eLife

Latest preprint reviews

1. Tmem263 deletion disrupts the GH/IGF-1 axis and causes dwarfism and impairs skeletal acquisition

   This article has 5 authors:

   1. Dylan C Sarver
   2. Jean Garcia-Diaz
   3. Muzna Saqib
   4. Ryan C Riddle
   5. G William Wong

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study discloses important physiological function for TMEM63 in regulating postnatal growth in mice. The data supporting the impaired body growth and skeletal phenotype as well as disrupted growth hormone/insulin-like growth factor-I (GH/IGF-I) signaling in TMEM63 knockout mice are compelling. However, to establish that alteration of hepatic GH/IGF-I signaling is the cause for observed growth and skeletal phenotype in TMEM63 knockout mice would need additional work.

   Reviewed by eLife

2. Overcoming the nutritional immunity by engineering iron-scavenging bacteria for cancer therapy

   This article has 8 authors:

   1. Sin-Wei Huang
   2. See-Khai Lim
   3. Yao-An Yu
   4. Yi-Chung Pan
   5. Wan-Ju Lien
   6. Chung-Yuan Mou
   7. Che-Ming Jack Hu
   8. Kurt Yun Mou

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study combines proteomics and a mouse model to reveal the importance of iron uptake in bacterial therapy for cancer. The evidence presented is convincing. Notably, the authors showed upregulation of iron uptake of bacteria significantly inhibits tumor growth in vivo. This paper will be of interest to a broad audience including researchers in cancer biology, cell biology, and microbiology.

   Reviewed by eLife

3. Pulsed ultrasound promotes secretion of anti-inflammatory extracellular vesicles from skeletal myotubes via elevation of intracellular calcium level

   This article has 10 authors:

   1. Atomu Yamaguchi
   2. Noriaki Maeshige
   3. Hikari Noguchi
   4. Jiawei Yan
   5. Xiaoqi Ma
   6. Mikiko Uemura
   7. Dongming Su
   8. Hiroyo Kondo
   9. Kristopher Sarosiek
   10. Hidemi Fujino

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study illuminates the effects of ultrasound-induced extracellular vesicle interactions with macrophages. It provides solid data offering insights that will be potentially useful in exploring therapeutic approaches to inflammation modulation, by suggesting that ultrasound-treated myotube vesicles can suppress macrophage inflammatory responses.

   Reviewed by eLife

4. The ORP9-ORP11 dimer promotes sphingomyelin synthesis

   This article has 8 authors:

   1. Birol Cabukusta
   2. Shalom Borst Pauwels
   3. Jimmy JLL Akkermans
   4. Niek Blomberg
   5. Aat A Mulder
   6. Roman I Koning
   7. Martin Giera
   8. Jacques Neefjes

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable manuscript systematically addresses the role of intracellular lipid transfer proteins on cellular lipid levels. It provides convincing evidence on the role of ORP9 and ORP11 in sphingolipid metabolism at the Golgi complex. This article will be of broad interest to cell biologists interested in lipid metabolism and membrane biology.

   Reviewed by eLife

5. Nifuroxazide suppresses PD-L1 expression and enhances the efficacy of radiotherapy in hepatocellular carcinoma

   This article has 20 authors:

   1. Tiesuo Zhao
   2. Pengkun Wei
   3. Congli Zhang
   4. Shijie Zhou
   5. Lirui Liang
   6. Shuoshuo Guo
   7. Zhinan Yin
   8. Sichang Cheng
   9. Zerui Gan
   10. Yuanling Xia
   11. Yongxi Zhang
   12. Sheng Guo
   13. Jiateng Zhong
   14. Zishan Yang
   15. Fei Tu
   16. Qianqing Wang
   17. Jin Bai
   18. Feng Ren
   19. Zhiwei Feng
   20. Huijie Jia

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study evaluates the effects of nifuroxazide on radiotherapy for the treatment of hepatocellular carcinoma. Solid evidence is provided to support the conclusion that nifuroxazide facilitates the downregulation of PD-L1 and may improve therapy outcomes when combined with radiotherapy, though the inclusion of additional cell lines and animal models would have strengthened the study. This work will be of interest to cancer biologists and those working in immuno-oncology.

   Reviewed by eLife

6. Metabolomics identifies and validates serum androstenedione as novel biomarker for diagnosing primary angle closure glaucoma and predicting the visual field progression

   This article has 11 authors:

   1. Shengjie Li
   2. Jun Ren
   3. Zhendong Jiang
   4. Yichao Qiu
   5. Mingxi Shao
   6. Yingzhu Li
   7. Jianing Wu
   8. Yunxiao Song
   9. Xinghuai Sun
   10. Shunxiang Gao
   11. Wenjun Cao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a valuable finding that serum androstenedione levels may provide a new biomarker for early detection and progression of glaucoma, although a single biomarker is unlikely to be singularly predictive due to the etiological heterogeneity of the disease. The strength of the evidence presented is solid, supported by multiple lines of evidence.

   Reviewed by eLife

7. Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction

   This article has 17 authors:

   1. Martin Wohlwend
   2. Pirkka-Pekka Laurila
   3. Ludger JE Goeminne
   4. Tanes Lima
   5. Ioanna Daskalaki
   6. Xiaoxu Li
   7. Giacomo von Alvensleben
   8. Barbara Crisol
   9. Renata Mangione
   10. Hector Gallart-Ayala
   11. Amélia Lalou
   12. Olivier Burri
   13. Stephen Butler
   14. Jonathan Morris
   15. Nigel Turner
   16. Julijana Ivanisevic
   17. Johan Auwerx

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This solid study presents valuable insights into the role of Cers1 on skeletal muscle function during aging, although further substantiation would help to fully establish the experimental assertions. It examines an unexplored aspect of muscle biology that is a relevant opening to future studies in this area of research.

   Reviewed by eLife

8. Immunoglobulin M regulates airway hyperresponsiveness independent of T helper 2 allergic inflammation

   This article has 13 authors:

   1. Sabelo Hadebe
   2. Anca Flavia Savulescu
   3. Jermaine Khumalo
   4. Katelyn Jones
   5. Sandisiwe Mangali
   6. Nontobeko Mthembu
   7. Fungai Musaigwa
   8. Welcome Maepa
   9. Hlumani Ndlovu
   10. Amkele Ngomti
   11. Martyna Scibiorek
   12. Javan Okendo
   13. Frank Brombacher

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study demonstrates a reduction in airway hyperresponsiveness (one of the mechanisms of allergic asthma) in the absence of IgM in a house dust mite-induced mouse model of allergic asthma. While this result suggests a new mechanistic role for IgM, the proposed new function is not as yet robustly supported by the current experiments and thus the evidence remains incomplete. A connection between the findings and human disease is not established so far, but the study will be interest to clinical immunologists.

   Reviewed by eLife

9. DePARylation is critical for S phase progression and cell survival

   This article has 13 authors:

   1. Litong Nie
   2. Chao Wang
   3. Min Huang
   4. Xiaoguang Liu
   5. Xu Feng
   6. Mengfan Tang
   7. Siting Li
   8. Qinglei Hang
   9. Hongqi Teng
   10. Xi Shen
   11. Li Ma
   12. Boyi Gan
   13. Junjie Chen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The demonstration that the PARG dePARylation enzyme is required in S phase to remove polyADP-ribose (PAR) protein adducts that are generated in response to the presence of unligated Okazaki fragments is potentially valuable, but the evidence is incomplete, and identification of relevant PARylated PARG substrates in S-phase is needed to understand the role of PARP1-mediated PARylation and PARG-catalyzed dePARylation in S-phase progression.

   Reviewed by eLife

10. Diffusive lensing as a mechanism of intracellular transport and compartmentalization

    This article has 4 authors:

    1. Achuthan Raja Venkatesh
    2. Kathy H Le
    3. David M Weld
    4. Onn Brandman

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      The authors discuss an effect, "diffusive lensing", by which particles would accumulate in high-viscosity regions – for instance in the intracellular medium. To obtain these results, the authors rely on agent-based simulations using custom rules performed with the Ito stochastic calculus convention. The "lensing effect" discussed is a direct consequence of the choice of the Ito convention without spurious drift which has been discussed before and its adequacy for the intracellular medium is insufficiently discussed and relatively doubtful. Consequently, the relevance of the presented results for biology remain unclear and based on incomplete evidence.

    Reviewed by eLife