eLife

Latest preprint reviews

1. Expansion-assisted selective plane illumination microscopy for nanoscale imaging of centimeter-scale tissues

   This article has 34 authors:

   1. Adam Glaser
   2. Jayaram Chandrashekar
   3. Sonya Vasquez
   4. Cameron Arshadi
   5. Rajvi Javeri
   6. Naveen Ouellette
   7. Xiaoyun Jiang
   8. Judith Baka
   9. Gabor Kovacs
   10. Micah Woodard
   11. Shamishtaa Seshamani
   12. Kevin Cao
   13. Nathan Clack
   14. Andrew Recknagel
   15. Anna Grim
   16. Pooja Balaram
   17. Emily Turschak
   18. Marcus Hooper
   19. Alan Liddell
   20. John Rohde
   21. Ayana Hellevik
   22. Kevin Takasaki
   23. Lindsey Erion Barner
   24. Molly Logsdon
   25. Chris Chronopoulos
   26. Saskia EJ de Vries
   27. Jonathan T Ting
   28. Steven Perlmutter
   29. Brian E Kalmbach
   30. Nikolai Dembrow
   31. Bosiljka Tasic
   32. R Clay Reid
   33. David Feng
   34. Karel Svoboda

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The ExA-SPIM methodology developed here and characterized and supported by convincing evidence is an important development for the field of light sheet microscopy as the new technology provides an impressive field of view making it possible to image the entire expanded mouse brain at cellular and subcellular resolution.

   Reviewed by eLife

2. Difficulty in artificial word learning impacts targeted memory reactivation and its underlying neural signatures

   This article has 2 authors:

   1. Arndt-Lukas Klaassen
   2. Björn Rasch

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides useful findings on how phonetic properties of words, i.e., their difficulty and prior knowledge, influence the outcome of targeted memory reactivation (TMR) during sleep. While these findings are supported by solid evidence, they are based on a small sample size warranting future work to shed further light on the impact of TMR in language learning.

   Reviewed by eLife

3. Analysis of foothold selection during locomotion using terrain reconstruction

   This article has 6 authors:

   1. Karl S Muller
   2. Kathryn Bonnen
   3. Stephanie M Shields
   4. Daniel P Panfili
   5. Jonathan Matthis
   6. Mary M Hayhoe

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study has the potential to substantially advance our understanding of human locomotion in complex real-world settings and opens up new approaches to studying (visually guided) behavior in natural settings outside the lab. The evidence supporting the conclusions is overall compelling. Whereas detailed analyses represent multiple ways to visualize and quantify the rich and complex natural behavior, some of the specific conclusions remain more suggestive at this point. The work will be of interest to neuroscientists, kinesiologists, computer scientists, and engineers working on human locomotion.

   Reviewed by eLife

4. Disordered regions and folded modules in CAF-1 promote histone deposition in Schizosaccharomyces pombe

   This article has 18 authors:

   1. Fouad Ouasti
   2. Maxime Audin
   3. Karine Fréon
   4. Jean-Pierre Quivy
   5. Mehdi Tachekort
   6. Elizabeth Cesard
   7. Aurélien Thureau
   8. Virginie Ropars
   9. Paloma Fernández Varela
   10. Gwenaelle Moal
   11. Ibrahim Soumana Adamou
   12. Aleksandra Uryga
   13. Pierre Legrand
   14. Jessica Andreani
   15. Raphaël Guerois
   16. Geneviève Almouzni
   17. Sarah Lambert
   18. Francoise Ochsenbein

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study advances our understanding of the machinery that couples DNA synthesis with the deposition of histone proteins onto newly synthesized DNA. A convincing array of experiments combines NMR, protein biochemistry, and in vivo analyses of Chromatin Assembly Factor-1 of fission yeast. The work is of interest to researchers in the field of chromosome/chromatin biology as well as epigenetics.

   Reviewed by eLife

5. Experience shapes chandelier cell function and structure in the visual cortex

   This article has 15 authors:

   1. Koen Seignette
   2. Nora Jamann
   3. Paolo Papale
   4. Huub Terra
   5. Ralph O Porneso
   6. Leander de Kraker
   7. Chris van der Togt
   8. Maaike van der Aa
   9. Paul Neering
   10. Emma Ruimschotel
   11. Pieter R Roelfsema
   12. Jorrit S Montijn
   13. Matthew W Self
   14. Maarten HP Kole
   15. Christiaan N Levelt

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important work shows compelling evidence that Chandelier cells in the visual cortex receive inputs most prominently from local layer 5 pyramidal neurons, only mildly inhibit L2/3 pyramidal neurons, and respond massively to visuomotor mismatch. It also indicates that visual experience in the virtual tunnel activates a plasticity mechanism in Chandelier cells which could be due to the particular visuo-motor coupling experienced in this setting, although a specific control is lacking for this conclusion. This study will be of interest to neuroscientists involved in cortical circuits, visual processing, and predictive coding research.

   Reviewed by eLife

6. Dysfunctional hippocampal-prefrontal network underlies a multidimensional neuropsychiatric phenotype following early-life seizure

   This article has 11 authors:

   1. Rafael Naime Ruggiero
   2. Danilo Benette Marques
   3. Matheus Teixeira Rossignoli
   4. Jana Batista De Ross
   5. Tamiris Prizon
   6. Ikaro Jesus Silva Beraldo
   7. Lezio Soares Bueno-Junior
   8. Ludmyla Kandratavicius
   9. Jose Eduardo Peixoto-Santos
   10. Cleiton Lopes-Aguiar
   11. Joao Pereira Leite

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study assesses anatomical, behavioral, physiological, and neurochemical effects of early-life seizures in rats, describing a striking astrogliosis and deficits in cognition and electrophysiological parameters. The solid results come from a wide range of convergent techniques that were used to understand the effects of early-life seizures on behavior as well as hippocampal prefrontal cortical dynamics. This paper will be of interest to neurobiologists, epileptologists, and behavioral scientists.

   Reviewed by eLife

7. Phasic locus coeruleus activity enhances trace fear conditioning by increasing dopamine release in the hippocampus

   This article has 7 authors:

   1. Jacob H Wilmot
   2. Cassiano RAF Diniz
   3. Ana P Crestani
   4. Kyle R Puhger
   5. Jacob Roshgadol
   6. Lin Tian
   7. Brian Joseph Wiltgen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important study examining the neural profile of weak and strong fear memories using a variety of imagining and interrogation neural techniques. The data are convincing in detailing the neural profile of neutral, aversive and fear conditioned stimuli in the LC and its input to the dorsal hippocampus and support the conclusion that dopaminergic input from the LC is the key instigator of trace fear conditioning in hippocampus. This paper is of interest to behavioural and neuroscience researchers studying learning, memory and neural networks.

   Reviewed by eLife

8. Water and chloride as allosteric inhibitors in WNK kinase osmosensing

   This article has 5 authors:

   1. Liliana R Teixeira
   2. Radha Akella
   3. John M Humphreys
   4. Haixia He
   5. Elizabeth J Goldsmith

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents an important investigation of water coordination in a specific kinase family with a focus on the regulation of osmosensing protein kinases. X-ray crystallographic approaches combined with functional assays are used to address the hypothesis that bound water participates in the osmosensing mechanism as an allosteric kinase inhibitor. The evidence for changes in kinase conformation and space group of the crystal as a function of added low molecular weight polyethylene glycol is solid. The work will be of considerable interest to the kinase field as well as colleagues studying allosteric regulation of protein function.

   Reviewed by eLife

9. H2-O deficiency promotes regulatory T cell differentiation and CD4 T cell hyperactivity

   This article has 5 authors:

   1. Robin A. Welsh
   2. Nianbin Song
   3. Chan-Su Park
   4. J. David Peske
   5. Scheherazade Sadegh-Nasseri

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper seeks to understand how the presentation of peptides by medullary thymic epithelial cells may be regulated by the MHCII peptide loading modulator, H2-O, and how this may affect the selection of regulatory T (Treg) cells. Further work is needed to ensure that the findings are robust: currently the analysis of data is inadequate and inconsistencies in the reported findings are not placed in context with results from other groups. The current version does not provide sufficient support for the claims regarding the effects on Treg cell selection.

   Reviewed by eLife

10. A Chemical Reaction Similarity-Based Prediction Algorithm Identifies the Multiple Taxa Required to Catalyze an Entire Metabolic Pathway of Dietary Flavonoids

    This article has 6 authors:

    1. Ebru Ece Gulsan
    2. Farrhin Nowshad
    3. Pomaikaimaikalani Yamaguchi
    4. Xiaokun Dong
    5. Arul Jayaraman
    6. Kyongbum Lee

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This paper reports useful findings regarding gut bacteria that metabolize dietary flavonoids, which can enhance, reduce, or otherwise alter the flavonoid bioactivities. With a newly developed bioinformatics tool, the authors predict bacterial species that can metabolize parts of the flavonoid tilianin. Formal proof of concept is missing, but if experimentally confirmed, the study will change the way we think about metabolism of flavonoids and would be of broad interest regarding gut bacterial metabolism. Most of the analyses are compelling, but others require further inquiry.

    Reviewed by eLife