Latest preprint reviews

  1. Large pan-cancer cell screen coupled to (phospho-)proteomics underscores high-dose vitamin C as a potent anti-cancer agent

    This article has 18 authors:
    1. Andrea Vallés-Martí
    2. Franziska Böttger
    3. Elysia Yau
    4. Khadija Tejjani
    5. Loes Meijs
    6. Sugandhi Sharma
    7. Madiha Mumtaz
    8. Tessa Y. S. Le Large
    9. Ayse Erozenci
    10. Daniëlle Dekker
    11. Tim Schelfhorst
    12. Jan Paul Medema
    13. Irene V Bijnsdorp
    14. Jaco C Knol
    15. Sander R Piersma
    16. Thang V. Pham
    17. Elisa Giovannetti
    18. Connie R Jiménez
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This useful study utilizes proteomics analysis across a large panel of 51 cancer cell lines to elucidate mechanisms underlying the sensitivity of cancer cells to high-dose vitamin C (Ascorbate). While the associations between specific molecular pathways and sensitivity to ascorbate are interesting, a major limitation is that the study is largely descriptive and incomplete, lacking evidence on the molecular underpinnings of cancer cells' sensitivity to high-dose vitamin C.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
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