Latest preprint reviews

  1. Cell-type-specific origins of locomotor rhythmicity at different speeds in larval zebrafish

    This article has 3 authors:
    1. Moneeza A Agha
    2. Sandeep Kishore
    3. David L McLean
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      In this fundamental study, authors present compelling evidence for the diversity in cellular and synaptic properties of one class of spinal interneurons and tie it to their differentiated role in locomotor pattern generation. The findings reported here will be of broad interest to neuroscientists in general and to motor systems scientists in particular.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  2. Downregulation of Mirlet7 miRNA family promotes Tc17 differentiation and emphysema via de-repression of RORγt

    This article has 10 authors:
    1. Phillip A Erice
    2. Xinyan Huang
    3. Matthew J Seasock
    4. Matthew J Robertson
    5. Hui-Ying Tung
    6. Melissa A Perez-Negron
    7. Shivani L Lotlikar
    8. David B Corry
    9. Farrah Kheradmand
    10. Antony Rodriguez
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study indicates a significant role for individual let-7 miRNA clusters in regulating generation of Tc17 CD8 cells and emphysema severity in a mouse model. The authors provide convincing evidence for let-7-mediated repression of the transcription factor RORgt and consequent modulation of IL-17-producing CD8 T cells, with correlated data from human emphysema material, though some of the effective let-7 clusters remain to be tested for the ability to modulate disease. The findings, which substantially advance the understanding of roles that let-7 miRNA clusters play in modulating both T cell responses and emphysematous lung disease, will be of interest to T cell and lung disease researchers.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  3. Mediodorsal thalamic nucleus mediates resistance to ethanol through Cav3.1 T-type Ca2+ regulation of neural activity

    This article has 5 authors:
    1. Charles-francois V Latchoumane
    2. Joon-Hyuk Lee
    3. Seong-Wook Kim
    4. Jinhyun Kim
    5. Hee-Sup Shin
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This valuable study investigates the relationship between neuronal dynamics in the thalamus and brain state modulation. The claims that a specific channel is a critical player in the regulation of brain-states and ethanol-resistance in mice are supported by convincing evidence. The work will be of interest to systems neuroscientists interested in brain dynamics and behavioural states.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  4. Driver lines for studying associative learning in Drosophila

    This article has 12 authors:
    1. Yichun Shuai
    2. Megan Sammons
    3. Gabriella R Sterne
    4. Karen L Hibbard
    5. He Yang
    6. Ching-Po Yang
    7. Claire Managan
    8. Igor Siwanowicz
    9. Tzumin Lee
    10. Gerald M Rubin
    11. Glenn C Turner
    12. Yoshinori Aso
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important collection of over 800 new cell type-specific driver lines will be an invaluable resource for researchers studying associative learning in Drosophila. Thoroughly characterized and well documented, this collection will permit researchers to selectively target neurons that deliver information to, or receive it from, the memory center of the fly brain called the Mushroom Body. Given the wealth of new drivers and the genetic access they provide to over 300 cell types, this compelling work will be of interest not only to researchers studying the mechanisms of associative learning but more generally to those dissecting sensorimotor circuits in the fly nervous system.

    Reviewed by eLife

    This article has 14 evaluationsAppears in 1 listLatest version Latest activity
  5. Future movement plans interact in sequential arm movements

    This article has 7 authors:
    1. Mehrdad Kashefi
    2. Sasha Reschechtko
    3. Giacomo Ariani
    4. Mahdiyar Shahbazi
    5. Alice Tan
    6. Jörn Diedrichsen
    7. J Andrew Pruszynski
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents an important set of results illuminating how movement sequences are planned. Using several different behavioural manipulations and analysis methods, the authors present compelling evidence that multiple future movements are planned simultaneously with execution, and that these future movement plans influence each other. The work will be of great interest to those studying motor control.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  6. A scale-invariant log-normal droplet size distribution below the critical concentration for protein phase separation

    This article has 8 authors:
    1. Tommaso Amico
    2. Samuel Toluwanimi Dada
    3. Andrea Lazzari
    4. Michaela Brezinova
    5. Antonio Trovato
    6. Michele Vendruscolo
    7. Monika Fuxreiter
    8. Amos Maritan
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      In this valuable study, the authors analyze droplet size distributions of multiple protein condensates and their fit to a scaling ansatz, highlighting that they exhibit features of first- and second-order phase transitions. The experimental evidence is solid, and it prompts further research into the nature of the link between percolation and phase separation.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 1 listLatest version Latest activity
  7. Speech and music recruit frequency-specific distributed and overlapping cortical networks

    This article has 5 authors:
    1. Noémie te Rietmolen
    2. Manuel R Mercier
    3. Agnès Trébuchon
    4. Benjamin Morillon
    5. Daniele Schön
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study presents valuable intracranial findings on how two types of natural auditory stimuli - speech and music - are processed in the human brain, and demonstrates that speech and music largely share network-level brain activities, thus challenging the domain-specific processing view. The evidence supporting the claims of the authors is solid. The work will be of broad interest to speech and music researchers as well as cognitive scientists in general.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  8. Hemispheric divergence of interoceptive processing across psychiatric disorders

    This article has 5 authors:
    1. Emily M Adamic
    2. Adam R Teed
    3. Jason Avery
    4. Feliberto de la Cruz
    5. Sahib Khalsa
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This fundamental study provides compelling evidence for dysgranular insular involvement in top-down and bottom-up interoceptive processing by building on previous evidence using state-of-the-art methods. Its translational application in ADE patients corroborates the assumption that the mid-insula may indeed be a locus of 'interoceptive disruption' in psychiatric disorders, which underscores the study's high relevance for both body-brain as well as clinical research.

    Reviewed by eLife

    This article has 10 evaluationsAppears in 1 listLatest version Latest activity
  9. Plastic vasomotion entrainment

    This article has 4 authors:
    1. Daichi Sasaki
    2. Ken Imai
    3. Yoko Ikoma
    4. Ko Matsui
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This manuscript presents important results indicating a plastic enhancement in the vasomotion response of pial cortical arterioles to external stimulation in awake mice using a wide range of external visual stimulation paradigms. The evidence for this interesting effect, with broad potential applications, is solid. These results are relevant for scientists and clinicians interested in the regulation of blood flow in the brain.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
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