eLife

Latest preprint reviews

1. We couldn't get details of this article at this time:
   10.1101/2022.08.31.504599

2. We couldn't get details of this article at this time:
   10.1101/2021.08.18.456792

3. We couldn't get details of this article at this time:
   10.1101/2023.10.28.563965

4. Molecular identification of wide-field amacrine cells in mouse retina that encode stimulus orientation

   This article has 13 authors:

   1. Silvia J. Park
   2. Wanyu Lei
   3. John Pisano
   4. Andrea Orpia
   5. Jacqueline Minehart
   6. Joseph Pottackal
   7. Christin Hanke-Gogokhia
   8. Thomas E. Zapadka
   9. Cheryl Clarkson-Paredes
   10. Anastas Popratiloff
   11. Sarah E. Ross
   12. Joshua H. Singer
   13. Jonathan B. Demb

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Amacrine cells are a heterogeneous and understudied set of retinal interneurons. This study presents valuable new insights into the structure, function, and circuit connectivity of a particular subset of wide field amacrine cells (WACs). The authors use an impressive set of techniques to study structural and functional properties of these cells and to establish their postsynaptic circuit partners. Evidence for the central conclusions is solid, although some of the most interesting results could be pursued more completely.

   Reviewed by eLife

5. The ubiquitin-conjugating enzyme UBE2D/eff maintains a youthful proteome and ensures protein quality control during aging

   This article has 8 authors:

   1. Liam C Hunt
   2. Kudzai Nyamkondiwa
   3. Anna Stephan
   4. Jianqin Jiao
   5. Kanisha Kavdia
   6. Vishwajeeth Pagala
   7. Junmin Peng
   8. Fabio Demontis

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study presents findings on the role of the ubiquitin-conjugating enzyme UBE2D/eff in maintaining proteostasis during aging. The evidence supporting the conclusions is solid, although one reviewer had concerns about the readout for protein aggregation and the loss-of-function studies. In the future, mechanistic insights explaining the impact of UBE2D/eff deficiency on the accumulation of poly-ubiquitinated proteins and in shortening lifespan would be interesting. The present study is of broad interest to cell biologists working in aging and age-related diseases.

   Reviewed by eLife

6. We couldn't get details of this article at this time:
   10.1101/2023.12.08.570736

7. An Information-Theoretic Approach to Reward Rate Optimization in the Tradeoff Between Controlled and Automatic Processing in Neural Network Architectures

   This article has 3 authors:

   1. Giovanni Petri
   2. Sebastian Musslick
   3. Jonathan D. Cohen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This useful study addresses the interesting and challenging problem of how neural networks (including possibly the brain) can optimize performance while multi-tasking. The authors address this problem by introducing an information-theoretic framework that balances the costs of control and of automaticity to achieve a desired level of overall performance. They present detailed analyses of this framework, but overall the manuscript is not easily accessible to a broad audience, and the supporting evidence is currently incomplete (but could be greatly improved with substantial revisions). They use information-theoretic terminology in non-standard ways that are not clearly explained, leading to difficulties in interpreting the framework and comparing it to other computational approaches, and the relationship between their findings and empirical data is not always clear.

   Reviewed by eLife

8. We couldn't get details of this article at this time:
   10.1101/2023.08.11.552915

9. The spatial extent of anatomical connections within the thalamus varies across the cortical hierarchy in humans and macaques

   This article has 7 authors:

   1. Amber M Howell
   2. Shaun Warrington
   3. Clara Fonteneau
   4. Youngsun T Cho
   5. Stamatios N Sotiropoulos
   6. John D Murray
   7. Alan Anticevic

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This fundamental study describes patterns of anatomical connectivity between the cortex and the thalamus using magnetic resonance imaging data in humans and non-human primates. The measures are related to numerous other modalities to develop a robust understanding of the organisation of the system. The authors provide convincing evidence that there is a difference between sensory and association cortices in terms of their connectivity with the thalamus, which may have downstream effects on brain function. This work will be of interest to neuroscientists interested in the organization and dynamics of cortico-thalamic circuits.

   Reviewed by eLife

10. We couldn't get details of this article at this time:
    10.1101/2023.06.04.541603