eLife

Latest preprint reviews

1. A spinal synergy of excitatory and inhibitory neurons coordinates ipsilateral body movements

   This article has 10 authors:

   1. Marito Hayashi
   2. Miriam Gullo
   3. Gokhan Senturk
   4. Stefania Di Costanzo
   5. Shinji C. Nagasaki
   6. Ryoichiro Kageyama
   7. Itaru Imayoshi
   8. Martyn Goulding
   9. Samuel L. Pfaff
   10. Graziana Gatto

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study makes important contributions to our understanding of spinal locomotor circuits by manipulating the function of excitatory and inhibitory V2 interneurons and revelaing their role in locomotor control. The data collected and the methods used by the authors are solid and the authors suggest that V2 excitatory and inhibitory neurons have antagonistic functions in intralimb coordination. This work will be of broad interest for neuroscientists studying development and function of motor circuits.

   Reviewed by eLife

2. The unique synaptic circuitry of specialized olfactory glomeruli in Drosophila melanogaster

   This article has 8 authors:

   1. Lydia Gruber
   2. Rafael Cantera
   3. Markus William Pleijzier
   4. Martin Niebergall
   5. Michael Steinert
   6. Thomas Pertsch
   7. Bill S Hansson
   8. Jürgen Rybak

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study seeks to determine how synaptic relationships between principal cell types in the olfactory system vary with glomerulus selectivity and is therefore valuable to the field. The methodology is solid, and with the caveat that here was a technical need to group all local interneurons, centrifugal neurons and multiglomerular projection neurons into one category ("multiglomerular neurons"), this work reveals some very interesting potential differences in circuit architecture associated with glomerular tuning breadth.

   Reviewed by eLife, preLights

3. Unifying network model links recency and central tendency biases in working memory

   This article has 4 authors:

   1. Vezha Boboeva
   2. Alberto Pezzotta
   3. Claudia Clopath
   4. Athena Akrami

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study combines disparate results from both psychophysics and neural silencing experiments to suggest a new interpretation of how animals and humans represent and interpret recent events in our memory. A key aspect of the model put forward here is the presence of discrete jumps in neural activity within the posterior parietal region of the cortex. The model is distinct from other models, and the authors provide convincing evidence to support it both from existing results as well as from novel experiments.

   Reviewed by eLife

4. Hexokinase regulates Mondo-mediated longevity via the PPP and organellar dynamics

   This article has 10 authors:

   1. Raymond Laboy
   2. Marjana Ndoci
   3. Shamsh Tabrez Syed
   4. Maximilian Vonolfen
   5. Eugen Ballhysa
   6. Tim Droth
   7. Klara Schilling
   8. Anna Loehrke
   9. Ilian Atanassov
   10. Adam Antebi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study utilizes the nematode C. elegans and mammalian cell culture to investigate the role of MML-1/Mondo in conserved regulation of metabolism and aging. The evidence supporting the conclusions is convincing and covers a range of areas including localization, upstream pathways, and conservation. The paper will be of interest to a broad range of biologists studying aging, metabolism, and transcriptional regulation.

   Reviewed by eLife

5. Autotrophic growth of Escherichia coli is achieved by a small number of genetic changes

   This article has 13 authors:

   1. Roee Ben Nissan
   2. Eliya Milshtein
   3. Vanessa Pahl
   4. Benoit de Pins
   5. Ghil Jona
   6. Dikla Levi
   7. Hadas Yung
   8. Noga Nir
   9. Dolev Ezra
   10. Shmuel Gleizer
   11. Hannes Link
   12. Elad Noor
   13. Ron Milo

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important follow-up study to a previous paper in which the authors reconstituted CO2 metabolism (autotrophy) in Escherichia coli. Here, the authors define a set of just three mutations that promote autotrophy, highlighting the malleability of E. coli metabolism. The authors make a convincing case that mutations in pgi are loss-of-function mutations that prevent metabolic efflux from the reductive pentose phosphate autocatalytic cycle, and their data suggest possible roles of mutations in two other genes - crp and rpoB. This research will be particularly interesting to synthetic biologists, systems biologists, and metabolic engineers aiming to develop synthetic autotrophic microorganisms.

   Reviewed by eLife

6. Deep Learning Using High-Resolution Images of Forearm Predicts Fracture

   This article has 10 authors:

   1. Roland Chapurlat
   2. Serge Ferrari
   3. Xiaoxu Li
   4. Yu Peng
   5. Min Xu
   6. Min Bui
   7. Elisabeth Sornay-Rendu
   8. Eric lespessailles
   9. Emmanuel Biver
   10. Ego Seeman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a valuable deep learning-based model for predicting fracture within the next five years from just a standard distal radius and ulna scan obtained using high-resolution computed tomography images. The evidence supporting the conclusion that the model-predicted fracture prediction score can be used clinically to identify women at risk of fracture more effectively than with the current standard clinical approach is convincing. This work will be of interest to biomechanists and biomedical engineers working on osteoporosis.

   Reviewed by eLife

7. Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia

   This article has 26 authors:

   1. Tobias Weinberger
   2. Messerer Denise
   3. Markus Joppich
   4. Maximilian Fischer
   5. Clarisabel Garcia Rodriguez
   6. Konda Kumaraswami
   7. Vanessa Wimmler
   8. Sonja Ablinger
   9. Saskia Räuber
   10. Jiahui Fang
   11. Lulu Liu
   12. Wing Han Liu
   13. Julia Winterhalter
   14. Johannes Lichti
   15. Lukas Thomas
   16. Dena Esfandyari
   17. Guelce Percin
   18. Sandra Matin
   19. Andrés Hidalgo
   20. Claudia Waskow
   21. Stefan Engelhardt
   22. Andrei Todica
   23. Ralf Zimmer
   24. Clare Pridans
   25. Elisa Gomez Perdiguero
   26. Christian Schulz

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Using state-of-the-art fate-mapping models and genetic and pharmacological targeting approaches, this study provides important findings on the distinct functions exerted by resident and recruited macrophages during cardiac healing after myocardial ischemia. Evidence supporting the conclusions are solid with the use of the FIRE mouse model in combination with fate-mapping to target fetal-derived macrophages. This study will be of interest for the macrophage biologists working in the heart but also in others tissues in the context of inflammation.

   Reviewed by eLife

8. Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expression

   This article has 15 authors:

   1. Mattia Privitera
   2. Lukas M von Ziegler
   3. Amalia Floriou-Servou
   4. Sian N Duss
   5. Runzhong Zhang
   6. Rebecca Waag
   7. Sebastian Leimbacher
   8. Oliver Sturman
   9. Fabienne K Roessler
   10. Annelies Heylen
   11. Yannick Vermeiren
   12. Debby Van Dam
   13. Peter P De Deyn
   14. Pierre-Luc Germain
   15. Johannes Bohacek

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important paper uses a multifaceted approach to implicate the locus coeruleus-noradrenaline system in the stress-induced transcriptional changes of dorsal and ventral hippocampus. It provides an inventory of dorsal and ventral hippocampal gene expression upregulated by activation of LC-NA system, which can be used as starting point for more functional studies related to the effects of stress-induced physiological and pathological changes. The results convincingly support the conclusions. This paper will be of interest to those interested in stress neurobiology, hippocampal, and/or noradrenaline function.

   Reviewed by eLife

9. Plasma extracellular vesicle synaptic proteins as biomarkers of clinical progression in patients with Parkinson’s disease

   This article has 4 authors:

   1. Chien-Tai Hong
   2. Chen-Chih Chung
   3. Ruan-Ching Yu
   4. Lung Chan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This useful study presents data regarding the presence of synaptic proteins in the extracellular vesicle pool present in the blood of Parkinson's patients and non-parkinson neurological outpatients, trying to correlate changes in such levels with the progression of Parkinson's symptoms. The results are semi-quantitative and preliminary, suggesting that these biomarkers could be used in the follow up of a specific group of Parkinson patients. The evidence is incomplete at this point, and more quantitative approaches are required to propose this correlation. The isolation of extracellular vesicles was appropriate as revealed by their sizes, but they are not exclusively from neuronal origin. The presented approach is not ready to be used in the clinical setting.

   Reviewed by eLife

10. Stochastic characterization of navigation strategies in an automated variant of the Barnes maze

    This article has 3 authors:

    1. Ju-Young Lee
    2. Dahee Jung
    3. Sebastien Royer

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This study presents a valuable new behavioral apparatus aimed at differentiating the strategies animals use to orient themselves in an environment. The evidence supporting the claims is solid, with statistical modeling of animal behavior. Overall, this study will attract the interest of researchers exploring spatial learning and memory.

    Reviewed by eLife