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  1. Disassembly of embryonic keratin filaments promotes pancreatic cancer metastases

    This article has 12 authors:
    1. Ryan R. Kawalerski
    2. Mariana Torrente Gonçalves
    3. Chun-Hao Pan
    4. Robert Tseng
    5. Lucia Roa-Peña
    6. Cindy V. Leiton
    7. Luke A. Torre-Healy
    8. Taryn Boyle
    9. Sumedha Chowdhury
    10. Natasha T. Snider
    11. Kenneth R. Shroyer
    12. Luisa F. Escobar-Hoyos
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The authors address the function of keratin 17 (K17), a marker of the most aggressive pancreatic ductal adenocarcinomas (PDACs). While this potentially useful study addresses a significant area of pancreatic cancer research, the lack of evidence demonstrating nuclear localization of K17 in human PDAC and the excessive reliance on a single cell line reduce the significance of the work. Moreover, the weak phenotypes of K17 phosphosite mutants provide incomplete support for the authors' mechanistic model.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
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