eLife

Latest preprint reviews

1. Synaptotagmin 7 docks synaptic vesicles to support facilitation and Doc2α-triggered asynchronous release

   This article has 8 authors:

   1. Zhenyong Wu
   2. Grant F Kusick
   3. Manon MM Berns
   4. Sumana Raychaudhuri
   5. Kie Itoh
   6. Alexander M Walter
   7. Edwin R Chapman
   8. Shigeki Watanabe

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this important study, the authors identify distinct roles for the calcium sensors Synaptotagmin 7 and Doc2alpha in the regulation of asynchronous release and calcium-dependent synaptic vesicle docking in hippocampal neurons. The current work adds to the field by placing the role of the two proteins in a new context, where Synaptotagmin 7 acts to promote synaptic vesicle docking and capture after a stimulus, while Doc2alpha has a role in specifically driving the asynchronous component of release as a calcium sensor. The methods, data, and analyses provide convincing support for the conclusions.

   Reviewed by eLife

2. Neuronal NPR-15 modulates molecular and behavioral immune responses via the amphid sensory neuron-intestinal axis in C. elegans

   This article has 3 authors:

   1. Benson Otarigho
   2. Anna Frances Butts
   3. Alejandro Aballay

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The important work by Aballay et al. significantly advances our understanding of how G protein-coupled receptors (GPCRs) regulate immunity and pathogen avoidance. The authors provide convincing evidence for the GPCR NPR-15 to mediate immunity by altering the activity of several key transcription factors. This work will be of broad interest to immunologists.

   Reviewed by eLife

3. Ym1 protein crystals promote type 2 immunity

   This article has 10 authors:

   1. Ines Heyndrickx
   2. Kim Deswarte
   3. Kenneth Verstraete
   4. Koen HG Verschueren
   5. Ursula Smole
   6. Helena Aegerter
   7. Ann Dansercoer
   8. Hamida Hammad
   9. Savvas N Savvides
   10. Bart N Lambrecht

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important and interesting account of the ability of Ym1 crystals to promote type 2 immunity in vivo, in mice. The data presented are compelling, building on and significantly advancing evidence this group has previously published on the type 2 immunogenicity of other protein crystals. The work will be of relevant interest to immunologists and researchers working on type 2 inflammatory disease, in the lung and in others tissues.

   Reviewed by eLife

4. A novel machine learning algorithm selects proteome signature to specifically identify cancer exosomes

   This article has 3 authors:

   1. Bingrui Li
   2. Fernanda G Kugeratski
   3. Raghu Kalluri

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study introduces a novel AI method for the analysis of published data, with practical implications for early cancer diagnosis. The results are supported by compelling evidence.

   Reviewed by eLife

5. Exploration of drug resistance mechanisms in triple negative breast cancer cells using a microfluidic device and patient tissues

   This article has 15 authors:

   1. Wanyoung Lim
   2. Inwoo Hwang
   3. Jiande Zhang
   4. Zhenzhong Chen
   5. Jeonghun Han
   6. Jaehyung Jeon
   7. Bon-Kyoung Koo
   8. Sangmin Kim
   9. Jeong Eon Lee
   10. Youngkwan Kim
   11. Kenneth J Pienta
   12. Sarah R Amend
   13. Robert H Austin
   14. Jee-Yin Ahn
   15. Sungsu Park

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study based on the use of Cancer Drug Resistance Accelerator (CDRA) chip is valuable as a platform technology to assess chemoresistance mechanisms. The strength is convincing from the technological point of view. However, the use of a single cell line model is a limitation. However we acknowledge the authors' plan to further validate their current findings across multiple TNBC cell lines.

   Reviewed by eLife

6. Brain-imaging evidence for compression of binary sound sequences in human memory

   This article has 4 authors:

   1. Fosca Al Roumi
   2. Samuel Planton
   3. Liping Wang
   4. Stanislas Dehaene

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This article brings to bear a useful, extensive set of behavioral methods and neural data to report that activity in numerous cortical regions robustly covaries with the complexity of tone sequences encoded in memory. In its current state, the findings are solid but deserve further analysis to arrive at more convincing conclusions.

   Reviewed by eLife

7. Discovery and biological evaluation of a potent small molecule CRM1 inhibitor for its selective ablation of extranodal NK/T cell lymphoma

   This article has 11 authors:

   1. He Liu
   2. Meisuo Liu
   3. Xibao Tian
   4. Haina Wang
   5. Jiujiao Gao
   6. Hanrui Li
   7. Zhehuan Zhao
   8. Yu Liu
   9. Caigang Liu
   10. Xuan Chen
   11. Yongliang Yang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study reports a valuable finding on the discovery and evaluation of a potent small molecule inhibitor for CRM1 that may be important to treat extranodal NK/T cell lympohma (ENKTL). The evidence supporting the claims of the authors is solid that reflects an important finding for novel CRM1 inhibitors to treat ENKTL, although additional experimental evidence is needed. The work will be of interest to cancer biologists working on ENKTL.

   Reviewed by eLife

8. Cystatin F (Cst7) drives sex-dependent changes in microglia in an amyloid-driven model of Alzheimer’s disease

   This article has 15 authors:

   1. Michael JD Daniels
   2. Lucas Lefevre
   3. Stefan Szymkowiak
   4. Alice Drake
   5. Laura McCulloch
   6. Makis Tzioras
   7. Jack Barrington
   8. Owen R Dando
   9. Xin He
   10. Mehreen Mohammad
   11. Hiroki Sasaguri
   12. Takashi Saito
   13. Takaomi C Saido
   14. Tara L Spires-Jones
   15. Barry W McColl

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a valuable finding on the function of the gene Cst7 in sex-divergent pathological changes in microglia in a mouse model of AB-driven Alzheimer's disease. The evidence supporting the claims of the authors is solid, although the study would be strengthened by validation of some of the key differentially expressed genes identified in RNA-sequencing experiments, and the inclusion of key controls and additional timepoints to address whether Cst7 drives disease progression or is simply upregulated as a result. The work will be of interest to neuroimmunologists and neuroscientists working on microglia and neurodegenerative disease.

   Reviewed by eLife

9. Motor actions are spatially organized in motor and dorsal premotor cortex

   This article has 2 authors:

   1. Nicholas G Chehade
   2. Omar A Gharbawie

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper measures the neural activity in reach-to-grasp and reach-only tasks using intrinsic optical imaging. The paper describes these in the relationship to the Intra-cortical micro stimulation maps of the same animals. The dataset is unique and potentially highly important. However, the claim of "clustered neural activity" is not tested against any quantifiable alternative hypothesis of non-clustered activity, and support for this idea is therefore currently incomplete.

   Reviewed by eLife

10. Estimating the true stability of the prehydrolytic outward-facing state in an ABC protein

    This article has 4 authors:

    1. Márton A Simon
    2. Iordan Iordanov
    3. Andras Szollosi
    4. László Csanády

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This study uncovers a unique feature of the nucleotide binding domain interface in human CFTR, offering valuable insights into the effects of different non-hydrolytic mutations on CFTR gating. While the evidence presented is solid, a more thorough examination of the non-hydrolytic mutants of zebrafish CFTR for comparison would strengthen the authors' claims. In the current form, more cautious interpretations of some of the data are needed. This study will be of interest to researchers in the fields of cystic fibrosis and proteins in the ATP Binding Cassette (ABC) transporter family.

    Reviewed by eLife