Latest preprint reviews

  1. Mitochondrial stress in GABAergic neurons non-cell autonomously regulates organismal health and aging

    This article has 11 authors:
    1. Laxmi Rathor
    2. Shayla Curry
    3. Youngyong Park
    4. Taylor McElroy
    5. Briana Robles
    6. Yi Sheng
    7. Wei-Wen Chen
    8. Kisuk Min
    9. Rui Xiao
    10. Myon Hee Lee
    11. Sung Min Han
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study interrogates cell non-autonomous signaling between GABAergic neurons and somatic tissues in the nematode C. elegans. The authors report that mitochondrial stress in only GABAergic neurons extends lifespan and improves healthspan, phenotypes that are dependent on the transcription factor daf-16/FOXO3a. However, while the findings may be valuable to furthering our understanding of neuronal control of aging and health, the current evidence is incomplete and additional experiments are needed to support their claims.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. The cell cycle variant in multiciliated cells incorporates 2 centriole biogenesis cycles

    This article has 15 authors:
    1. Amélie-Rose Boudjema
    2. Rémi Balagué
    3. Cayla E Jewett
    4. Jacques Serizay
    5. Gina M LoMastro
    6. Olivier Mercey
    7. Adel Al Jord
    8. Adrien Candat
    9. Marion Faucourt
    10. Alexandre Schaeffer
    11. Camille Noûs
    12. Nathalie Delgehyr
    13. Andrew J Holland
    14. Nathalie Spassky
    15. Alice Meunier
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this important study, Boudjema et al. use cell culture models and high quality advanced microscopic imaging to provide detailed analyses of the cellular processes underlying centriole amplification, apical migration, and assembly of hundreds of motile cilia in multi-ciliated cells. The authors present convincing evidence showing that in these cells all the molecular and cellular steps controlling centriole biogenesis that in cycling cells extend over almost two cell cycles, occur within a single cell cycle variant. This work provides a better understanding of the regulation and order of these processes and is of interest to all cell biologists and in particular researchers studying centrioles and cilia.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
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