eLife

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1. Asymmetric distribution of color-opponent response types across mouse visual cortex supports superior color vision in the sky

   This article has 7 authors:

   1. Katrin Franke
   2. Chenchen Cai
   3. Kayla Ponder
   4. Jiakun Fu
   5. Sacha Sokoloski
   6. Philipp Berens
   7. Andreas Savas Tolias

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Franke et al. explore and characterize color response properties of neurons in mouse primary visual cortex (V1), revealing specific color opponent encoding strategies across the visual field. The paper provides evidence for the existence of color opponency in a subset of neurons within V1 and shows that these color opponent neurons are more numerous in the upper visual field. Support for the main conclusions is convincing and the dataset that forms the basis of the paper is impressive. The paper will make an important contribution to understanding how color is coded in mouse V1.

   Reviewed by eLife

2. Semaphorin7A patterns neural circuitry in the lateral line of the zebrafish

   This article has 6 authors:

   1. Agnik Dasgupta
   2. Caleb C Reagor
   3. Sang Peter Paik
   4. Lauren M Snow
   5. Adrian Jacobo
   6. AJ Hudspeth

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The valuable findings by Dasgupta et al demonstrate the role of Sema7a in fine tuning the morphology of the microcircuit between afferent axons and sensory hair cells in the lateral line organ. The loss and gain of function evidence provides solid support for a role for Sema7a in this process. Additional work is needed to determine the role for different isoforms in Sema7a-mediated synapse formation and chemoattraction as well as cell type specificity.

   Reviewed by eLife

3. Large-scale characterization of cocaine addiction-like behaviors reveals that escalation of intake, aversion-resistant responding, and breaking-points are highly correlated measures of the same construct

   This article has 38 authors:

   1. Giordano de Guglielmo
   2. Lieselot Carrette
   3. Marsida Kallupi
   4. Molly Brennan
   5. Brent Boomhower
   6. Lisa Maturin
   7. Dana Conlisk
   8. Sharona Sedighim
   9. Lani Tieu
   10. McKenzie J Fannon
   11. Angelica R Martinez
   12. Nathan Velarde
   13. Dyar Othman
   14. Benjamin Sichel
   15. Jarryd Ramborger
   16. Justin Lau
   17. Jenni Kononoff
   18. Adam Kimbrough
   19. Sierra Simpson
   20. Lauren C Smith
   21. Kokila Shankar
   22. Selene Bonnet-Zahedi
   23. Elizabeth A Sneddon
   24. Alicia Avelar
   25. Sonja Lorean Plasil
   26. Joseph Mosquera
   27. Caitlin Crook
   28. Lucas Chun
   29. Ashley Vang
   30. Kristel K Milan
   31. Paul Schweitzer
   32. Bonnie Lin
   33. Beverly Peng
   34. Apurva S Chitre
   35. Oksana Polesskaya
   36. Leah C Solberg Woods
   37. Abraham A Palmer
   38. Olivier George

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript tackles a significant problem in addiction science: how interdependent are measures of "addiction-like" behavioral phenotypes? The manuscript provides compelling evidence that, under these experimental conditions, escalation of intake, punishment-resistant responding, and progressive ratio break points reflect a single underlying construct rather than reflect distinct unrelated measures. The exceptionally large sample size and incorporation of multiple behavioral endpoints add strength to this paper, and make it an important resource for the field.

   Reviewed by eLife

4. RETRACTED: PAK3 downregulation induces cognitive impairment following cranial irradiation

   This article has 4 authors:

   1. Haksoo Lee
   2. Hyunkoo Kang
   3. Changjong Moon
   4. BuHyun Youn

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The study investigates the functional impact of cranial irradiation in mouse and proposes PAK3 as molecular element involved in radiation-induced cognitive decrement. The significance of the findings is useful for fields covering radiation, brain tumor and cognition. The strength of evidence is solid, although the referees expressed divergent views on the manuscript.

   Reviewed by eLife

5. Associative memory neurons of encoding multi-modal signals are recruited by neuroligin-3-mediated new synapse formation

   This article has 5 authors:

   1. Yang Xu
   2. Tian-liang Cui
   3. Jia-yi Li
   4. Bingchen Chen
   5. Jin-Hui Wang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Multimodal experiences that for example contain both visual and tactile components are encoded as associative memories. This manuscript is a valuable contribution supporting structural and functional brain plasticity following associative training protocols that pair together different types of sensory stimuli. The results provide solid support for this plasticity being a basis for cross-modal associative memories.

   Reviewed by eLife

6. Cortical plasticity is associated with blood–brain barrier modulation

   This article has 13 authors:

   1. Evyatar Swissa
   2. Uri Monsonego
   3. Lynn T Yang
   4. Lior Schori
   5. Lyna Kamintsky
   6. Sheida Mirloo
   7. Itamar Burger
   8. Sarit Uzzan
   9. Rishi Patel
   10. Peter H Sudmant
   11. Ofer Prager
   12. Daniela Kaufer
   13. Alon Friedman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study builds upon previous work which demonstrated that brain injury results in the entry of a protein called albumin into the brain which then causes diverse effects. The present study shows that prolonged stimulation of a forelimb in a rat leads to albumin entry, and is associated with effects that suggest plasticity is enhanced in the stimulated side of the brain. The strength of evidence was convincing and results are important because they suggest a previously-considered pathological process may be relevant to the normal brain and have benefits.

   Reviewed by eLife

7. Vglut2-based glutamatergic signaling in central noradrenergic neurons is dispensable for normal breathing and chemosensory reflexes

   This article has 5 authors:

   1. Yuan Chang
   2. Savannah Lusk
   3. Andersen Chang
   4. Christopher S Ward
   5. Russell S Ray

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Chang et al. provide glutamate co-expression profiles in the central noradrenergic system and test the requirement of Vglut2-based glutamatergic release in respiratory and metabolic activity under physiologically relevant gas challenges. Their experiments provide compelling evidence that conditional deletion of vesicular glutamate transporters from noradrenergic neurons does not impact steady-state breathing or metabolic activity in room air, hypercapnia, or hypoxia. This study provides an important contribution to our understanding of how noradrenergic neurons regulate respiratory homeostasis in conscious adult mice.

   Reviewed by eLife

8. Statistical examination of shared loci in neuropsychiatric diseases using genome-wide association study summary statistics

   This article has 8 authors:

   1. Thomas P Spargo
   2. Lachlan Gilchrist
   3. Guy P Hunt
   4. Richard JB Dobson
   5. Petroula Proitsi
   6. Ammar Al-Chalabi
   7. Oliver Pain
   8. Alfredo Iacoangeli

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper presents a valuable pipeline based on state-of-the-art analytical software that was used to study genetic pleiotropy between neuropsychiatric disorders. The presented evidence supporting the claims is convincing and now includes an appropriate comparison to previously published methods as well as a detailed exploration of the findings. The created pipeline can thus be used by researchers from diverse fields to study different combinations of diseases and traits.

   Reviewed by eLife

9. Heterogeneity of radial spokes structural components and associated enzymes in Tetrahymena cilia

   This article has 10 authors:

   1. Marta Bicka
   2. Corbin Black
   3. Avrin Ghanaeian
   4. Ewa Joachimiak
   5. Anna Osinka
   6. Sumita Majhi
   7. Anna Konopka
   8. Ewa Bulska
   9. Khanh Huy Bui
   10. Dorota Wloga

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents valuable new insights from the protist Tetrahymena regarding radial spokes, conserved protein complexes that are relevant for cilia motility. The work employs interdisciplinary approaches to provide convincing support for radial spoke composition with some experiments, but there are weaker areas with partially incomplete support, such as relying on knockouts alone rather than including localization studies of tagged proteins.

   Reviewed by eLife

10. Oxygen isotopes in orangutan teeth reveal recent and ancient climate variation

    This article has 12 authors:

    1. Tanya M Smith
    2. Manish Arora
    3. Christine Austin
    4. Janaína Nunes Ávila
    5. Mathieu Duval
    6. Tze Tshen Lim
    7. Philip J Piper
    8. Petra Vaiglova
    9. John de Vos
    10. Ian S Williams
    11. Jian-xin Zhao
    12. Daniel R Green

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This important study presents convincing evidence for the use of orangutan teeth as terrestrial proxies to reconstruct rainfall regimes, while exploring the potentially conflicting impact of breastfeeding signals. The findings will be of broad interest for those using and developing methods and tools to reconstruct environmental conditions in the historical and archaeological past.

    Reviewed by eLife