eLife

Latest preprint reviews

1. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2306.15352

2. Axonal distribution of mitochondria maintains neuronal autophagy during aging via eIF2β

   This article has 5 authors:

   1. Kanako Shinno
   2. Yuri Miura
   3. Koichi M Iijima
   4. Emiko Suzuki
   5. Kanae Ando

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In flies defective for axonal transport of mitochondria, the authors report the upregulation of one subunit, the beta subunit, of the heterotrimeric eIF2 complex via mass spectroscopy proteomics. Neuronal overexpression of eIF2β phenocopied aspects of neuronal dysfunction observed when axonal transport of mitochondria was compromised. Conversely, lowering eIF2β expression suppressed aspects of neuronal dysfunction. While these are intriguing and useful observations, technical weaknesses limit the interpretation. On balance, the evidence supporting the current claims is suggestive but incomplete, especially concerning the characterization of the eIF2 heterotrimer and the data regarding translational regulation.

   Reviewed by eLife

3. Cell-autonomous and non-cell-autonomous effects of Arginase 2 on cardiac aging

   This article has 10 authors:

   1. Duilio M Potenza
   2. Xin Cheng
   3. Guillaume Ajalbert
   4. Andrea Brenna
   5. Marie-Noelle Giraud
   6. Aurelien Frobert
   7. Stephane Cook
   8. Kirsten D Mertz
   9. Zhihong Yang
   10. Xiu-Fen Ming

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides fundamental information on how Arg-II participates in cardiac aging. The phenotypic data provide convincing evidence of non-cell-autonomous contributions to aging-related pathologies. Overall, the study highlights the importance of intercellular signaling in maintaining cardiac health during aging.

   Reviewed by eLife

4. Ethnic and region-specific genetic risk variants of stroke and its comorbid conditions can define the variations in the burden of stroke and its phenotypic traits

   This article has 3 authors:

   1. Rashmi Sukumaran
   2. Achuthsankar S Nair
   3. Moinak Banerjee

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper provides a useful analysis of the variation of the burden of strokes across geographic regions, finding differences in the relationship between strokes and their comorbidities. This dataset and the correlations found within will be a resource for directing the focus of future investigations. The results are technically solid, but there are cases where statistical analyses are yet to be carried out to support statements of statistical significance.

   Reviewed by eLife

5. Dissecting mechanisms of ligand binding and conformational changes in the glutamine-binding protein

   This article has 18 authors:

   1. Zhongying Han
   2. Sabrina Panhans
   3. Sophie Brameyer
   4. Ecenaz Bilgen
   5. Marija Ram
   6. Anna Herr
   7. Alessandra Narducci
   8. Michael Isselstein
   9. Paul David Harris
   10. Oliver Brix
   11. Pazit Con
   12. Kirsten Jung
   13. Don C Lamb
   14. Eitan Lerner
   15. Douglas Griffith
   16. Thomas R Weikl
   17. Niels Zijlstra
   18. Thorben Cordes

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study combines a comprehensive range of biophysical, kinetic, and thermodynamic techniques, together with high-quality experimental and computational analysis, to carry out a series of well-designed experiments to explore whether glutamine-binding protein binds glutamine via an induced fit or a conformational selection process. The evidence supporting the major conclusion of the work is compelling. The work will be of broad interest to biochemists and biophysicists.

   Reviewed by eLife

6. Perturbations in eIF3 subunit stoichiometry alter expression of ribosomal proteins and key components of the MAPK signaling pathways

   This article has 11 authors:

   1. Anna Herrmannová
   2. Jan Jelínek
   3. Klára Pospíšilová
   4. Farkas Kerényi
   5. Tomáš Vomastek
   6. Kathleen Watt
   7. Jan Brábek
   8. Mahabub Pasha Mohammad
   9. Susan Wagner
   10. Ivan Topisirovic
   11. Leoš Shivaya Valášek

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study demonstrates mRNA-specific regulation of translation by subunits of the eukaryotic initiation factor complex 3 (eIF3) using convincing methods, data, and analyses. The investigations have generated important information that will be of interest to biologists studying translation regulation. However, the physiological significance of the gene expression changes that were observed is not clear.

   Reviewed by eLife

7. Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis

   This article has 20 authors:

   1. Joan Chang
   2. Adam Pickard
   3. Jeremy A Herrera
   4. Sarah O'Keefe
   5. Richa Garva
   6. Matthew Hartshorn
   7. Anna Hoyle
   8. Lewis Dingle
   9. John Knox
   10. Thomas A Jowitt
   11. Madeleine Coy
   12. Jason Wong
   13. Adam Reid
   14. Yinhui Lu
   15. Cédric Zeltz
   16. Rajamiyer V Venkateswaran
   17. Patrick T Caswell
   18. Stephen High
   19. Donald Gullberg
   20. Karl E Kadler

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study describes a novel mechanism for how collagen fibrils are formed. The authors present compelling evidence that collagen-I fibrillogenesis relies on a functional endocytic system for recycling collagen-I, with circadian-regulated VPS33b and integrin-α11 being critical for fibril assembly. This is an important study for the understanding of the pathophysiology of collagen fibrillogenesis.

   Reviewed by eLife

8. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2306.15352v3

9. Machine learning approaches identify immunologic signatures of total and intact HIV DNA during long-term antiretroviral therapy

   This article has 10 authors:

   1. Lesia Semenova
   2. Yingfan Wang
   3. Shane Falcinelli
   4. Nancie Archin
   5. Alicia D Cooper-Volkheimer
   6. David M Margolis
   7. Nilu Goonetilleke
   8. David M Murdoch
   9. Cynthia D Rudin
   10. Edward P Browne

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Semenova et al. have studied a large cross-sectional cohort of people living with HIV on suppressive antiretroviral therapy and performed high dimensional flow-cytometry for analysis with data science/machine learning approaches to investigate associations of immunological and clinical parameters and intact/total HIV DNA levels (and categorizations). The study is useful in introducing these new methods and large data set and appears mostly solid, though some of the claims were incompletely supported by the modeling results. The authors have revised the text to fairly reflect their results, yet open questions remain about utility, particularly as to the value of categorical classification (vs continuous measurement) of reservoir size.

   Reviewed by eLife

10. Associations of proton pump inhibitors with susceptibility to influenza, pneumonia, and COVID-19: Evidence from a large population-based cohort study

    This article has 13 authors:

    1. Ruijie Zeng
    2. Yuying Ma
    3. Lijun Zhang
    4. Dongling Luo
    5. Rui Jiang
    6. Huihuan Wu
    7. Zewei Zhuo
    8. Qi Yang
    9. Jingwei Li
    10. Felix W Leung
    11. Chongyang Duan
    12. Weihong Sha
    13. Hao Chen

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This useful study aimed to quantify associations between regular use of proton-pump inhibitors (PPI) with the occurrence of respiratory infections, such as influenza, pneumonia, COVID-19, and others over a period of several years. PPI use was associated with increased risks of influenza, pneumonia, but not of COVID-19, although severity and mortality of COVID-19 infections were higher in PPI users. There are inevitable weaknesses of the study design used, such as the fact that PPI use was only measured at one time-point whereas infections were assessed over a long time period, but these are appropriately highlighted in the discussion. Weaknesses are highlighted in the discussion and the study presents convincing evidence for the conclusions overall.

    Reviewed by eLife