Latest preprint reviews

  1. Novel Nuclear Roles for Testis-Specific ACTL7A and ACTL7B Supported by In Vivo Characterizations and AI Facilitated In Silico Mechanistic Modeling with Implications for Epigenetic Regulation in Spermiogenesis

    This article has 4 authors:
    1. Pierre Ferrer
    2. Srijana Upadhyay
    3. James J. Cai
    4. Tracy M. Clement
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This valuable study reports that actin-related proteins may be involved in transcriptional regulation during spermatogenesis. The supporting data remain incomplete, and more extensive disentanglement from the canonical role of these actin-related proteins and the experimental validation of in silico predictions are required. This work will be of interest to reproductive biologists and other researchers working on non-canonical roles of actin and actin-related proteins.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
  2. Comparison of Tug-of-War Models Assuming Moran versus Branching Process Population Dynamics

    This article has 3 authors:
    1. Khanh N. Dinh
    2. Monika K. Kurpas
    3. Marek Kimmel
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study uses numerical simulations to characterize and compare variants of two widely used mathematical models and then applies those models to inferring evolutionary parameters from breast cancer data. The copious numerical results will be of some interest to mathematical biologists working with similar models. The finding that many breast cancer mutations are mildly deleterious is valuable but the evidence supporting this claim is incomplete because the mathematical modelling and statistical methods are insufficiently justified and inadequately validated.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
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