Latest preprint reviews

  1. Staphylococcus aureus counters organic acid anion-mediated inhibition of peptidoglycan cross-linking through robust alanine racemase activity

    This article has 11 authors:
    1. Sasmita Panda
    2. Yahani P Jayasinghe
    3. Dhananjay D Shinde
    4. Emilio Bueno
    5. Amanda Stastny
    6. Blake P Bertrand
    7. Sujata S Chaudhari
    8. Tammy Kielian
    9. Felipe Cava
    10. Donald R Ronning
    11. Vinai C Thomas
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this useful study, the authors present convincing evidence linking the enzyme D-alanine-D-alanine ligase (Ddl), crucial for cell wall fortification, to organic acid exposure in Staphylococcus aureus. While it's established that organic acids impede bacterial growth, the researchers reveal a novel coping mechanism where S. aureus maintains elevated levels of D-alanine, the substrate for Ddl, to counteract this inhibition. This discovery illuminates a bacterial strategy for organic acid tolerance, offering new insights for microbiologists and potentially informing future antimicrobial approaches.

    Reviewed by eLife, Arcadia Science

    This article has 8 evaluationsAppears in 3 listsLatest version Latest activity
  2. Input-specific gating of NMDA amplification via HCN channels in mouse L2/3 pyramidal neurons

    This article has 4 authors:
    1. Viktor János Oláh
    2. Jing Wu
    3. Leonard K Kaczmarek
    4. Matthew JM Rowan
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this valuable study the authors use electrophysiology in brain slices and computer modeling and suggest that layer 2/3 pyramidal neurons of the mouse cortex have functional HCN channels on the proximal apical dendrite which allows distinct processing of input at that location from the input to distal apical dendrites. The revisions improved the solid paper but some of the concerns were not addressed sufficiently and many of these concerns could be addressed by further revision.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
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