eLife

Latest preprint reviews

1. Heparan sulfate promotes TRAIL-induced tumor cell apoptosis

   This article has 9 authors:

   1. Yin Luo
   2. Huanmeng Hao
   3. Zhangjie Wang
   4. Chih Yean Ong
   5. Robert Dutcher
   6. Yongmei Xu
   7. Jian Liu
   8. Lars C Pedersen
   9. Ding Xu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study advances our understanding of TRAIL-induced apoptosis by defining how Heparan triggers this pathway at the molecular level. The evidence supporting the conclusions is compelling, with rigorous binding assays, structural methods, and cellular studies. The work will be of broad interest to cell biologists and biochemists.

   Reviewed by eLife

2. Arpin deficiency increases actomyosin contractility and vascular permeability

   This article has 12 authors:

   1. Armando Montoya-Garcia
   2. Idaira M Guerrero-Fonseca
   3. Sandra D Chanez-Paredes
   4. Karina B Hernandez-Almaraz
   5. Iliana I Leon-Vega
   6. Angelica Silva-Olivares
   7. Abigail Betanzos
   8. Monica Mondragon-Castelan
   9. Ricardo Mondragon-Flores
   10. Citlaltepetl Salinas-Lara
   11. Hilda Vargas-Robles
   12. Michael Schnoor

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents solid results to demonstrate that arpin is expressed in the endothelium of blood vessels and that its deficiency leads to leaky blood vessels in in vivo and in vitro models. The work does not yet clarify the mechanistic connection between arpin and increased ROCK activity. The study adds some insights to our understanding of the complicated network of proteins that control this process, and it will be useful to individuals within this defined field of study.

   Reviewed by eLife

3. Structure and dynamics of cholesterol-mediated aquaporin-0 arrays and implications for lipid rafts

   This article has 5 authors:

   1. Po-Lin Chiu
   2. Juan D Orjuela
   3. Bert L de Groot
   4. Camilo Aponte Santamaría
   5. Thomas Walz

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript aims to unravel the contribution of cholesterol to aquaporin-0 (AQP0) tetramer array formation within lens membranes. Compelling electron crystallography data are combined with solid molecular dynamics experiments to identify a specific cholesterol binding site of significance to protein clustering within lipid rafts. The important work advances our understanding of membrane biology and will be of broad interest to membrane transport biologists, biochemists, and structural biologists.

   Reviewed by eLife

4. Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevity

   This article has 11 authors:

   1. Zhixin Jing
   2. Phillip Galbo
   3. Luis Ovando
   4. Megan Demouth
   5. Skylar Welte
   6. Rosa Park
   7. Kartik Chandran
   8. Yinghao Wu
   9. Thomas MacCarthy
   10. Deyou Zheng
   11. David Fooksman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Despite the importance of long-lived plasma cells (LLPCs), particularly for the infection and vaccination field, it is still unclear how they acquire their longevity. With a solid genetic approach, the authors demonstrate quite convincingly a requirement for chemokine/chemokine receptor-mediated interaction in LLPC longevity. The data are very valuable for the development of new types of vaccines.

   Reviewed by eLife

5. Transformer-based spatial–temporal detection of apoptotic cell death in live-cell imaging

   This article has 18 authors:

   1. Alain Pulfer
   2. Diego Ulisse Pizzagalli
   3. Paolo Armando Gagliardi
   4. Lucien Hinderling
   5. Paul Lopez
   6. Romaniya Zayats
   7. Pau Carrillo-Barberà
   8. Paola Antonello
   9. Miguel Palomino-Segura
   10. Benjamin Grädel
   11. Mariaclaudia Nicolai
   12. Alessandro Giusti
   13. Marcus Thelen
   14. Luca Maria Gambardella
   15. Thomas T Murooka
   16. Olivier Pertz
   17. Rolf Krause
   18. Santiago Fernandez Gonzalez

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study advances our understanding of spatial-temporal cell dynamics both in vivo and in vitro. The authors provide solid evidence for their innovative deep learning-based apoptosis detection system, ADeS, which utilizes the principle of activity recognition. This work will be of broad interest to cell biologists and neuroscientists.

   Reviewed by eLife

6. ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin

   This article has 21 authors:

   1. Cristina Cacho-Navas
   2. Carmen López-Pujante
   3. Natalia Reglero-Real
   4. Natalia Colás-Algora
   5. Ana Cuervo
   6. Jose Javier Conesa
   7. Susana Barroso
   8. Gema de Rivas
   9. Sergio Ciordia
   10. Alberto Paradela
   11. Gianluca D'Agostino
   12. Carlo Manzo
   13. Jorge Feito
   14. Germán Andrés
   15. Francisca Molina-Jiménez
   16. Pedro Majano
   17. Isabel Correas
   18. José-Maria Carazo
   19. Sussan Nourshargh
   20. Meritxell Huch
   21. Jaime Millán

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors report useful findings on novel function of apical ICAM1 in regulating bile duct homeostasis in the liver. The strength of evidence is solid using appropriate methodolgy with only minor weakness. The findings will be of interest to researchers in hepatology and membrane traffic biology.

   Reviewed by eLife

7. Convergence, plasticity, and tissue residence of regulatory T cell response via TCR repertoire prism

   This article has 8 authors:

   1. Tatyana O Nakonechnaya
   2. Bruno Moltedo
   3. Ekaterina V Putintseva
   4. Sofya Leyn
   5. Dmitry A Bolotin
   6. Olga V Britanova
   7. Mikhail Shugay
   8. Dmitriy M Chudakov

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript presents a valuable approach to exploring CD4+ T-cell response in mice across stimuli and tissues through the analysis of their T-cell receptor repertoires. The authors use a transgenic mouse model with reduced diversity of the T-cell receptor repertoire to elicit more consistent T-cell responses across individuals, demonstrating challenge-specific and tissue-specific responses of regulatory T-cells. The evidence for the authors' conclusions is solid, and the work will be of interest to immunologists studying T cell responses.

   Reviewed by eLife

8. Development and validation of a high throughput screening platform to enable target identification in skeletal muscle cells from Duchenne Muscular Dystrophy (DMD) patients

   This article has 13 authors:

   1. Santosh Hariharan
   2. Oana Lorintiu
   3. Chia-Chin Lee
   4. Eve Duchemin-Pelletier
   5. Xianfeng Li
   6. Aileen Healy
   7. Regis Doyonnas
   8. Luc Selig
   9. Pauline Poydenot
   10. Erwann Ventre
   11. Andrea Weston
   12. Jane Owens
   13. Nicolas Christoforou

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is a solid methods paper developing a machine learning based protocol differentiating normal and diseased myofibers. It emerges with and validates a potentially valuable approach to diifferentiate healthy and Duchenne muscle dystrophy myofibers.

   Reviewed by eLife

9. The CD4 transmembrane GGXXG and juxtamembrane (C/F)CV+C motifs mediate pMHCII-specific signaling independently of CD4-LCK interactions

   This article has 8 authors:

   1. Mark S Lee
   2. Peter J Tuohy
   3. Caleb Y Kim
   4. Philip P Yost
   5. Katrina Lichauco
   6. Heather L Parrish
   7. Koenraad Van Doorslaer
   8. Michael S Kuhns

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides valuable new insights as to how two evolutionary conserved motifs in CD4 contribute to the CD4-mediated enhancement of TCR signaling independently of the CD4-LCK interaction. The data at hand are convincing, even if confined to a cell line model and not substantiated in vivo and with little new mechanistic insight provided regarding the domains of CD4 shown to have significant roles in the signaling process. Without the data from primary cells it is difficult to make statements about the quantitative contribution of LCK-dependent and independent functions of CD4 in TCR signaling.

   Reviewed by eLife

10. Goal-directed vocal planning in a songbird

    This article has 4 authors:

    1. Anja T Zai
    2. Anna E Stepien
    3. Nicolas Giret
    4. Richard HR Hahnloser

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This important work identifies a previously uncharacterized capacity for songbird to recover vocal targets even without sensory experience. The evidence supporting this claim is convincing, with technically difficult and innovative experiments exploring goal-directed vocal plasticity in deafened birds. This work has broad relevance to the fields of vocal and motor learning.

    Reviewed by eLife, PREreview