eLife

Latest preprint reviews

1. Genetic screen identified PRMT5 as a neuroprotection target against cerebral ischemia

   This article has 9 authors:

   1. Haoyang Wu
   2. Peiyuan Lv
   3. Jinyu Wang
   4. Brian Bennett
   5. Jiajia Wang
   6. Pishun Li
   7. Yi Peng
   8. Guang Hu
   9. Jiaji Lin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors performed a useful RNAi screen to identify epigenetic regulators involved in oxygen-glucose deprivation (OGD)-induced neuronal injury. PRMT5 was identified as a negative regulator of neuronal cell survival after OGD. Solid in vitro and in vivo data suggest that PRMT5 could be a novel therapeutic target for the treatment of ischemic stroke.

   Reviewed by eLife

2. DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response

   This article has 34 authors:

   1. Ernie Yulyaningsih
   2. Jung H Suh
   3. Melania Fanok
   4. Roni Chau
   5. Hilda Solanoy
   6. Ryan Takahashi
   7. Anna I Bakardjiev
   8. Isabel Becerra
   9. N Butch Benitez
   10. Chi-Lu Chiu
   11. Sonnet S Davis
   12. William E Dowdle
   13. Timothy Earr
   14. Anthony A Estrada
   15. Audrey Gill
   16. Connie Ha
   17. Patrick CG Haddick
   18. Kirk R Henne
   19. Martin Larhammar
   20. Amy W-S Leung
   21. Romeo Maciuca
   22. Bahram Memarzadeh
   23. Hoang N Nguyen
   24. Alicia A Nugent
   25. Maksim Osipov
   26. Yingqing Ran
   27. Kevin Rebadulla
   28. Elysia Roche
   29. Thomas Sandmann
   30. Jing Wang
   31. Joseph W Lewcock
   32. Kimberly Scearce-Levie
   33. Lesley A Kane
   34. Pascal E Sanchez

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents solid evidence to support the effectiveness of the novel eIF2B activator DNL343 in mitigating the integrated stress response (ISR) and reducing neurodegeneration associated with ISR activation in two mouse models. These important findings offer promise for the potential use of DNL343 in treating vanishing white matter disease (VWMD), a rare condition resulting from eIF2B loss of function, and in addressing other neurodegenerative disorders characterized by ISR involvement. The study also identified potential VWMD biomarkers, which hold significance for assessing disease progression and evaluating treatment responses.

   Reviewed by eLife

3. Four individually identified paired dopamine neurons signal taste punishment in larval Drosophila

   This article has 5 authors:

   1. Denise Weber
   2. Katrin Vogt
   3. Anton Miroschnikow
   4. Michael J Pankratz
   5. Andreas S Thum

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This comprehensive study presents important findings that delineate how specific dopaminergic neurons (DANs) instruct aversive learning in Drosophila larvae exposed to high salt through an integration of behavioral experiments, imaging, and connectomic analysis. The work reveals how a numerically minimal circuit achieves remarkable functional complexity, with redundancies and synergies within the DL1 cluster that challenge our understanding of how few neurons generate learning behaviors. By establishing a framework for sensory-driven learning pathways, the study makes a compelling and substantial contribution to understanding associative conditioning while demonstrating conservation of learning mechanisms across Drosophila developmental stages.

   Reviewed by eLife

4. Neuron-specific RNA-sequencing reveals different responses in peripheral neurons after nerve injury

   This article has 5 authors:

   1. Sara Bolívar
   2. Elisenda Sanz
   3. David Ovelleiro
   4. Douglas W Zochodne
   5. Esther Udina

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The valuable findings in this study show that subpopulations of peripheral sensory neurons display different capacities for regeneration after a similar injury. Nociceptor neurons have greater regeneration over mechanoreceptor, proprioceptors and motor neurons. This differential responsiveness of neuronal subtypes was traced to activation of different transcriptional programs, which were carefully analyzed and quantitated, resulting in solid evidence for the conclusions.

   Reviewed by eLife

5. Prior probability cues bias sensory encoding with increasing task exposure

   This article has 5 authors:

   1. Kevin Walsh
   2. David P McGovern
   3. Jessica Dully
   4. Simon P Kelly
   5. Redmond G O'Connell

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important paper sheds light on the role of expectations in perceptual decision-making. Sophisticated analyses of human EEG data provide convincing evidence that both motor preparation and sensory processing were affected by expectations, albeit with different time courses. These findings will be of interest to scientists interested in perception and decision-making.

   Reviewed by eLife

6. Separating the control of moving and holding in human post-stroke arm paresis

   This article has 6 authors:

   1. Alkis M Hadjiosif
   2. Kahori Kita
   3. Scott T Albert
   4. Robert A Scheidt
   5. Reza Shadmehr
   6. John W Krakauer

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study extends the previous interesting work of this group to address the potentially different control of movement and posture. Through experiments in which stroke participants used a robotic manipulandum, the authors provide solid evidence supporting a lack of a relation between the resting force postural bias they measure (closely related to the flexor synergy in stroke) and kinematic deficits during movement. Based on these results, the authors propose a conceptual framework that differentially weights the two main descending pathways (corticospinal tract and reticulospinal tract) for neurologically intact and stroke patients.

   Reviewed by eLife

7. Regulation of phage lambda packaging motor-DNA interactions: Nucleotide independent and dependent gripping and friction

   This article has 7 authors:

   1. Brandon Rawson
   2. Mariam Ordyan
   3. Qin Yang
   4. Jean Sippy
   5. Michael Feiss
   6. Carlos E. Catalano
   7. Douglas E. Smith

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study has major implications that can be paradigm-shifting for our understanding of how the phage lambda DNA motor works and what the precise roles of the TerS and TerL proteins in the motor complex are. The experiments are exceptionally well done, providing compelling evidence for the conclusion of the authors.

   Reviewed by eLife

8. Class A scavenger receptor MARCO negatively regulates Ace expression and aldosterone production

   This article has 7 authors:

   1. Conan JO O'Brien
   2. Giorgio Ratti
   3. Hellen Veida-Silva
   4. Emma Haberman
   5. Charles Sweeney
   6. Siamon Gordon
   7. Ana I Domingos

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     O'Brien and co-authors provide important data demonstrating that tissue-resident macrophages can exert physiological functions and influence endocrine systems.Their model in which AMs negatively regulate aldosterone production via effects exerted in the lung is solid. The work will be of broad interest to cell biologists and immunologists.

   Reviewed by eLife

9. Neural network emulation of the human ventricular cardiomyocyte action potential for more efficient computations in pharmacological studies

   This article has 10 authors:

   1. Thomas Grandits
   2. Christoph M Augustin
   3. Gundolf Haase
   4. Norbert Jost
   5. Gary R Mirams
   6. Steven A Niederer
   7. Gernot Plank
   8. András Varró
   9. László Virág
   10. Alexander Jung

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable prospective study develops a new tool to accelerate pharmacological studies by using neural networks to emulate the human ventricular cardiomyocyte action potential. The evidence supporting the conclusions is convincing, based on using a large and high-quality dataset to train the neural network emulator. There are nevertheless a few areas in which the article may be improved through validating the neural network emulators against extensive experimental data. In addition, the article may be improved through delineating the exact speed-up achieved and the scope for acceleration. The work will be of broad interest to scientists working in cardiac simulation and quantitative system pharmacology.

   Reviewed by eLife

10. A robust method for measuring aminoacylation through tRNA-Seq

    This article has 2 authors:

    1. Kristian Davidsen
    2. Lucas B Sullivan

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This valuable paper presents a new protocol for quantifying tRNA aminoacylation levels by deep sequencing. The improved methods for discrimination of aminoacyl-tRNAs from non-acylated tRNAs, more efficient splint-assisted ligation to modify the tRNAs' ends for the following RT-PCR reaction, along with the use of an error-tolerating mapping algorithm to map the tRNA sequencing reads provide new tools for anyone interested in tRNA concentrations and functional states in different cells and organisms. The results and conclusions are solid, with well-designed tests to optimize the protocol under different conditions.

    Reviewed by eLife