eLife

Latest preprint reviews

1. Longitudinal transcriptional changes reveal genes from the natural killer cell-mediated cytotoxicity pathway as critical players underlying COVID-19 progression

   This article has 14 authors:

   1. Matias A Medina
   2. Francisco Fuentes-Villalobos
   3. Claudio Quevedo
   4. Felipe Aguilera
   5. Raul Riquelme
   6. Maria Luisa Rioseco
   7. Sebastian Barria
   8. Yazmin Pinos
   9. Mario Calvo
   10. Ian Burbulis
   11. Camila Kossack
   12. Raymond A Alvarez
   13. Jose Luis Garrido
   14. Maria Ines Barria

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable paper compares blood gene signature responses between small cohorts of individuals with mild and severe COVID-19. The authors provide solid evidence for distinct transcriptional profiles during early COVID-19 infections that may be predictive of severity, within the limitations of studying human patients displaying heterogeneity in infection timelines and limited cohort size.

   Reviewed by eLife

2. Rifampicin tolerance and growth fitness among isoniazid-resistant clinical Mycobacterium tuberculosis isolates from a longitudinal study

   This article has 16 authors:

   1. Srinivasan Vijay
   2. Nguyen Le Hoai Bao
   3. Dao Nguyen Vinh
   4. Le Thanh Hoang Nhat
   5. Do Dang Anh Thu
   6. Nguyen Le Quang
   7. Le Pham Tien Trieu
   8. Hoang Ngoc Nhung
   9. Vu Thi Ngoc Ha
   10. Phan Vuong Khac Thai
   11. Dang Thi Minh Ha
   12. Nguyen Huu Lan
   13. Maxine Caws
   14. Guy E Thwaites
   15. Babak Javid
   16. Nguyen Thuy Thuong

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study demonstrates that there is significant variation in the susceptibility of isoniazid-resistant Mycobacterium tuberculosis clinical isolates to killing by rifampicin, in some cases at the same tolerance levels as bona fide resistant strains. The evidence provided is solid, with no clear genetic marker for increased tolerance, suggesting that there may be multiple routes to achieving this phenotype. The work will be of interest to infectious disease researchers.

   Reviewed by eLife

3. Structural insights into the GTP-driven monomerization and activation of a bacterial LRRK2 homolog using allosteric nanobodies

   This article has 5 authors:

   1. Christian Galicia
   2. Giambattista Guaitoli
   3. Marcus Fislage
   4. Christian Johannes Gloeckner
   5. Wim Versées

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The fundamental study by Galicia C. et al. captured the GTP-bound active structure of CtRoco, a homolog of human LRRK2, using conformation-specific nanobodies. This convincing body of work reports the first structure of a GTP-bound ROCO protein, illustrating how GTP facilitates the dimer-to-monomer transition of CtRoco and functional activation.

   Reviewed by eLife

4. Reliance on self-reports and estimated food composition data in nutrition research introduces significant bias that can only be addressed with biomarkers

   This article has 4 authors:

   1. Javier I Ottaviani
   2. Virag Sagi-Kiss
   3. Hagen Schroeter
   4. Gunter GC Kuhnle

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study, using three bioactive compounds as a model, demonstrates that estimating the intake of food components based on food composition databases and self-reported dietary data is highly unreliable. The authors present convincing data showing the differences in the estimated quantile of intake of three bioactive compounds between biomarker and 24-hour dietary recall with food-composition database. The work will be of broad interest to the clinical nutrition research community.

   Reviewed by eLife

5. Tumor purity-related genes for predicting the prognosis and drug sensitivity of DLBCL patients

   This article has 6 authors:

   1. Zhenbang Ye
   2. Ning Huang
   3. Yongliang Fu
   4. Rongle Tian
   5. Liming Wang
   6. Wenting Huang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a predictive scoring system in DLBCL based on the expression of three tumour microenvironment-related genes. Such a scoring system seems useful for predicting tumour purity levels in DLBCL. The provided evidence showing an association between worse DLBLC prognosis and high-risk score is solid, but it is incomplete to draw a clear conclusion about the links between risk score and drug sensitivity.

   Reviewed by eLife

6. Peptidoglycan-Chi3l1 interaction shapes gut microbiota in intestinal mucus layer

   This article has 4 authors:

   1. Yan Chen
   2. Ruizhi Yang
   3. Bin Qi
   4. Zhao Shan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Supported by convincing data, this valuable study demonstrates that the Chitinase 3-like protein 1 (Chi3l1) interacts with gut microbiota and protects animals from intestinal injury in laboratory colitis model. The revised manuscript sufficiently addressed the reviewers' comments. The work will be of interest to scientists studying crosstalk between gut microbiota and inflammatory diseases.

   Reviewed by eLife

7. Ocular dominance-dependent binocular combination of monocular neuronal responses in macaque V1

   This article has 5 authors:

   1. Sheng-Hui Zhang
   2. Xing-Nan Zhao
   3. Dan-Qing Jiang
   4. Shi-Ming Tang
   5. Cong Yu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Overall, the reviewers found the significance of the work valuable to the field of visual neuroscience, particularly given the large data set and strength of the method used that allowed for spatial analysis of neuronal responses in macaque V1. The evidence was deemed compelling, owing in part to the consistency of responses across animals and the fitness of modeling. The authors have addressed the major comments from reviewers and improved the manuscript through relation to prior literature and addressing specific limitations of the method used.

   Reviewed by eLife

8. Cardiac glycosides restore autophagy flux in an iPSC-derived neuronal model of WDR45 deficiency

   This article has 18 authors:

   1. Apostolos Papandreou
   2. Nivedita Singh
   3. Lorita Gianfrancesco
   4. Dimitri Budinger
   5. Katy Barwick
   6. Alexander Agrotis
   7. Christin Luft
   8. Ying Shao
   9. An-Sofie Lenaerts
   10. Allison Gregory
   11. Suh Young Jeong
   12. Penelope Hogarth
   13. Susan Hayflick
   14. Serena Barral
   15. Janos Kriston-Vizi
   16. Paul Gissen
   17. Manju A Kurian
   18. Robin Ketteler

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable manuscript reports alterations in autophagy present in dopaminergic neurons differentiated from iPSCs of patients with WDR45 mutations. The authors identified compounds that improved the defects present in mutant cells by generating isogenic iPSC without the mutation and performing an automated drug screening. The methodological approaches are solid, but the claims still need to be completed; showing the effects of the identified compounds on iron-related alterations is crucial. The effects of these drugs in vivo would be a great addition to the study.

   Reviewed by eLife

9. Macro-scale patterns in functional connectivity associated with ongoing thought patterns and dispositional traits

   This article has 13 authors:

   1. Samyogita Hardikar
   2. Bronte Mckeown
   3. H Lina Schaare
   4. Raven Star Wallace
   5. Ting Xu
   6. Mark Edgar Lauckener
   7. Sofie Louise Valk
   8. Daniel S Margulies
   9. Adam Turnbull
   10. Boris C Bernhardt
   11. Reinder Vos de Wael
   12. Arno Villringer
   13. Jonathan Smallwood

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     These are important findings that support a link between low-dimensional brain network organisation, patterns of ongoing thought, and trait-level personality factors, making it relevant for researchers in the field of spontaneous cognition, personality, and neuropsychiatry. While this link is not entirely new, the paper brings to bear a rich dataset and a well-conducted study, to approach this question in a novel way. The evidence in support of the findings is convincing.

   Reviewed by eLife

10. The title and authors for this article are not available from our external data provider yet:
    10.48550/arxiv.2302.14157