Latest preprint reviews

  1. A Connectome of the Male Drosophila Ventral Nerve Cord

    This article has 84 authors:
    1. Shin-ya Takemura
    2. Kenneth J Hayworth
    3. Gary B Huang
    4. Michal Januszewski
    5. Zhiyuan Lu
    6. Elizabeth C Marin
    7. Stephan Preibisch
    8. C Shan Xu
    9. John Bogovic
    10. Andrew S Champion
    11. Han SJ Cheong
    12. Marta Costa
    13. Katharina Eichler
    14. William Katz
    15. Christopher Knecht
    16. Feng Li
    17. Billy J Morris
    18. Christopher Ordish
    19. Patricia K Rivlin
    20. Philipp Schlegel
    21. Kazunori Shinomiya
    22. Tomke Stürner
    23. Ting Zhao
    24. Griffin Badalamente
    25. Dennis Bailey
    26. Paul Brooks
    27. Brandon S Canino
    28. Jody Clements
    29. Michael Cook
    30. Octave Duclos
    31. Christopher R Dunne
    32. Kelli Fairbanks
    33. Siqi Fang
    34. Samantha Finley-May
    35. Audrey Francis
    36. Reed George
    37. Marina Gkantia
    38. Kyle Harrington
    39. Gary Patrick Hopkins
    40. Joseph Hsu
    41. Philip M Hubbard
    42. Alexandre Javier
    43. Dagmar Kainmueller
    44. Wyatt Korff
    45. Julie Kovalyak
    46. Dominik Krzemiński
    47. Shirley A Lauchie
    48. Alanna Lohff
    49. Charli Maldonado
    50. Emily A Manley
    51. Caroline Mooney
    52. Erika Neace
    53. Matthew Nichols
    54. Omotara Ogundeyi
    55. Nneoma Okeoma
    56. Tyler Paterson
    57. Elliott Phillips
    58. Emily M Phillips
    59. Caitlin Ribeiro
    60. Sean M Ryan
    61. Jon Thomson Rymer
    62. Anne K Scott
    63. Ashley L Scott
    64. David Shepherd
    65. Aya Shinomiya
    66. Claire Smith
    67. Natalie Smith
    68. Alia Suleiman
    69. Satoko Takemura
    70. Iris Talebi
    71. Imaan FM Tamimi
    72. Eric T Trautman
    73. Lowell Umayam
    74. John J Walsh
    75. Tansy Yang
    76. Gerald M Rubin
    77. Louis K Scheffer
    78. Jan Funke
    79. Stephan Saalfeld
    80. Harald F Hess
    81. Stephen M Plaza
    82. Gwyneth M Card
    83. Gregory SXE Jefferis
    84. Stuart Berg
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This landmark paper introduces the generation and analysis of a connectome resource of the entire ventral nerve cord of a fruit fly which is one of the top model organisms to investigate how a nervous system forms and functions. The work introduces new and improved approaches - from tissue preparation to automated reconstruction - to generate a detailed connectome from a complex adult ventral nerve cord. This extensive new dataset provides cell type and lineage annotations, putative neurotransmitter expression information, and the potential to link to genetic driver lines, with compelling evidence to support the claims made.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
  2. Deep Mutagenesis of a Transporter for Uptake of a Non-Native Substrate Identifies Conformationally Dynamic Regions

    This article has 9 authors:
    1. Heather J Ellis
    2. Matthew Chan
    3. Balaji Selvam
    4. Evan Walter
    5. Christine A Devlin
    6. Steven K Szymanski
    7. Loren Keith Henry
    8. Diwakar Shukla
    9. Erik Procko
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      Serotonin is an important neurotransmitter and its synaptic concentration is controlled by re-uptake by the sodium-coupled serotonin transporter SERT. The manuscript by Chan et al reports results from a systematic deep mutagenesis approach to study the surface expression and APP+ (5HT analogue) transport mechanism of the human serotonin transporter. The authors complement this experimental evidence with large-scale molecular simulations of the transporter in the presence of APP+. The use of deep mutagenesis and large-scale adaptive sampling simulations is impressive, and could contribute to understanding the structural requirements for folding and how transporters evolve to recognize different substrates.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 2 listsLatest version Latest activity
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