Latest preprint reviews

  1. MOB rules: Antibiotic Exposure Reprograms Metabolism to Mobilize Bacillus subtilis in Competitive Interactions

    This article has 7 authors:
    1. Yongjin Liu
    2. Sandra LaBonte
    3. Courtney Brake
    4. Carol LaFayette
    5. Adam P. Rosebrock
    6. Amy A. Caudy
    7. Paul D. Straight
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This paper reports on the transcriptional changes upon chloramphenicol-induced surface mobility of Bacillus subtilis, a phenomenon that can occur during co-incubation with Streptomyces venezuelae, a chloramphenicol producer. The work presented includes valuable and thorough transcriptomics data, which convincingly indicate that sub-lethal chloramphenicol triggers substantial changes in B. subtilis gene expression. There are, however, significant limitations and concerns whether the documented changes are causal for the phenotypes observed or simply correlated with these phenotypes; additionally, the notion that chloramphenicol triggers a 'division of labor' was incomplete and should be backed up experimentally.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  2. A packaging signal-binding protein regulates the assembly checkpoint of integrative filamentous phages

    This article has 7 authors:
    1. Ting-Yu Yeh
    2. Michael C. Feehley
    3. Patrick J. Feehley
    4. Vivian Y. Ooi
    5. Yi-Yung Hung
    6. Shao-Cheng Wang
    7. Gregory P. Contreras
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable work describes a new protein factor that is required for filamentous phage assembly. Convincing evidence is provided for the binding of PSB15 to the packaging signal of the single-stranded DNA, Trx, and cardiolipin, and a mechanism for how the phage DNA is targeted to the assembly site in the bacterial inner membrane is presented. The work will be of interest to microbiologists.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  3. Mitochondrial stress in GABAergic neurons non-cell autonomously regulates organismal health and aging

    This article has 11 authors:
    1. Laxmi Rathor
    2. Shayla Curry
    3. Youngyong Park
    4. Taylor McElroy
    5. Briana Robles
    6. Yi Sheng
    7. Wei-Wen Chen
    8. Kisuk Min
    9. Rui Xiao
    10. Myon Hee Lee
    11. Sung Min Han
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study interrogates cell non-autonomous signaling between GABAergic neurons and somatic tissues in the nematode C. elegans. The authors report that mitochondrial stress in only GABAergic neurons extends lifespan and improves healthspan, phenotypes that are dependent on the transcription factor daf-16/FOXO3a. However, while the findings may be valuable to furthering our understanding of neuronal control of aging and health, the current evidence is incomplete and additional experiments are needed to support their claims.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
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