eLife

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1. We couldn't get details of this article at this time:
   10.1101/2023.10.04.23296534

2. We couldn't get details of this article at this time:
   10.1101/2023.10.03.560754

3. We couldn't get details of this article at this time:
   10.1101/2023.10.27.564359

4. Cardiac glycosides restore autophagy flux in an iPSC-derived neuronal model of WDR45 deficiency

   This article has 18 authors:

   1. Apostolos Papandreou
   2. Nivedita Singh
   3. Lorita Gianfrancesco
   4. Dimitri Budinger
   5. Katy Barwick
   6. Alexander Agrotis
   7. Christin Luft
   8. Ying Shao
   9. An-Sofie Lenaerts
   10. Allison Gregory
   11. Suh Young Jeong
   12. Penelope Hogarth
   13. Susan Hayflick
   14. Serena Barral
   15. Janos Kriston-Vizi
   16. Paul Gissen
   17. Manju A Kurian
   18. Robin Ketteler

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable manuscript reports alterations in autophagy present in dopaminergic neurons differentiated from iPSCs of patients with WDR45 mutations. The authors identified compounds that improved the defects present in mutant cells by generating isogenic iPSC without the mutation and performing an automated drug screening. The methodological approaches are solid, but the claims still need to be completed; showing the effects of the identified compounds on iron-related alterations is crucial. The effects of these drugs in vivo would be a great addition to the study.

   Reviewed by eLife

5. We couldn't get details of this article at this time:
   10.1101/2022.10.11.511591

6. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2302.14157

7. Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation

   This article has 41 authors:

   1. Trang H Pham
   2. Kanika Bajaj Pahuja
   3. Thijs J Hagenbeek
   4. Jason Zbieg
   5. Cameron L Noland
   6. Victoria C Pham
   7. Xiaosai Yao
   8. Christopher M Rose
   9. Kristen C Browder
   10. Ho-June Lee
   11. Mamie Yu
   12. May Liang-Chu
   13. Scott Martin
   14. Erik Verschueren
   15. Jason Li
   16. Marta H Kubala
   17. Rina Fong
   18. Maria Lorenzo
   19. Paul Beroza
   20. Peter Hsu
   21. Sayantanee Paul
   22. Elisia Villemure
   23. Wendy Lee
   24. Tommy K Cheung
   25. Saundra Clausen
   26. Jennifer Lacap
   27. Yuxin Liang
   28. Jason Cheng
   29. Steve Schmidt
   30. Zora Modrusan
   31. Michael Cohen
   32. James Crawford
   33. Heinrich Jasper
   34. Alan Ashworth
   35. Jennie R Lill
   36. Shiva Malek
   37. Joachim Rudolph
   38. Ingrid E Wertz
   39. Matthew T Chang
   40. Xin Ye
   41. Anwesha Dey

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study describes two findings: first, that TEAD is subject to turnover by the ubiquitin-proteasome system involving RNF146 and Parylation, and second, the development of a pan-TEAD heterobifunctional degrader that is used to inhibit growth of a YAP-dependent cancer cell line and to characterize TEAD binding sites in the genome. Convincing evidence supports the development and specificity of the degrader. This article will be of relevance to cancer biologists and scientists interested in proteostasis, cellular signaling, and post-translation modification of proteins.

   Reviewed by eLife

8. We couldn't get details of this article at this time:
   10.1101/2024.01.08.574293

9. We couldn't get details of this article at this time:
   10.1101/2023.09.01.555946

10. We couldn't get details of this article at this time:
    10.1101/2023.11.22.568373