eLife

Latest preprint reviews

1. Get the gist of the story: Neural map of topic keywords in multi-speaker environment

   This article has 2 authors:

   1. Hyojin Park
   2. Joachim Gross

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study advances our understanding of how listeners understand speech when there are multiple talkers by showing that the content of the speech affects acoustic processing. The evidence is generally solid, although additional details on the methods to allow replication would strengthen the study. The work will be of use to researchers interested in the neuroscience of speech and language processing.

   Reviewed by eLife

2. Towards a Neurometric-based Construct Validity of Trust

   This article has 5 authors:

   1. Pin-Hao A. Chen
   2. Dominic Fareri
   3. Berna Güroğlu
   4. Mauricio R. Delgado
   5. Luke J. Chang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study identifies a spatial pattern of neural activity that corresponds to trust in an investment game. It provides a compelling assessment of the validity of this pattern by assessing its expression, or lack thereof, in a variety of datasets. This work, and the "neurometrics" approach it proposes, will be of broad interest to psychology researchers more generally.

   Reviewed by eLife

3. Truncated radial glia as a common precursor in the late corticogenesis of gyrencephalic mammals

   This article has 11 authors:

   1. Merve Bilgic
   2. Quan Wu
   3. Taeko Suetsugu
   4. Atsunori Shitamukai
   5. Yuji Tsunekawa
   6. Tomomi Shimogori
   7. Mitsutaka Kadota
   8. Osamu Nishimura
   9. Shigehiro Kuraku
   10. Hiroshi Kiyonari
   11. Fumio Matsuzaki

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important study that improves gene models for the ferret genome and identifies neural progenitors that are comparable to those found in developing human brains. The data are convincing and clearly presented. Of particular interest to the field, the work identifies enriched expression of FOXJ1 in late truncated radial glia, strongly indicating that towards the end of neurogenesis, these cells likely give rise to ependymal cells. The work is of interest to anyone studying the development of the nervous system, especially colleagues studying the evolution of development.

   Reviewed by eLife, Review Commons

4. An in silico testbed for fast and accurate MR labeling of orthopedic implants

   This article has 10 authors:

   1. Gregory M Noetscher
   2. Peter J Serano
   3. Marc Horner
   4. Alexander Prokop
   5. Jonathan Hanson
   6. Kyoko Fujimoto
   7. James Brown
   8. Ara Nazarian
   9. Jerome Ackerman
   10. Sergey N Makaroff

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript will provide a valuable method to evaluate the safety of MR in patients with orthopaedic implants, which is required in clinics. A strength of the work is that the in-silicon testbed is solid, based on the widely available human project, and validated. In addition, the toolbox will be open for clinical practice.

   Reviewed by eLife

5. Txnip deletions and missense alleles prolong the survival of cones in a retinitis pigmentosa mouse model

   This article has 3 authors:

   1. Yunlu Xue
   2. Yimin Zhou
   3. Constance L Cepko

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study advances our understanding of the cell specific treatment of cone photoreceptor degeneration by Txnip. The evidence supporting the conclusions is compelling with rigorous genetic manipulation of Txnip mutations. The work will be of broad interest to vision researchers, cell biologists and biochemists.

   Reviewed by eLife

6. BRAIDing receptors for cell-specific targeting

   This article has 12 authors:

   1. Hui Chen
   2. Sung-Jin Lee
   3. Ryan Li
   4. Asmiti Sura
   5. Nicholas Suen
   6. Archana Dilip
   7. Yan Pomogov
   8. Meghah Vuppalapaty
   9. Timothy T Suen
   10. Chenggang Lu
   11. Yorick Post
   12. Yang Li

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study presents a new way to selectively activate a cell signaling pathway in a specific cell type by designer ligands that link signaling co-receptors to a marker specific to the target cells. Convincing experimental results demonstrate that the agonist molecules activate Wnt signaling in target cells expressing the marker as intended. More broadly, this concept could be used to induce Wnt signaling or another pathway initiated by co-receptor association in a cell type-specific manner. In vitro results in this study could be further strengthened by assessing the biological consequences of Wnt activation in target cells.

   Reviewed by eLife

7. Baited reconstruction with 2D template matching for high-resolution structure determination in vitro and in vivo without template bias

   This article has 3 authors:

   1. Bronwyn A Lucas
   2. Benjamin A Himes
   3. Nikolaus Grigorieff

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important demonstration of how the false-positive rate of high-resolution 2D template matching to find particles of a given target structure in 2D cryo-EM images (2DTM) relates to overfitting the data towards the template. The authors present new methods to measure the amount of model bias that gets introduced in high-resolution features of such maps, with compelling evidence that high-resolution features that are not present in the template can still be reconstructed in 3D from images obtained by 2DTM.

   Reviewed by eLife

8. Homeostatic synaptic plasticity of miniature excitatory postsynaptic currents in mouse cortical cultures requires neuronal Rab3a

   This article has 3 authors:

   1. Andrew G Koesters
   2. Mark M Rich
   3. Kathrin Engisch

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study presents findings on the role of the small GTPase Rab3A in homeostatic plasticity. While the study provides solid evidence for a requirement of Rab3A in homeostatic up-scaling in cultured mouse neurons, it does not provide a model of how Rab3A is involved in homeostatic plasticity. The work will be of interest to researchers in the field of synaptic transmission and synaptic plasticity.

   Reviewed by eLife

9. Identification of key yeast species and microbe–microbe interactions impacting larval growth of Drosophila in the wild

   This article has 16 authors:

   1. Ayumi Mure
   2. Yuki Sugiura
   3. Rae Maeda
   4. Kohei Honda
   5. Nozomu Sakurai
   6. Yuuki Takahashi
   7. Masayoshi Watada
   8. Toshihiko Katoh
   9. Aina Gotoh
   10. Yasuhiro Gotoh
   11. Itsuki Taniguchi
   12. Keiji Nakamura
   13. Tetsuya Hayashi
   14. Takane Katayama
   15. Tadashi Uemura
   16. Yukako Hattori

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important study that addresses a significant question in microbiome research. The authors provide convincing evidence that certain bacterial groups within the fly microbiome have critical functions for host development. Additionally, dietary aspects such as microbial community progression in a natural food source are integrated into their host-microbe interaction analyses.

   Reviewed by eLife

10. RNA-binding deficient TDP-43 drives cognitive decline in a mouse model of TDP-43 proteinopathy

    This article has 17 authors:

    1. Julie Necarsulmer
    2. Jeremy Simon
    3. Baggio Evangelista
    4. Youjun Chen
    5. Xu Tian
    6. Sara Nafees
    7. Ariana Marquez Gonzalez
    8. Huijun Jiang
    9. Ping Wang
    10. Deepa Ajit
    11. Viktoriya Nikolova
    12. Kathryn Harper
    13. Jennifer Ezzell
    14. Feng-Chang Lin
    15. Adriana Beltran
    16. Sheryl Moy
    17. Todd Cohen

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      Necarsulmer et al describe an interesting new mouse model of TDP-43 proteinopathy in which gene editing was used to introduce a K145Q acetylation-mimic mutation previously shown to impair RNA-binding capacity and induce downstream misregulation of target genes. Mice homozygous for this mutation are convincingly shown to display cognitive/behavioral impairment, TDP-43 phosphorylation and insolubility, and changes in gene expression and splicing. This novel mouse model replicates some key hallmarks of human frontotemporal lobar degeneration and will be an important contribution to the field.

    Reviewed by eLife