eLife

Latest preprint reviews

1. Human and mouse cerebellar inhibitory circuits in dystonic crisis and their modulation with therapeutic stimulation

   This article has 7 authors:

   1. Alejandro G. Rey Hipolito
   2. Michael P. Dew
   3. Jason S. Gill
   4. Janelle E. Allen
   5. Karissa A. Chesky
   6. Mariam Hull
   7. Roy V. Sillitoe

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study identifies inhibitory cerebellar nuclei neurons as drivers of dystonic crisis and shows that their modulation can both induce and alleviate severe motor symptoms, proposing a cerebello-thalamic circuit mechanism with clear therapeutic relevance. The evidence is convincing, supported by rigorous bidirectional optogenetic manipulations, iCNN-to-CL thalamic monosynaptic tracing, and deep brain stimulation experiments, although the specificity of the genetic strategy remains to be fully resolved. The study will be of broad interest to neuroscientists and clinicians working on movement disorders and circuit-based therapies.

   Reviewed by eLife

2. Tonic feedback motor commands predict visuomotor learning

   This article has 3 authors:

   1. Yuto Makino
   2. Toshiki Kobayashi
   3. Daichi Nozaki

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study rigorously examines how motor learning is influenced by the feedback response to a previous movement error. Using a series of well-conducted experiments, the authors provide solid evidence that the learning response following a cursor jump does not depend on the timing of the perturbation and is influenced by the tonic component of the feedback responses. Further work is needed to determine whether this generalizes to other perturbation paradigms and to more fully understand the relationship between learning and the tonic and phasic components of the feedback response.

   Reviewed by eLife

3. A surviving beta cell subpopulation enriched in patients with T1D

   This article has 5 authors:

   1. Maxwell Spurrell
   2. Zuzana Tobiasova
   3. Jordan S. Pober
   4. John S. Tsang
   5. Kevan C Herold

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study leverages publicly available datasets to confirm, validate and extend the knowledge of the transcriptional profile of beta cells that resist destruction in Type 1 diabetes. The significance of the findings is considered valuable as they could be used for engineering stem cell-derived islets and for identifying therapeutic targets to preserve beta cell survival. The strength of the evidence is solid, in that the findings are supported by a sophisticated bioinformatic analysis pipeline and are largely consistent with and extend the existing literature.

   Reviewed by eLife

4. Feedback control of recurrent circuits imposes dynamical constraints on learning

   This article has 3 authors:

   1. Harsha Gurnani
   2. Weixuan Liu
   3. Bingni W Brunton

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study uses a feedback-driven recurrent neural network framework to explore the dynamics underlying learning of BCI decoder perturbations. With convincing evidence, the authors demonstrate that behavioral learning trajectories that match those of primates learning within-manifold and outside-manifold perturbations are likely tied to the dynamical controllability of the network and input-driven learning. This work is likely to motivate a new generation of BCI and learning experiments combining large-scale neural recordings with latent dynamical systems analyses.

   Reviewed by eLife

5. RNF25 is activated as a response to amino acid starvation-induced ribosome collisions in competition with GCN2

   This article has 3 authors:

   1. Ivan Kisly
   2. Ivo Zemp
   3. Ulrike Kutay

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides conditionally useful evidence that amino acid starvation and other stresses induce RNF25-dependent ubiquitination of RPS27A/eS31, extending this pathway beyond A-site-trapping conditions and implicating GCN1. However, incomplete and largely indirect evidence was provided to support key mechanistic claims-notably competition between RNF25 and GCN2 for GCN1 and a role in resolving ribosome collisions. Additional direct and orthogonal evidence is required to substantiate these conclusions.

   Reviewed by eLife

6. Epigenetic and 3D Genome Changes Drive Primary Trastuzumab Resistance in HER2+ Breast Cancer

   This article has 6 authors:

   1. Ningjun Duan
   2. Yijia Hua
   3. Zhengxing Zhou
   4. Nan Jin
   5. Wei Li
   6. Yongmei Yin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable finding that coordinated changes in epigenetic modifications and three-dimensional chromatin architecture may drive primary trastuzumab resistance in HER2+ breast cancer. Moreover, this manuscript identifies SGK1 as a potential therapeutic target. The evidence supporting the claims of the authors is solid, although the inclusion of a more direct validation of the key findings using tumor samples from patients with clinical trastuzumab resistance would have strengthened the study. The work will be of interest to scientists or clinicians working in the field of BCs.

   Reviewed by eLife

7. Opposing BOLD signals and oxygen metabolism largely arise from statistical uncertainty in metabolic estimates

   This article has 3 authors:

   1. Ole Goltermann
   2. Alexander Huth
   3. Christian Büchel

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript provides a timely and important statistical re-evaluation of a paper by Epp et al., on the discordance of BOLD and CMRO2 measures. The authors present a convincing case based on rigorous re-analysis of the data that these previous results arise predominantly from uncertainty in measurement, rather than physiological features. These findings have implications that are of importance to all studies of brain function using BOLD FMRI.

   Reviewed by eLife

8. How local antibiotic use, carriage duration, resistance costs and international travel shape resistance frequency in E. coli in France

   This article has 10 authors:

   1. Olivier Cotto
   2. André Birgy
   3. Mélanie Magnan
   4. Stéphane Béchet
   5. Stéphane Bonacorsi
   6. Robert Cohen
   7. Corinne Levy
   8. Forough L Nowrouzian
   9. Olivier Tenaillon
   10. François Blanquart

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable paper uses a mathematical model applied to a dataset of E coli / ESBL carriage and transmission to infer drivers of drug resistance in France. The strength of support for the study findings is incomplete. While the research question is of importance, and the mathematical model has structural and methodological integrity, numerous issues are noted: insufficient description of the data, lack of included equations and code, definitions of antibiotic use that are not complete, low sensitivity of assays for carriage, technical issues with statistical prior selection and parameter identification, and application of non-regional ECDC surveillance data to France.

   Reviewed by eLife

9. De novo design of protein binders that target DELE1 to inhibit the mitochondrial stress response

   This article has 10 authors:

   1. Rui Yang
   2. Kaiyuan Zheng
   3. McGuire Metts
   4. Yiluo Wang
   5. Danyan Yin
   6. Kevin P Li
   7. Agnieszka A Prazmowska
   8. David F Kashatus
   9. Brian Kuhlman
   10. Jie Yang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This potentially valuable study describes the development of protein binders targeting DELE1, a protein involved in activating the integrated stress response when mitochondria are perturbed (the mitoISR pathway. The strategy appears to be successful, as several designed proteins were shown to bind DELE1, disrupt DELE1 oligomerization, and attenuate ISR activation. However, the demonstration of the utility of these inhibitory binders is incomplete, particularly given the limited biological outcomes examined in the current study, thus limiting the significance of the paper in its current form.

   Reviewed by eLife

10. Temporal Dynamics of Cortical State Plasticity Following Adult Vision Loss

    This article has 3 authors:

    1. Ismaël Djerourou
    2. Maurice Ptito
    3. Matthieu P Vanni

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This useful study employs longitudinal widefield cortical imaging to investigate how bilateral vision loss reshapes spontaneous activity across the mouse cortex over time, revealing a state-dependent alteration in the locomotion-related modulation of visual cortical activity. The work provides solid support for its main findings and offers a thorough characterization of the large-scale reorganization of cortical dynamics following adult vision loss. However, the mechanistic interpretation remains limited, as the conclusions are based on a single abrupt and irreversible manipulation without sham controls and on a recording approach that cannot resolve the cell-type-specific mechanisms invoked in the discussion.

    Reviewed by eLife