eLife

Latest preprint reviews

1. Risk-sensitive learning is a winning strategy for leading an urban invasion

   This article has 2 authors:

   1. Alexis J Breen
   2. Dominik Deffner

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study uses a multi-pronged empirical and theoretical approach to advance our understanding of animal cognition. It presents convincing data on how differences in learning relate to differences in the ways that male versus female animals cope with urban environments, and more generally how reversal learning may benefit animals in urban habitats.

   Reviewed by eLife

2. Replication stress-inducing ELF3 upregulation promotes BRCA1-deficient breast tumorigenesis in luminal progenitors

   This article has 12 authors:

   1. Jiadong Zhou
   2. Xiao Albert Zhou
   3. Li Hu
   4. Yujie Ma
   5. Jun Zhan
   6. Zhanzhan Xu
   7. Mei Zhou
   8. Qinjian Shen
   9. Zhaofei Liu
   10. Shaohua Ma
   11. Yuntao Xie
   12. Jiadong Wang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this fundamental study, the authors describe ELF3 as a candidate driver of luminal progenitor transformation, such that its up-regulation during replicative stress conditions and in BRCA1 deficient cells may permit cell proliferation by suppressing genome instability. While the work is certainly of interest, the supporting data remain incomplete as luminal progenitor cells could not be isolated, which would be needed in order to definitively determine whether ELF3 is a driver of transformation in these cells. Overall this paper may offer insight into mechanisms by which BRCA1 deficiency fuels breast tumorigenesis.

   Reviewed by eLife

3. A cryo-electron tomography study of ciliary rootlet organization

   This article has 2 authors:

   1. Chris van Hoorn
   2. Andrew P Carter

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The study offers a compelling molecular model for the organization of rootlets, a critical organelle that links cilia to the basal body, ensuring proper anchoring. While previous research has explored rootlet structure and organization, this study delivers an unprecedented level of resolution, valuable to the centrosome and cilia field. This research marks a significant step forward in our understanding of rootlets' molecular organization.

   Reviewed by eLife

4. Spinal neural tube formation and tail development in human embryos

   This article has 10 authors:

   1. Chloe Santos
   2. Abigail R Marshall
   3. Ailish Murray
   4. Kate Metcalfe
   5. Priyanka Narayan
   6. Sandra CP de Castro
   7. Eirini Maniou
   8. Nicholas DE Greene
   9. Gabriel L Galea
   10. Andrew J Copp

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is a fundamental study into human spinal neurulation, which substantially advances our understanding of human neural tube closure. Crucial unanswered questions in the field currently rely on model systems, not faithful to human development. The evidence provided is compelling, with a large number of specimens and the rigorous use of state-of-the-art methodology providing robustness. The work will be of broad interest to developmental biologists, embryologists, and medical professionals working on neural tube defects, and will act as a precious reference resource for future studies.

   Reviewed by eLife

5. Bone canonical Wnt signaling is downregulated in type 2 diabetes and associates with higher advanced glycation end-products (AGEs) content and reduced bone strength

   This article has 18 authors:

   1. Giulia Leanza
   2. Francesca Cannata
   3. Malak Faraj
   4. Claudio Pedone
   5. Viola Viola
   6. Flavia Tramontana
   7. Niccolò Pellegrini
   8. Gianluca Vadalà
   9. Alessandra Piccoli
   10. Rocky Strollo
   11. Francesca Zalfa
   12. Alec T Beeve
   13. Erica L Scheller
   14. Simon Y Tang
   15. Roberto Civitelli
   16. Mauro Maccarrone
   17. Rocco Papalia
   18. Nicola Napoli

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides valuable insights into understanding bone fragility in T2D patients through the use of human skeletal tissue, reinforcing previous pre-clinical studies or observational studies using serum samples that the Wnt signaling pathway may play a critical role in T2D-related bone impairment. The methods are solid, but a limited number of subjects and a small set of genes with lack of data in terms of cellular properties of skeletal tissue are viewed as weaknesses.

   Reviewed by eLife

6. Mecp2 fine-tunes quiescence exit by targeting nuclear receptors

   This article has 14 authors:

   1. Jun Yang
   2. Shitian Zou
   3. Zeyou Qiu
   4. Mingqiang Lai
   5. Qing Long
   6. Huan Chen
   7. Ping lin Lai
   8. Sheng Zhang
   9. Zhi Rao
   10. Xiaoling Xie
   11. Yan Gong
   12. Anling Liu
   13. Mangmang Li
   14. Xiaochun Bai

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study provides insights into the mechanism controlling cell cycle reentry, establishing a regulatory role for Mecp2 degradation in shifting transcription from metabolic to proliferation genes during quiescence exit. The evidence, which includes experimental data from in vitro cell culture and an in vivo injury-induced liver regeneration model, is convincing but the trigger for MeCP2 degradation and how MeCP2 differentially regulates proliferation and metabolic genes remain unclear.

   Reviewed by eLife

7. The αC-β4 loop controls the allosteric cooperativity between nucleotide and substrate in the catalytic subunit of protein kinase A

   This article has 11 authors:

   1. Cristina Olivieri
   2. Yingjie Wang
   3. Caitlin Walker
   4. Manu Veliparambil Subrahmanian
   5. Kim N Ha
   6. David Bernlohr
   7. Jiali Gao
   8. Carlo Camilloni
   9. Michele Vendruscolo
   10. Susan S Taylor
   11. Gianluigi Veglia

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study provides an example of integrating computational and experimental approaches that lead to new insights into the energy landscape of a model kinase. Compelling use of molecular dynamics simulations and NMR spectroscopy provide a conformational description of active and excited states of the kinase; one of which has not been captured in previously solved crystal structures. Overall, this comprehensive study expands our understanding of the architecture and allosteric features of the conserved bilobal kinase domain structure.

   Reviewed by eLife

8. Accurate prediction of CDR-H3 loop structures of antibodies with deep learning

   This article has 9 authors:

   1. Hedi Chen
   2. Xiaoyu Fan
   3. Shuqian Zhu
   4. Yuchan Pei
   5. Xiaochun Zhang
   6. Xiaonan Zhang
   7. Lihang Liu
   8. Feng Qian
   9. Boxue Tian

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper presents H3-OPT, a deep learning method that effectively combines existing techniques for the prediction of antibody structure. This work, supported by convincing experiments for validation, is important because the method can aid in the design of antibodies, which are key tools in many research and industrial applications.

   Reviewed by eLife

9. Syntaxin 17 recruitment to mature autophagosomes is temporally regulated by PI4P accumulation

   This article has 8 authors:

   1. Saori Shinoda
   2. Yuji Sakai
   3. Takahide Matsui
   4. Masaaki Uematsu
   5. Ikuko Koyama-Honda
   6. Jun-ichi Sakamaki
   7. Hayashi Yamamoto
   8. Noboru Mizushima

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper addresses a fundamental issue in the field of autophagy: how is a protein responsible for autophagosome-lysosome fusion recruited to mature autophagosomes but not immature ones? The work succeeds in its ambition to provide a new conceptual advance. The evidence supporting the conclusions is convincing, with fluorescence microscopy, biochemical assays, and molecular dynamics simulations. This work will be of broad interest to cell biologists and biochemists studying autophagy, and also those focusing on lipid/membrane biology.

   Reviewed by eLife

10. Inhibiting NINJ1-dependent plasma membrane rupture protects against inflammasome-induced blood coagulation and inflammation

    This article has 11 authors:

    1. Jian Cui
    2. Hua Li
    3. Dien Ye
    4. Guoying Zhang
    5. Yan Zhang
    6. Ling Yang
    7. Martha MS Sim
    8. Jeremy P Wood
    9. Yinan Wei
    10. Zhenyu Li
    11. Congqing Wu

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      The authors aim to elucidate the mechanism by which pyroptosis (through the formation of Gasdermin D (GSDMD) pores in the plasma membrane) contributes to increased release of procoagulant Tissue Factor-containing microvesicles. The data offers solid mechanistic insights as to the interplay between pyroptosis and microvesicle release with NINJ1. The study provides useful insights into the potential of targeting Ninj1 as a therapeutic strategy.

    Reviewed by eLife