eLife

Latest preprint reviews

1. Associative memory neurons of encoding multi-modal signals are recruited by neuroligin-3-mediated new synapse formation

   This article has 5 authors:

   1. Yang Xu
   2. Tian-liang Cui
   3. Jia-yi Li
   4. Bingchen Chen
   5. Jin-Hui Wang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Multimodal experiences that for example contain both visual and tactile components are encoded as associative memories. This manuscript is a valuable contribution supporting structural and functional brain plasticity following associative training protocols that pair together different types of sensory stimuli. The results provide solid support for this plasticity being a basis for cross-modal associative memories.

   Reviewed by eLife

2. Cortical plasticity is associated with blood–brain barrier modulation

   This article has 13 authors:

   1. Evyatar Swissa
   2. Uri Monsonego
   3. Lynn T Yang
   4. Lior Schori
   5. Lyna Kamintsky
   6. Sheida Mirloo
   7. Itamar Burger
   8. Sarit Uzzan
   9. Rishi Patel
   10. Peter H Sudmant
   11. Ofer Prager
   12. Daniela Kaufer
   13. Alon Friedman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study builds upon previous work which demonstrated that brain injury results in the entry of a protein called albumin into the brain which then causes diverse effects. The present study shows that prolonged stimulation of a forelimb in a rat leads to albumin entry, and is associated with effects that suggest plasticity is enhanced in the stimulated side of the brain. The strength of evidence was convincing and results are important because they suggest a previously-considered pathological process may be relevant to the normal brain and have benefits.

   Reviewed by eLife

3. Vglut2-based glutamatergic signaling in central noradrenergic neurons is dispensable for normal breathing and chemosensory reflexes

   This article has 5 authors:

   1. Yuan Chang
   2. Savannah Lusk
   3. Andersen Chang
   4. Christopher S Ward
   5. Russell S Ray

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Chang et al. provide glutamate co-expression profiles in the central noradrenergic system and test the requirement of Vglut2-based glutamatergic release in respiratory and metabolic activity under physiologically relevant gas challenges. Their experiments provide compelling evidence that conditional deletion of vesicular glutamate transporters from noradrenergic neurons does not impact steady-state breathing or metabolic activity in room air, hypercapnia, or hypoxia. This study provides an important contribution to our understanding of how noradrenergic neurons regulate respiratory homeostasis in conscious adult mice.

   Reviewed by eLife

4. Statistical examination of shared loci in neuropsychiatric diseases using genome-wide association study summary statistics

   This article has 8 authors:

   1. Thomas P Spargo
   2. Lachlan Gilchrist
   3. Guy P Hunt
   4. Richard JB Dobson
   5. Petroula Proitsi
   6. Ammar Al-Chalabi
   7. Oliver Pain
   8. Alfredo Iacoangeli

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper presents a valuable pipeline based on state-of-the-art analytical software that was used to study genetic pleiotropy between neuropsychiatric disorders. The presented evidence supporting the claims is convincing and now includes an appropriate comparison to previously published methods as well as a detailed exploration of the findings. The created pipeline can thus be used by researchers from diverse fields to study different combinations of diseases and traits.

   Reviewed by eLife

5. Heterogeneity of radial spokes structural components and associated enzymes in Tetrahymena cilia

   This article has 10 authors:

   1. Marta Bicka
   2. Corbin Black
   3. Avrin Ghanaeian
   4. Ewa Joachimiak
   5. Anna Osinka
   6. Sumita Majhi
   7. Anna Konopka
   8. Ewa Bulska
   9. Khanh Huy Bui
   10. Dorota Wloga

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents valuable new insights from the protist Tetrahymena regarding radial spokes, conserved protein complexes that are relevant for cilia motility. The work employs interdisciplinary approaches to provide convincing support for radial spoke composition with some experiments, but there are weaker areas with partially incomplete support, such as relying on knockouts alone rather than including localization studies of tagged proteins.

   Reviewed by eLife

6. Oxygen isotopes in orangutan teeth reveal recent and ancient climate variation

   This article has 12 authors:

   1. Tanya M Smith
   2. Manish Arora
   3. Christine Austin
   4. Janaína Nunes Ávila
   5. Mathieu Duval
   6. Tze Tshen Lim
   7. Philip J Piper
   8. Petra Vaiglova
   9. John de Vos
   10. Ian S Williams
   11. Jian-xin Zhao
   12. Daniel R Green

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study presents convincing evidence for the use of orangutan teeth as terrestrial proxies to reconstruct rainfall regimes, while exploring the potentially conflicting impact of breastfeeding signals. The findings will be of broad interest for those using and developing methods and tools to reconstruct environmental conditions in the historical and archaeological past.

   Reviewed by eLife

7. The genetic and dietary landscape of the muscle insulin signalling network

   This article has 10 authors:

   1. Julian van Gerwen
   2. Stewart WC Masson
   3. Harry B Cutler
   4. Alexis Diaz Vegas
   5. Meg Potter
   6. Jacqueline Stöckli
   7. Søren Madsen
   8. Marin E Nelson
   9. Sean J Humphrey
   10. David E James

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study provides a unique tool for assessing the range of phosphorylation in insulin reactions due to genetic variation and dietary influence through the utilization of genetically distinct mouse strains. The discoveries of this study hold substantial importance, as they shed light on the interplay between genetic attributes and environmental conditions in shaping the insulin-signaling network within skeletal muscle, a crucial regulator of metabolism. The supporting evidence presented is compelling, and the work is anticipated to captivate a wide audience within the metabolism discipline due to its extensive appeal and by providing inspiration for further hypothesis-driven research.

   Reviewed by eLife

8. A reservoir of timescales emerges in recurrent circuits with heterogeneous neural assemblies

   This article has 3 authors:

   1. Merav Stern
   2. Nicolae Istrate
   3. Luca Mazzucato

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental work uses computational network models to suggest a possible origin of the wide range of time scales observed in cortical activity. This claim is supported by convincing evidence based on comparisons between mathematical theory, simulations of spiking network models, and analysis of recordings from the orbitofrontal cortex. This manuscript will be of interest to the broad community of systems and computational neuroscience.

   Reviewed by eLife

9. Modulation of protein-DNA binding reveals mechanisms of spatiotemporal gene control in early Drosophila embryos

   This article has 3 authors:

   1. Sahla Syed
   2. Yifei Duan
   3. Bomyi Lim

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable work explores how transcription factors regulate transcription through cooperative binding to enhancers. Through experiments and modeling, the authors show convincingly that the cooperativity of transcription factor binding regulates transcriptional bursting and the extent of the amount of time that the target promoter remains in an active state.

   Reviewed by eLife

10. Interpersonal alignment of neural evidence accumulation to social exchange of confidence

    This article has 4 authors:

    1. Jamal Esmaily
    2. Sajjad Zabbah
    3. Reza Ebrahimpour
    4. Bahador Bahrami

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      In this important study, Esmaily and colleagues investigate the "confidence matching" between two agents and present a useful exploration of its computational and physiological correlates. Further analyses would be helpful to provide a tighter link between fluctuations of confidence, pupil size, EEG response, and computational variables, to delineate the causal relations between these quantities, which are nevertheless incompletely documented at present.

    Reviewed by eLife