eLife

Latest preprint reviews

1. Optogenetic activation of visual thalamus generates artificial visual percepts

   This article has 9 authors:

   1. Jing Wang
   2. Hamid Azimi
   3. Yilei Zhao
   4. Melanie Kaeser
   5. Pilar Vaca Sánchez
   6. Abraham Vazquez-Guardado
   7. John A Rogers
   8. Michael Harvey
   9. Gregor Rainer

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study shows that tree shrews can detect optogenetic stimulation of the lateral geniculate nucleus (LGN) after training detection of visual stimuli. The solid evidence links optogenetic stimulation of the LGN to behavioural detection and neurophysiological responses. This paper is potentially of interest to neuroscientists and clinicians working on the visual system and visual prostheses.

   Reviewed by eLife

2. MEMO1 binds iron and modulates iron homeostasis in cancer cells

   This article has 14 authors:

   1. Natalia Dolgova
   2. Eva-Maria E Uhlemann
   3. Michal T Boniecki
   4. Frederick S Vizeacoumar
   5. Anjuman Ara
   6. Paria Nouri
   7. Martina Ralle
   8. Marco Tonelli
   9. Syed A Abbas
   10. Jaala Patry
   11. Hussain Elhasasna
   12. Andrew Freywald
   13. Franco J Vizeacoumar
   14. Oleg Y Dmitriev

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Dolgova et al present a well-written and important manuscript focused on the mechanism of MEMO1 function in tumor cells. The authors explore whether the mechanism of MEMO1 overexpression in breast cancer, especially TNBC, is related to regulating iron given evidence that MEMO1 binds multiple proteins in the iron regulation pathway. While the data is in part compelling, the claims are based on indirect evidence for a central role of MEMO1 in tumorogenesis and perhaps metastasis via its effect on iron homeostasis.

   Reviewed by eLife

3. Neutrophils actively swell to potentiate rapid migration

   This article has 3 authors:

   1. Tamas L Nagy
   2. Evelyn Strickland
   3. Orion D Weiner

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study significantly advances our understanding of the role of water influx and swelling on neutrophil migration in response to chemoattractant. The evidence supporting the conclusions, based on a genome-wide CRISPR screen and high quality cellular observations, is compelling. This paper will be of interest to cell biologists and biophysicists working on cell migration.

   Reviewed by eLife

4. MDverse, shedding light on the dark matter of molecular dynamics simulations

   This article has 12 authors:

   1. Johanna KS Tiemann
   2. Magdalena Szczuka
   3. Lisa Bouarroudj
   4. Mohamed Oussaren
   5. Steven Garcia
   6. Rebecca J Howard
   7. Lucie Delemotte
   8. Erik Lindahl
   9. Marc Baaden
   10. Kresten Lindorff-Larsen
   11. Matthieu Chavent
   12. Pierre Poulain

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The study presents a valuable tool for searching molecular dynamics simulation data, making such datasets accessible for open science. The authors provide convincing evidence that it is possible to identify noteworthy molecular dynamics simulation datasets and that their analysis can produce information of value to the community.

   Reviewed by eLife

5. Heat stress impairs centromere structure and segregation of meiotic chromosomes in Arabidopsis

   This article has 7 authors:

   1. Lucie Crhak Khaitova
   2. Pavlina Mikulkova
   3. Jana Pecinkova
   4. Manikandan Kalidass
   5. Stefan Heckmann
   6. Inna Lermontova
   7. Karel Riha

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study is an important contribution to our insights into the impact of heat stress on sexual reproduction in plants and provides information about how centromere integrity is affected by heat stress during male meiosis in Arabidopsis thaliana. The evidence supporting the claims, specifically the dynamics of tagged proteins in meiocytes by live cell imaging is solid, even though a deeper mechanistic understanding is still lacking.

   Reviewed by eLife

6. Control of meiotic entry by dual inhibition of a key mitotic transcription factor

   This article has 3 authors:

   1. Amanda J Su
   2. Siri C Yendluri
   3. Elçin Ünal

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study highlights several important regulatory pathways that contribute to the control of entry into meiosis by turning down mitotic functions. Central to this regulation is the control of Swi4 level and activity, and convincing overexpression experiments identify downstream effectors of Swi4.

   Reviewed by eLife

7. Regulation of multiple signaling pathways promotes the consistent expansion of human pancreatic progenitors in defined conditions

   This article has 12 authors:

   1. Luka Jarc
   2. Manuj Bandral
   3. Elisa Zanfrini
   4. Mathias Lesche
   5. Vida Kufrin
   6. Raquel Sendra
   7. Daniela Pezzolla
   8. Ioannis Giannios
   9. Shahryar Khattak
   10. Katrin Neumann
   11. Barbara Ludwig
   12. Anthony Gavalas

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study describes a method to decouple the mechanisms supporting pancreatic progenitor self-renewal and expansion from feed-forward mechanisms promoting their differentiation allowing in vitro expansion of hPSC-derived pancreatic progenitors. The strength of evidence is convincing in that the authors use appropriate and validated methodology in line with current state-of-the-art. The work will be of interest to the field of beta cell replacement therapy in diabetes.

   Reviewed by eLife

8. Nitric oxide feedback to ciliary photoreceptor cells gates a UV avoidance circuit

   This article has 7 authors:

   1. Kei Jokura
   2. Nobuo Ueda
   3. Martin Gühmann
   4. Luis Alfonso Yañez-Guerra
   5. Piotr Słowiński
   6. Kyle C. A. Wedgwood
   7. Gáspár Jékely

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study reports the discovery of a new circuit mechanism for light-avoidance behavior in the marine annelid, Platynereis dumerilii. Using calcium imaging, molecular perturbations, behavioral measurements, and modeling, the authors provide compelling evidence that nitric oxide is released by postsynaptic neurons onto ciliary photoreceptors to prolong and enhance their response to ultraviolet light. The fundamental new role of nitric oxide described in this study may be conserved across animal phyla and thus will be of broad interests to neuroscientists and neuroendocrinologists.

   Reviewed by eLife

9. The information bottleneck as a principle underlying multi-area cortical representations during decision-making

   This article has 10 authors:

   1. Michael Kleinman
   2. Tian Wang
   3. Derek Xiao
   4. Ebrahim Feghhi
   5. Kenji Lee
   6. Nicole Carr
   7. Yuke Li
   8. Nima Hadidi
   9. Chandramouli Chandrasekaran
   10. Jonathan C Kao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript reports a useful computational study of information encoding across the monkey prefrontal and pre-motor cortices during decision making. While many of the conclusions are supported with solid analyses, the evidence for the main interpretation of the results, the role of an information bottleneck across areas, is not complete. The results will be of interest to a systems and computational neuroscience audience.

   Reviewed by eLife

10. Loss of tumor suppressor TMEM127 drives RET-mediated transformation through disrupted membrane dynamics

    This article has 13 authors:

    1. Timothy J Walker
    2. Eduardo Reyes-Alvarez
    3. Brandy D Hyndman
    4. Michael G Sugiyama
    5. Larissa CB Oliveira
    6. Aisha N Rekab
    7. Mathieu JF Crupi
    8. Rebecca Cabral-Dias
    9. Qianjin Guo
    10. Patricia LM Dahia
    11. Douglas S Richardson
    12. Costin N Antonescu
    13. Lois M Mulligan

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This valuable paper provides convincing evidence that loss of the tumor suppressor TMEM127 causes disorganization of plasma membrane lipid domains, alters clathrin assembly, and inhibits endocytosis of a variety of cell surface receptors, leading to increased cell surface levels of signaling proteins including RET and other transmembrane receptor tyrosine kinases. The results are significant for understanding how RET127 loss contributes to pheochromocytoma, although the evidence is indirect owing to the lack of human pheochromocytoma cell lines. The results will be of interest for researchers studying pheochromocytoma and endocytosis mechanisms.

    Reviewed by eLife