eLife

Latest preprint reviews

1. Acute opioid responses are modulated by dynamic interactions of Oprm1 and Fgf12

   This article has 17 authors:

   1. Paige M Lemen
   2. Yanning Zuo
   3. Alexander S Hatoum
   4. Price E Dickson
   5. Guy Mittleman
   6. Arpana Agrawal
   7. Benjamin C Reiner
   8. Wade Berrettini
   9. David G Ashbrook
   10. Mustafa Hakan Gunturkun
   11. Xusheng Wang
   12. Megan K Mulligan
   13. Caleb J Browne
   14. Eric J Nestler
   15. Francesca Telese
   16. Robert W Williams
   17. Hao Chen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study integrates large-scale behavioral, genetic, and molecular analyses in animal models to investigate morphine response. Utilizing high-quality, time-series Quantitative Trait Loci (QTL) mapping, the work provides compelling evidential support for novel, time-dependent genetic interactions (epistasis). A fundamental result of this rigorous analysis is the discovery of a novel Oprm1-Fgf12-MAPK signaling pathway, which offers new insights into the mechanisms of opioid sensitivity.

   Reviewed by eLife

2. Hugin-AstA circuitry is a novel central energy sensor that directly regulates sweet sensation in Drosophila and mouse

   This article has 6 authors:

   1. Wusa Qin
   2. Tingting Song
   3. Zeliang Lai
   4. Daihan Li
   5. Liming Wang
   6. Rui Huang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work delineates layered glucose-responsive neuropeptidergic mechanisms that regulate sugar intake. Using a combination of genetic, physiological, and behavioral experiments, the authors convincingly show that Hugin- and Allatostatin A-releasing neurons suppress sugar feeding by reducing the sensitivity of Gr5a-expressing gustatory neurons. They further demonstrate that Neuromedin U neurons share key physiological properties with fly Hugin neurons, highlighting conserved peptide functions across animal phyla.

   Reviewed by eLife

3. Regulation of sensorimotor serial learning in speech production by motor compensation rather than sensory error

   This article has 6 authors:

   1. Yuhan Lu
   2. Xiaowei Tang
   3. Zhenyan Xiao
   4. Anqi Xu
   5. Junxi Chen
   6. Xing Tian

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study investigates how people adapt their speech when auditory feedback is altered. The analyses are rigorous and the work makes a valuable contribution by extending methods from limb motor control to speech. However, because the paradigm does not directly measure sensory error, the evidence for the proposed mechanism of sensorimotor learning is incomplete. The findings are best viewed as evidence for how prior motor adjustments influence subsequent behaviour, highlighting the need for future studies to more precisely separate sensory and motor contributions to adaptation.

   Reviewed by eLife

4. A comprehensive mechanosensory connectome reveals a somatotopically organized neural circuit architecture controlling stimulus-aimed grooming of the Drosophila head

   This article has 5 authors:

   1. Steven A Calle-Schuler
   2. Alexis E Santana-Cruz
   3. Lucia Kmecová
   4. Stefanie Hampel
   5. Andrew M Seeds

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study extends prior work on head bristle mechanosensation by delivering a synaptic-resolution map of second-order partners that preserves somatotopy and highlights a cholinergic pathway linking sensory input to grooming circuits, providing a valuable resource for the field. The reconstructions and quantitative connectivity analyses provide solid support the main anatomical claims, while causal sufficiency for the behavioral sequence remains inferential and could be strengthened by a simple rank-order test relating wiring to the known grooming hierarchy.

   Reviewed by eLife

5. Direct contact between iPSC-derived macrophages and hepatocytes drives reciprocal acquisition of Kupffer cell identity and hepatocyte maturation

   This article has 13 authors:

   1. Christopher Zhe Wei Lee
   2. Farah Tasnim
   3. Xiaozhong Huang
   4. Raman Sethi
   5. Yoohyun Song
   6. Tatsuya Kozaki
   7. Sebastiaan De Schepper
   8. Nicholas Ang
   9. Ivy Low
   10. You Yi Hwang
   11. Jinmiao Chen
   12. Hanry Yu
   13. Florent Ginhoux

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This timely and fundamental study introduces a human iPSC-based co-culture system that models Kupffer cell-hepatocyte interactions and aims to recapitulate liver-specific immune-parenchymal dynamics. Direct contact between iMacs and iHeps promotes mutual tissue-specific maturation, with iHeps downregulating fetal genes while iMacs acquire a Kupffer cell-like profile. This convincing in vitro model holds significant promise and is a leap forward; future experimental understanding will enhance its translational impact.

   Reviewed by eLife

6. Early exercise disrupts a pro-repair extracellular matrix program during zebrafish fin regeneration

   This article has 5 authors:

   1. Victor M Lewis
   2. Rafael A Fernandez
   3. Samuel G Horst
   4. Carlos A Gonzalez
   5. Kryn Stankunas

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The results in this study are useful because they begin to establish a causal link between physical activity and the cellular mechanisms of regeneration. The evidence presented is largely solid, supporting the conclusion that exercise-induced changes in the extracellular matrix disrupt regeneration; however, some claims are incomplete, requiring additional controls and a clearer distinction between the effects of mechanical loading and mechanical injury to the blastema. The work will be of interest to researchers in regenerative medicine.

   Reviewed by eLife

7. Rejuvenation-Responsive and Senolytic-Sensitive Muscle Stem Cells Unveiled by CD200 and CD63 in Geriatric Muscle

   This article has 13 authors:

   1. Ye Lynne Kim
   2. Young-Woo Jo
   3. Takwon Yoo
   4. Kyusang Yoo
   5. Ji-Hoon Kim
   6. Myungsun Park
   7. In-Wook Song
   8. Hyun Kim
   9. Yea-Eun Kim
   10. Sang-Hyeon Hann
   11. Jong-Eun Park
   12. Daehyun Baek
   13. Young-Yun Kong

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides valuable insights into aged muscle stem cell biology by revealing phenotypic and functional heterogeneity within the geriatric MuSC pool and proposing a VCam-low/negative subpopulation that may account for the reported decline in MuSC numbers with age. These findings have implications for understanding aging-related changes in stem cell maintenance and for improving strategies to isolate or rejuvenate aged MuSCs. However, the evidence supporting the main claims is incomplete, key analyses such as absolute MuSC quantification, fate assessment of VCam-low/negative cells, inclusion of standard aged cohorts, and validation of proposed surface markers are still needed to confirm that overall MuSC abundance is maintained and that a distinct subpopulation has been identified.

   Reviewed by eLife

8. Contrasting roles for IKK-regulated inflammatory signalling pathways for development and maintenance of type 1 and adaptive γδ T cells

   This article has 6 authors:

   1. Farjana Islam
   2. Cayman Williams
   3. Thea Hogan
   4. Louise V Webb
   5. Ines Boal-Carvalho
   6. Benedict Seddon

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study reports important findings regarding the role of the NF-kB signaling pathway in the development and long-term survival of gamma delta T cells. The authors report disparate roles of IKK-dependent NF-kB activation in the development and long-term survival of gamma delta T cell subsets. The approach and methodology employed is convincing. This work will be of great interest to immunologists interested in innate-like T cell biology and in T cell development.

   Reviewed by eLife

9. Long-range inhibitory axons from medial entorhinal cortex target lateral entorhinal neurons projecting to the hippocampal formation

   This article has 5 authors:

   1. Eirik S Nilssen
   2. Bente Jacobsen
   3. Thanh P Doan
   4. Paulo JB Girão
   5. Menno P Witter

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides a valuable insight into how the medial and lateral entorhinal cortices interact through distinct excitatory and inhibitory pathways. Using anatomical tracing, optogenetics, and electrophysiology, the authors show that glutamatergic medial entorhinal neurons provide broad excitatory input to lateral entorhinal, while long-range SST+ interneurons deliver selective inhibition to layer I. These findings reveal a novel layer- and cell-type-specific organization of medial to lateral entorhinal connectivity with implications for spatial and episodic memory. The work is solid, but validation of injection specificity and viral spread is needed to fully confirm the anatomical interpretations; with these clarifications, this will be a significant contribution to understanding entorhinal-hippocampal circuit organization.

   Reviewed by eLife

10. DNA tensiometer reveals catch-bond detachment kinetics of kinesin-1, -2 and -3

    This article has 5 authors:

    1. Crystal R Noell
    2. Tzu-Chen Ma
    3. Rui Jiang
    4. Scott A McKinley
    5. William O Hancock

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      The authors use a convincing methodology to investigate the detachment and reattachment kinetics of kinesin-1, 2, and 3 motors against loads oriented parallel to the microtubule. The findings are useful to the field in providing a clearer view of kinesin function under load. However, as the manuscript stands, the conclusions drawn from the experiments, as well as the overall interpretation of the results, are only partially supported by the presented data, and the novelty relative to previous reports appears less clear.

    Reviewed by eLife