eLife

Latest preprint reviews

1. Phasic and tonic pain serve distinct functions during adaptive behaviour

   This article has 5 authors:

   1. Shuangyi Tong
   2. Timothy Denison
   3. Danielle Hewitt
   4. Sang Wan Lee
   5. Ben Seymour

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The article presents important findings of a dissociation between phasic and tonic pain functions in adaptive behavior, combining immersive VR, computational modeling, skin conductance, and EEG data. The methodology used is solid. Its ecological design and sophisticated computational modeling are major strengths. The article would benefit from adding details on hypotheses, VR implementation, sample size determination, modeling, analysis, and pain specificity.

   Reviewed by eLife

2. The zoo of the gene networks capable of pattern formation by extracellular signaling

   This article has 2 authors:

   1. Kevin Martinez-Anhom
   2. Isaac Salazar-Ciudad

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study presents valuable theoretical insights by attempting to classify pattern-forming gene subnetworks and exploring their potential mechanisms. However, the results are incomplete, as they rely on oversimplified models, limited classifications, and assumptions that may not hold in more complex or realistic scenarios.

   Reviewed by eLife

3. Extrusion-modulated DnaA activity oscillations coordinate DNA replication with biomass growth

   This article has 11 authors:

   1. Dengjin Li
   2. Hai Zheng
   3. Yang Bai
   4. Zheng Zhang
   5. Hao Cheng
   6. Xiongliang Huang
   7. Ting Wei
   8. Matthew Chang
   9. Arieh Zaritsky
   10. Terence Hwa
   11. Chenli Liu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This work provides high-precision single-cell data on the relationship between DnaA activity and cell size, offering important insights for the field of cell cycle control. These findings motivate a novel and intriguing hypothesis for DNA replication initiation -the "extrusion model"- in which DNA-binding proteins modulate free DnaA availability in response to biomass-DNA imbalance. While the current indirect evidence does not fully establish the model, an experimental perturbation involving H-NS offers convincing support for its plausibility, laying the groundwork for future investigation.

   Reviewed by eLife

4. Mycobacterium tuberculosis partitions the Krebs cycle to persist under iron starvation

   This article has 5 authors:

   1. Agnese Serafini
   2. Acely Garza-Garcia
   3. Davide Sorze
   4. Luiz Pedro Sorio de Carvalho
   5. Riccardo Manganelli

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This well-designed, valuable study uses isotope tracing to analyse how iron limitation alters TCA cycle metabolism in Mycobacterium tuberculosis, revealing potential antibiotic targets for non-replicating bacteria in the host. The findings provide insights into metabolic remodelling under iron-limited conditions. Whilst some of the evidence is solid, the data around the GABA shunt is incomplete, requiring genetic validation, as was done for the glyoxylate shunt. Questions remain about the underlying mechanisms and their specific role in M. tuberculosis pathogenesis.

   Reviewed by eLife

5. Degradation of LMO2 in T cell leukaemia results in collateral breakdown of transcription complex partners and causes LMO2-dependent apoptosis

   This article has 8 authors:

   1. Naphannop Sereesongsaeng
   2. Carole Bataille
   3. Angela Russell
   4. Nicolas Bery
   5. Fernando J Sialana
   6. Jyoti Choudhary
   7. Ami Miller
   8. Terence Rabbitts

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important paper reports the development of proteins and small molecules that induce degradation of a clinically-relevant oncogenic transcription factor, LMO2. The findings provide a proof of concept that PROTAC-type chemicals can be developed against intrinsically disordered proteins. The methods provide a blueprint for rational design of PROTACs starting from intracellular antibody paratopes. Overall, the paper is supported by solid evidence and will be of interest to chemical biologists and cancer pharmacologists.

   Reviewed by eLife

6. Endoscopic liquid biopsies of gastric fluid in a large human patient cohort reveal DNA content as a candidate tumor biomarker in gastric cancer

   This article has 25 authors:

   1. Francine C Cadoná
   2. Thais F Bartelli
   3. Adriane G Pelosof
   4. Claudia Z Sztokfisz
   5. Adriana P Bueno
   6. Luana Batista do Carmo dos Santos
   7. Gabriela P Branco
   8. Gabriel Oliveira dos Santos
   9. Warley A Nunes
   10. Fernanda A Pintor
   11. Laís Lie Senda de Abrantes
   12. Alexandre Defelicibus
   13. Luiz Gonzaga Vaz Coelho
   14. Marcis Leja
   15. Haejin In
   16. Sharon Li
   17. Howard Hochster
   18. Felipe JF Coimbra
   19. Rodrigo Drummond
   20. Israel Tojal Da Silva
   21. Ravi J Chokshi
   22. Renata Pasqualini
   23. Wadih Arap
   24. Diana N Nunes
   25. Emmanuel Dias-Neto

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable work substantially advances our understanding of prognostic value of total gfDNA in gastric cancer. The evidence supporting the conclusions is solid, supported by a large, well-classified patient cohort and controlled clinical variables. The work will be of broad interest to scientists and clinical pathologist working in the field of gastric cancer.

   Reviewed by eLife

7. An evolutionarily conserved scheme for reformatting odor concentration in early olfactory circuits

   This article has 4 authors:

   1. Yang Shen
   2. Arkarup Banerjee
   3. Dinu F Albeanu
   4. Saket Navlakha

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is a valuable computational study of odor responses in the early olfactory system of insects and vertebrates. The study addresses the question of how information about odor concentration is encoded by second-order neurons in the invertebrate and vertebrate olfactory system; it offers insights into the transformation of neural signals from receptors to second-order neurons. While reanalysis of published data presents solid evidence supporting compression of concentration information, incomplete analysis is provided to resolve how this observation could be reconciled with the need to preserve information about changes in stimulus intensity. This work will be of interest to neuroscientists studying sensory processing broadly and olfaction specifically.

   Reviewed by eLife

8. Characterisation of cell-scale signalling by the core planar polarity pathway during Drosophila wing development

   This article has 3 authors:

   1. Alexandre Carayon
   2. Helen Strutt
   3. David Strutt

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful paper examined the mechanism of planar cell polarity (PCP) using Drosophila pupal wing, investigating how 'cellular level', 'molecular level' and 'tissue level' mechanisms intersect to establish PCP. This represents progress for the field and the conclusions are mostly backed up by solid data. Whereas the manuscript is sound overall, remaining concerns could be addressed by textual clarification of the concepts used in the manuscript.

     [Editors' note: this paper was reviewed by Review Commons and revised by the authors.]

   Reviewed by eLife

9. Life-history trade-offs explain local adaptation in Arabidopsis thaliana

   This article has 21 authors:

   1. Benjamin Brachi
   2. Danièle L Filiault
   3. Rahul Pisupati
   4. Tal Dahan-Meir
   5. Anna Igolkina
   6. Alison Anastasio
   7. Mathew S Box
   8. Susan Duncan
   9. Talia L Karasov
   10. Envel Kerdaffrec
   11. Laura Merwin
   12. Timothy C Morton
   13. Viktoria Nizhynska
   14. Polina Yu Novikova
   15. Fernando Rabanal
   16. Takashi Tsuchimatsu
   17. Torbjörn Säll
   18. Caroline Dean
   19. Svante Holm
   20. Joy Bergelson
   21. Magnus Nordborg

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript reports a large series of experiments to investigate specific aspects of plant adaptation, leveraging genetic and genomic resources of Arabidopsis thaliana. The study provides convincing evidence for local adaptation in this highly selfing plant. This is an important dataset contributing to the developing understanding of non-linear selection in plants and beyond.

   Reviewed by eLife

10. Life-cycle-related gene expression patterns in the brown algae

    This article has 5 authors:

    1. Pélagie Ratchinski
    2. Olivier Godfroy
    3. Benjamin Noel
    4. Jean-Marc Aury
    5. J Mark Cock

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This manuscript presents an in-depth analysis of gene expression across multiple brown algal species with differing life histories, providing convincing evidence for the conservation of life cycle-specific gene expression. While largely descriptive, the study is an important step forward in understanding the core cellular processes that differ between life cycle phases, and its findings will be of broad interest to developmental and evolutionary biologists.

    Reviewed by eLife