Latest preprint reviews

  1. H2-O deficiency promotes regulatory T cell differentiation and CD4 T cell hyperactivity

    This article has 5 authors:
    1. Robin A. Welsh
    2. Nianbin Song
    3. Chan-Su Park
    4. J. David Peske
    5. Scheherazade Sadegh-Nasseri
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This paper seeks to understand how the presentation of peptides by medullary thymic epithelial cells may be regulated by the MHCII peptide loading modulator, H2-O, and how this may affect the selection of regulatory T (Treg) cells. Further work is needed to ensure that the findings are robust: currently the analysis of data is inadequate and inconsistencies in the reported findings are not placed in context with results from other groups. The current version does not provide sufficient support for the claims regarding the effects on Treg cell selection.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. A Chemical Reaction Similarity-Based Prediction Algorithm Identifies the Multiple Taxa Required to Catalyze an Entire Metabolic Pathway of Dietary Flavonoids

    This article has 6 authors:
    1. Ebru Ece Gulsan
    2. Farrhin Nowshad
    3. Pomaikaimaikalani Yamaguchi
    4. Xiaokun Dong
    5. Arul Jayaraman
    6. Kyongbum Lee
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This paper reports useful findings regarding gut bacteria that metabolize dietary flavonoids, which can enhance, reduce, or otherwise alter the flavonoid bioactivities. With a newly developed bioinformatics tool, the authors predict bacterial species that can metabolize parts of the flavonoid tilianin. Formal proof of concept is missing, but if experimentally confirmed, the study will change the way we think about metabolism of flavonoids and would be of broad interest regarding gut bacterial metabolism. Most of the analyses are compelling, but others require further inquiry.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
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