Latest preprint reviews

  1. Indistinguishable network dynamics can emerge from unalike plasticity rules

    This article has 5 authors:
    1. Poornima Ramesh
    2. Basile Confavreux
    3. Pedro J. Gonçalves
    4. Tim P. Vogels
    5. Jakob H. Macke
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This work presents a valuable data-driven method to extract the "true" synaptic plasticity rule (or learning rule) operating in a neural circuit from empirical measurements of neural activity. The approach aims to train a generative adversarial network (GAN) to match neural activity measurements in terms of statistics, learning them from the data, rather than being pre-determined by the experimenter. The main conclusion is that the extracted learning rules are not unique, but rather degenerate, meaning that multiple plasticity rules can produce the same neural activity. Although the paper presents a thorough investigation using one learning rule as a case study (the Oja rule), the evidence that the results can be inferred beyond the specific numerical experiments presented in the paper is incomplete.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Structural insights into peptidoglycan hydrolysis by the FtsEX system in Escherichia coli during cell division

    This article has 11 authors:
    1. Jianwei Li
    2. Yutong He
    3. Xin Xu
    4. Martin Alcorlo
    5. Jian Shi
    6. Souvik Naskar
    7. Nicholas S Briggs
    8. David I Roper
    9. Juan A Hermoso
    10. Lok-To Sham
    11. Min Luo
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This is a potentially useful study that provides solid, yet confirmatory structural findings about the complex (FtsEX) that controls peptidoglycan remodeling during bacterial cell division. The authors capitalize on the fact that ATP binding stabilizes the FtsEX complex allowing structural characterization for this system. A model is then developed to explain ATP regulation but there is a gap between the model presented here and in vivo data reported previously.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
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