eLife

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1. We couldn't get details of this article at this time:
   10.1101/2024.01.11.24301040

2. We couldn't get details of this article at this time:
   10.1101/2024.01.06.574474

3. The intrinsically disordered N-terminus of SUMO1 is an intramolecular inhibitor of SUMO1 interactions

   This article has 12 authors:

   1. Sebastian M Richter
   2. Fan Jin
   3. Tobias Ritterhoff
   4. Aleksandra Fergin
   5. Eric Maurer
   6. Andrea Frank
   7. Michael Daube
   8. Alex Hajnal
   9. Rachel Klevit
   10. Frauke Gräter
   11. Annette Flotho
   12. Frauke Melchior

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This work demonstrates an important regulatory role of the N-terminal disordered tail of small ubiquitin-like modifier (SUMO) proteins, which modulate the function of various proteins in eukaryotic cells. The authors present convincing evidence that the N-terminal tail of SUMO inhibits SUMO's interaction with downstream effector proteins and SUMOylation targets, and that this regulatory mechanism depends on the SUMO paralogue or the phosphorylation of the N-terminal tail. This discovery significantly advances the field by providing a possible explanation of how SUMO paralogues select their effectors and SUMOylation targets.

   Reviewed by eLife

4. Serine hydroxymethyl transferase is a binding target of caprylic acid: Uncovering a novel molecular target for a herbicide and for producing caprylic acid-tolerant crops

   This article has 11 authors:

   1. Zuren Li
   2. Mugui Wang
   3. Haodong Bai
   4. Hongzhi Wang
   5. Jincai Han
   6. Likun An
   7. Dingfeng Luo
   8. Yingying Wang
   9. Wei Kuang
   10. Xiaoyi Nie
   11. Lianyang Bai

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a valuable contribution towards understanding the protein target and mechanism of action of an herbicide, which could be applied to the development of herbicide-based technologies to improve crop yields. Evidence is gathered using a variety of technical approaches that enrich and support the findings, but the methodology and the presentation of the results are incomplete.

   Reviewed by eLife

5. Cas12f1 gene drives propagate efficiently in herpesviruses and induce minimal resistance

   This article has 8 authors:

   1. Zhuangjie Lin
   2. Qiaorui Yao
   3. Keyuan Lai
   4. Kehua Jiao
   5. Xianying Zeng
   6. Guanxiong Lei
   7. Tongwen Zhang
   8. Hongsheng Dai

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable paper by Yao, Dai, and colleagues describes a viral gene drive against herpes simplex virus 1 in cell culture. The authors provided solid evidence that an engineered gene drive sequence, expressing either spCas9 or Un1Cas12f1 nuclease, could spread efficiently in the population of wild-type viruses and induce fewer drive-resistant mutations than spCas9. Limitations include a mechanistically inaccurate title, several methodologic flaws, and a paucity of descriptions of possible therapeutic applications.

   Reviewed by eLife

6. We couldn't get details of this article at this time:
   10.1101/2023.11.21.568052

7. We couldn't get details of this article at this time:
   10.1101/2023.11.05.565707

8. We couldn't get details of this article at this time:
   10.1101/2023.10.31.564973

9. We couldn't get details of this article at this time:
   10.1101/2023.10.24.563834

10. We couldn't get details of this article at this time:
    10.1101/2023.03.14.532628