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  1. Pharmacologic inhibition of BAF chromatin remodeling complexes as a therapeutic approach to transcription factor-dependent cancers

    This article has 31 authors:
    1. Richard C Centore
    2. Luis MM Soares
    3. Salih Topal
    4. Rishi G Vaswani
    5. Kana Ichikawa
    6. Zhifang Li
    7. Hong Fan
    8. Jeremy W Setser
    9. David L Lahr
    10. Laura E Zawadzke
    11. Xueying Chen
    12. Kimberly D Barnash
    13. Jordana Muwanguzi
    14. Neville Anthony
    15. Gabriel J Sandoval
    16. Katharine Feldman
    17. GiNell Elliott
    18. Ammar Adam
    19. David Huang
    20. Yunji Davenport
    21. Shawn Schiller
    22. Kevin J Wilson
    23. Johannes Voigt
    24. Lan Xu
    25. Martin Hentemann
    26. David S Millan
    27. Ho Man Chan
    28. Carl P Decicco
    29. Ryan G Kruger
    30. Gromoslaw A Smolen
    31. Steven F Bellon
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study constitutes a fundamental advance for the uveal melanoma research field that might be exploited to target this deadly cancer and more generally for targeting transcriptional dependency in cancers. This work substantially advances our understanding of pharmacological inhibition of SWI/SNF as a therapeutic approach for cancer. The study is well written and provides compelling evidence, including comprehensive datasets, compound screens, gene expression analysis, epigenetics, as well as animal studies.

    Reviewed by eLife

    This article has 14 evaluationsAppears in 1 listLatest version Latest activity
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