eLife

Latest preprint reviews

1. ER-to-lysosome Ca2+ refilling followed by K+ efflux-coupled store-operated Ca2+ entry in inflammasome activation and metabolic inflammation

   This article has 6 authors:

   1. Hyereen Kang
   2. Seong Woo Choi
   3. Joo Young Kim
   4. Soo-Jin Oh
   5. Sung Joon Kim
   6. Myung-Shik Lee

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This useful study proposes a role of lysosomal Ca2+ release in inflammasome signaling and metabolic inflammation. While the proposed model would be of considerable interest to the field of immunology if validated, the experimental approaches to study calcium dynamics are problematic, with one of several concerns being the transfection efficiency. The major claims of the paper are thus only incompletely supported.

   Reviewed by eLife

2. Spectrally and temporally resolved estimation of neural signal diversity

   This article has 8 authors:

   1. Pedro A.M. Mediano
   2. Fernando E. Rosas
   3. Andrea I. Luppi
   4. Valdas Noreika
   5. Anil K. Seth
   6. Robin L. Carhart-Harris
   7. Lionel Barnett
   8. Daniel Bor

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper describes a new complexity estimator for time series based on state-space modeling, which can directly decompose signal entropy in both time and frequency. The authors compare their estimator to Lempel-Ziv (LZ) complexity using a variety of time series neurophysiological data from humans and non-human primates. This represents a potentially valuable methodological contribution for existing studies using LZ complexity in their analyses, although the paper currently ignores much of the existing literature which has already developed related solutions to the same issues. The strength of the evidence supporting the superiority of the new complexity metric is currently incomplete, and should be backed by additional analyses.

   Reviewed by eLife

3. Molecular classification and tumor microenvironment characteristics in pheochromocytomas

   This article has 13 authors:

   1. Sen Qin
   2. Yawei Xu
   3. Shimiao Yu
   4. Wencong Han
   5. Shiheng Fan
   6. Wenxiang Ai
   7. Kenan Zhang
   8. Yizhou Wang
   9. Xuehong Zhou
   10. Qi Shen
   11. Kan Gong
   12. Luyang Sun
   13. Zheng Zhang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study advances our understanding of the potential therapeutic strategies for the treatment of pheochromocytomas using single-cell transcriptomics. The authors propose a new molecular classification criterion based on the characterization of tumor microenvironmental features, based on solid evidence. The work, which could be improved further through delineating the choice of the PASS scoring system, will be of broad interest to clinicians, medical researchers, and scientists working in the field of pheochromocytoma.

   Reviewed by eLife

4. Gradient organisation of functional connectivity within resting state networks is present from 25 weeks gestation in the human fetal brain

   This article has 15 authors:

   1. Jucha Willers Moore
   2. Siân Wilson
   3. Marianne Oldehinkel
   4. Lucilio Cordero-Grande
   5. Alena Uus
   6. Vanessa Kyriakopoulou
   7. Eugene P Duff
   8. Jonathan O’Muircheartaigh
   9. Mary A Rutherford
   10. Laura C Andreae
   11. Joseph V Hajnal
   12. A David Edwards
   13. Christian F Beckmann
   14. Tomoki Arichi
   15. Vyacheslav R Karolis

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents important findings indicating that gradients of functional connectivity are present in the human foetal brain, and that these gradients develop further during gestation, particularly in multisensory brain regions. The study uses state-of-the-art connectomic mapping techniques. However, recent findings suggest that such gradients may reflect confounds within the analysis technique more than underlying brain functions. The evidence for the authors' claims therefore currently appears inadequate as it does not account for these potential confounds.

   Reviewed by eLife

5. C9orf72 polyPR directly binds to various nuclear transport components

   This article has 3 authors:

   1. Hamidreza Jafarinia
   2. Erik van der Giessen
   3. Patrick R Onck

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides an important starting point for unraveling the molecular basis of the pathological phenotypes of the repeat expansion in the gene associated with open reading frame 72 in human chromosome 9. The coarse-grained simulation method used by the authors goes beyond the state of the art, investigating a compelling number of binding partners. The evidence supporting the claims of the authors is solid, although experimental validation of the results would strengthen the major conclusions of the work. The work will be of broad interest to biophysicists and biochemists.

   Reviewed by eLife

6. Attention modulates human visual responses to objects by tuning sharpening

   This article has 4 authors:

   1. Narges Doostani
   2. Gholam-Ali Hossein-Zadeh
   3. Radoslaw M Cichy
   4. Maryam Vaziri-Pashkam

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study has the potential to shed mechanistic light on how attention mechanisms that influence competition between multiple visual stimuli are modulated by the relative neural similarity of these stimuli. The study provides convincing data that will also be used for future modeling efforts. The study will be of interest to researchers working on the neural basis of visual attention.

   Reviewed by eLife

7. Asymmetric distribution of color-opponent response types across mouse visual cortex supports superior color vision in the sky

   This article has 7 authors:

   1. Katrin Franke
   2. Chenchen Cai
   3. Kayla Ponder
   4. Jiakun Fu
   5. Sacha Sokoloski
   6. Philipp Berens
   7. Andreas Savas Tolias

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Franke et al. explore and characterize color response properties of neurons in mouse primary visual cortex (V1), revealing specific color opponent encoding strategies across the visual field. The paper provides evidence for the existence of color opponency in a subset of neurons within V1 and shows that these color opponent neurons are more numerous in the upper visual field. Support for the main conclusions is convincing and the dataset that forms the basis of the paper is impressive. The paper will make an important contribution to understanding how color is coded in mouse V1.

   Reviewed by eLife

8. Semaphorin7A patterns neural circuitry in the lateral line of the zebrafish

   This article has 6 authors:

   1. Agnik Dasgupta
   2. Caleb C Reagor
   3. Sang Peter Paik
   4. Lauren M Snow
   5. Adrian Jacobo
   6. AJ Hudspeth

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The valuable findings by Dasgupta et al demonstrate the role of Sema7a in fine tuning the morphology of the microcircuit between afferent axons and sensory hair cells in the lateral line organ. The loss and gain of function evidence provides solid support for a role for Sema7a in this process. Additional work is needed to determine the role for different isoforms in Sema7a-mediated synapse formation and chemoattraction as well as cell type specificity.

   Reviewed by eLife

9. Large-scale characterization of cocaine addiction-like behaviors reveals that escalation of intake, aversion-resistant responding, and breaking-points are highly correlated measures of the same construct

   This article has 38 authors:

   1. Giordano de Guglielmo
   2. Lieselot Carrette
   3. Marsida Kallupi
   4. Molly Brennan
   5. Brent Boomhower
   6. Lisa Maturin
   7. Dana Conlisk
   8. Sharona Sedighim
   9. Lani Tieu
   10. McKenzie J Fannon
   11. Angelica R Martinez
   12. Nathan Velarde
   13. Dyar Othman
   14. Benjamin Sichel
   15. Jarryd Ramborger
   16. Justin Lau
   17. Jenni Kononoff
   18. Adam Kimbrough
   19. Sierra Simpson
   20. Lauren C Smith
   21. Kokila Shankar
   22. Selene Bonnet-Zahedi
   23. Elizabeth A Sneddon
   24. Alicia Avelar
   25. Sonja Lorean Plasil
   26. Joseph Mosquera
   27. Caitlin Crook
   28. Lucas Chun
   29. Ashley Vang
   30. Kristel K Milan
   31. Paul Schweitzer
   32. Bonnie Lin
   33. Beverly Peng
   34. Apurva S Chitre
   35. Oksana Polesskaya
   36. Leah C Solberg Woods
   37. Abraham A Palmer
   38. Olivier George

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript tackles a significant problem in addiction science: how interdependent are measures of "addiction-like" behavioral phenotypes? The manuscript provides compelling evidence that, under these experimental conditions, escalation of intake, punishment-resistant responding, and progressive ratio break points reflect a single underlying construct rather than reflect distinct unrelated measures. The exceptionally large sample size and incorporation of multiple behavioral endpoints add strength to this paper, and make it an important resource for the field.

   Reviewed by eLife

10. RETRACTED: PAK3 downregulation induces cognitive impairment following cranial irradiation

    This article has 4 authors:

    1. Haksoo Lee
    2. Hyunkoo Kang
    3. Changjong Moon
    4. BuHyun Youn

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      The study investigates the functional impact of cranial irradiation in mouse and proposes PAK3 as molecular element involved in radiation-induced cognitive decrement. The significance of the findings is useful for fields covering radiation, brain tumor and cognition. The strength of evidence is solid, although the referees expressed divergent views on the manuscript.

    Reviewed by eLife