eLife

Latest preprint reviews

1. Selective consolidation of learning and memory via recall-gated plasticity

   This article has 2 authors:

   1. Jack W Lindsey
   2. Ashok Litwin-Kumar

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental work proposes a novel mechanism for memory consolidation where short-term memory provides a gating signal for memories to be consolidated into long-term storage. The work combines extensive analytical and numerical work applied to three different scenarios and provides a convincing analysis of the benefits of the proposed model, although some of the analyses are limited to the type of memory consolidation the authors consider (and don't consider), which limits the impact. The work will be of interest to neuroscientists and many other researchers interested in the mechanistic underpinnings of memory.

   Reviewed by eLife

2. Defective mesenchymal Bmpr1a-mediated BMP signaling causes congenital pulmonary cysts

   This article has 11 authors:

   1. Yongfeng Luo
   2. Ke Cao
   3. Joanne Chiu
   4. Hui Chen
   5. Hong-Jun Wang
   6. Matthew E Thornton
   7. Brendan H Grubbs
   8. Martin Kolb
   9. Michael S Parmacek
   10. Yuji Mishina
   11. Wei Shi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable paper characterizes a murine model for congenital cystic airway abnormalities (CPAM). In contrast to previous assumptions that only epithelial cells are involved in the formation of pulmonary cysts, the authors provide compelling new evidence that defective BMP signaling in lung mesenchymal cells can disrupt airway development. Knowing that proper BMP signaling in mesenchymal cells is required for normal cyst-free lungs could potentially pave the way to understanding and preventing CPAM in infants at risk for this common disorder, which can be fatal if untreated. The relevance of the murine model could be enhanced by further molecular and histological comparison with human cysts.

   Reviewed by eLife

3. Uncharacterized yeast gene YBR238C, an effector of TORC1 signaling in a mitochondrial feedback loop, accelerates cellular aging via HAP4- and RMD9-dependent mechanisms

   This article has 10 authors:

   1. Mohammad Alfatah
   2. Jolyn Jia Jia Lim
   3. Yizhong Zhang
   4. Arshia Naaz
   5. Trishia Yi Ning Cheng
   6. Sonia Yogasundaram
   7. Nashrul Afiq Faidzinn
   8. Jovian Jing Lin
   9. Birgit Eisenhaber
   10. Frank Eisenhaber

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study identifies an uncharacterized yeast gene regulating chronological lifespan in a mitochondrial-dependent pathway. The approach to identify and characterise this new gene is appealing, but the evidence in support of some of the major conclusions is incomplete. The paper focuses on chronological lifespan and mitochondrial function, and it will be of interest to yeast biologists working in metabolism and aging.

   Reviewed by eLife

4. Heat Shock Factor 1 forms nuclear condensates and restructures the yeast genome before activating target genes

   This article has 3 authors:

   1. Linda S Rubio
   2. Suman Mohajan
   3. David S Gross

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is a valuable contribution to our understanding of how different cell stressors (ethanol or heat-shock) elicit unique responses at the genomic and topographical level under the regulation of yeast transcription factor Hsf1, providing solid evidence documenting the temporal coupling (or lack thereof) between Hsf1 aggregation and long-range communication among co-regulated heat-shock loci versus chromatin remodeling and transcriptional activation. A particular strength is the combination of genomic and imaging-based experimental approaches applied to genetically engineered in vivo systems.

   Reviewed by eLife

5. Caveolin-1 protects endothelial cells from extensive expansion of transcellular tunnel by stiffening the plasma membrane

   This article has 18 authors:

   1. Camille Morel
   2. Eline Lemerle
   3. Feng-Ching Tsai
   4. Thomas Obadia
   5. Nishit Srivastava
   6. Maud Marechal
   7. Audrey Salles
   8. Marvin Albert
   9. Caroline Stefani
   10. Yvonne Benito
   11. François Vandenesch
   12. Christophe Lamaze
   13. Stéphane Vassilopoulos
   14. Matthieu Piel
   15. Patricia Bassereau
   16. David Gonzalez-Rodriguez
   17. Cecile Leduc
   18. Emmanuel Lemichez

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study identifies the role of Caveolin1 and Cavin1 as regulators of TransEndothelial Macroaperture (TEM). The methodology used is rigorous and compelling, and further research can point to more mechanistic understanding of the process.

   Reviewed by eLife

6. The title and authors for this article are not available from our external data provider yet:
   10.31219/osf.io/preprints/psyarxiv/r49sy

7. Identification of CFAP52 as a novel diagnostic target of male infertility with defects of sperm head-tail connection and flagella development

   This article has 7 authors:

   1. Hui-Juan Jin
   2. Tiechao Ruan
   3. Siyu Dai
   4. Xin-Yan Geng
   5. Yihong Yang
   6. Ying Shen
   7. Su-Ren Chen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides useful information on the function of a ciliary and flagellar-associated protein, CFAP52, in the assembly of sperm head-tail connecting apparatus (HTCA) and tail formation in humans and mice. The significance is to identify CFAP52 as a genetic factor for asthenoteratozoospermia with a mixed acephalic spermatozoa syndrome (ASS) and multiple morphological abnormalities of the sperm flagella (MMAF) phenotype. The strength of the study is that the experimental evidence using CFAP52 loss-of-function in mice is solid to support that CFAP52 is essential for sperm motility and male fertility by contributing to HTCA and 9+2 axoneme, corroborating the sperm phenotypes of human patients with compound heterozygous mutations in CFAP52.

   Reviewed by eLife

8. The embryonic role of juvenile hormone in the firebrat, Thermobia domestica, reveals its function before its involvement in metamorphosis

   This article has 6 authors:

   1. James W Truman
   2. Lynn M Riddiford
   3. Barbora Konopova
   4. Marcela Nouzova
   5. Fernando G Noriega
   6. Michelle Herko

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study presents findings regarding the role of Juvenile Hormone in development and cell differentiation in the ametabolous insect Thermobia domestica, providing an in-depth analysis of JH's roles in a member of this basally branching group. The evidence supporting the claims of the authors is convincing, drawing on a broad range of approaches and variety of experimental techniques. While the interpretation of this work in the wider context - its relevance for the evolution of metamorphosis - is in some places somewhat speculative, the work will be of interest to evolutionary developmental biologists studying the evolution of metamorphosis, and the evolution of insects in general.

   Reviewed by eLife, Arcadia Science

9. Species -shared and -unique gyral peaks on human and macaque brains

   This article has 12 authors:

   1. Songyao Zhang
   2. Tuo Zhang
   3. Guannan Cao
   4. Jingchao Zhou
   5. Zhibin He
   6. Xiao Li
   7. Yudan Ren
   8. Tao Liu
   9. Xi Jiang
   10. Lei Guo
   11. Junwei Han
   12. Tianming Liu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important paper compares cross-species cortical folding patterns in human and non-human primates, showing that most gyral peaks shared across species are in lower-order cortical regions. The supporting evidence is solid and multi-faceted, encompassing anatomy, connectivity and gene expression. This paper will be of interest to a broad readership within the neuroscience community, especially for those interested in cross-species correspondences in brain organisation.

   Reviewed by eLife

10. Cell-autonomous role of leucine-rich repeat kinase in the protection of dopaminergic neuron survival

    This article has 7 authors:

    1. Jongkyun Kang
    2. Guodong Huang
    3. Long Ma
    4. Youren Tong
    5. Anu Shahapal
    6. Phoenix Chen
    7. Jie Shen

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This current revision builds on observations in validated conditional double KO (cDKO) mice for LRRK1 and LRRK2 that will be useful for the field, given that LRRK2 is widely expressed in the brain and periphery, and many divergent phenotypes have been attributed previously to LRRK2 expression. The manuscript presents solid data demonstrating that it is the loss of LRRK1 and LRRK2 expression within the SNpc DA cells that is not well tolerated, as it was previously unclear from past work whether neurodegeneration in the LRRK double Knock Out (DKO) was cell autonomous or the result of loss of LRRK1/LRRK2 expression in other types of cells. Future studies may pursue the biochemical mechanisms underlying the reason for the apoptotic cells noted in this study, as here, the LRRK1/LRRK2 KO mice did not replicate the dramatic increase in autophagic vacuole numbers previously noted in the germline global LRRK1/LRRK2 KO mice.

    Reviewed by eLife