nicholas W Bellono

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important paper that links distinctive stinging behavior of two related anemones occupying different ecological niches to varying inactivation properties of voltage-gated calcium channels conferred by auxiliary Cavβ subunits. Further convincing evidence is provided that these differences are mediated by alternative splicing of Cavβ subunit of the calcium channel. The study will be of interest to scientists studying Ca2+ signaling, ion channel biophysicists, and marine biologists.

   Reviewed by eLife

8. DNA methylation-environment interactions in the human genome

   This article has 5 authors:

   1. Rachel A Johnston
   2. Katherine A Aracena
   3. Luis B Barreiro
   4. Amanda J Lea
   5. Jenny Tung

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important paper uses a genome-wide, massively parallel reporter assay to determine how CpG methylation affects regulatory sequences that control the expression of human genes. The authors provide compelling evidence that methylation not only influences baseline activity of regulatory sequences but also the magnitude of acute responses to environmental stimuli. The findings are of broad interest, and the extensive data set will likely become a key resource for the community.

   Reviewed by eLife

9. Dietary Restriction Impacts Peripheral Circadian Clock Output Important for Longevity in Drosophila

   This article has 11 authors:

   1. Dae-Sung Hwangbo
   2. Yong-Jae Kwon
   3. Marta Iwanaszko
   4. Peng Jiang
   5. Ladan Abbasi
   6. Nicholas Wright
   7. Sarayu Alli
   8. Alan L. Hutchison
   9. Aaron R. Dinner
   10. Rosemary I Braun
   11. Ravi Allada

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study describes important findings on how a core component of the circadian clock impacts the effect of dietary restriction (DR) on longevity and fecundity in Drosophila, which lead the authors to postulate rhythmic control of proteostasis in the fat body as a critical aspect of DR effects. The evidence presented is still incomplete, not fully supporting the conclusions of the study, as alternative hypotheses/explanations have not yet been systematically explored. The work will nevertheless be of substantial interest to researchers working in circadian and cell biology, metabolism, and aging, with an interesting hypothesis to be explored further.

   Reviewed by eLife

10. Free energy landscapes of KcsA inactivation

    This article has 2 authors:

    1. Sergio Pérez-Conesa
    2. Lucie Delemotte

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      In this valuable study, advanced simulation methodologies are used to extract the mechanisms of inactivation for the potassium ion channel KcsA. The string method approach provides solid evidence that reveal features associated with the interplay between gate size and collapse of the selectivity filter, as well as remarkable differences between different force fields. While this manuscript does not address recent discoveries in K channel inactivation involving dilated selectivity filter structures obtained by Xray and cryo-EM, it does help us understand the KcsA constriction process. With added descriptions and analysis of collective variables, improved reproducibility of results, consistency between string method free energies and unbiased simulations, and improved transition rate calculation, this manuscript will be of interest to the ion channel field.

    Reviewed by eLife