Latest preprint reviews

  1. Activin A marks a novel progenitor cell population during fracture healing and reveals a therapeutic strategy

    This article has 12 authors:
    1. Lutian Yao
    2. Jiawei Lu
    3. Leilei Zhong
    4. Yulong Wei
    5. Tao Gui
    6. Luqiang Wang
    7. Jaimo Ahn
    8. Joel D Boerckel
    9. Danielle Rux
    10. Christina Mundy
    11. Ling Qin
    12. Maurizio Pacifici
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This work is a valuable presentation of sharp-wave-ripple reactivation of hippocampal neural ensemble activity recorded as animals explored two different environments. It attempts to use the fact that the ensemble code remaps between the two mazes to identify the best replay-detection procedures for analyzing this type of data. The reviewers found the evidence for a prescriptive conclusion inadequate, while still appreciating the concept of comparing maze-identity discrimination with replay.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Exonuclease Xrn1 regulates TORC1 signaling in response to SAM availability

    This article has 4 authors:
    1. Madeline M. McGinnis
    2. Benjamin M. Sutter
    3. Samira Jahangiri
    4. Benjamin P. Tu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study in budding yeast (S. cerevisiae) presents important findings demonstrating that the exonuclease Xrn1 regulates autophagy in response to methionine deprivation through effects on TORC1. There is solid evidence that the impact of Xrn1 on TORC1 is contingent on its catalytic activity rather than the degradation of any specific category of mRNAs. A major strength is the novel mechanism, in which Xrn1 modulates the nucleotide-binding state of the Gtr1/2 complex.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
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