eLife

Latest preprint reviews

1. TIPE drives a cancer stem-like phenotype by promoting glycolysis via PKM2/HIF-1α axis in melanoma

   This article has 10 authors:

   1. Maojin Tian
   2. Le Yang
   3. Ziqian Zhao
   4. Jigang Li
   5. Lianqing Wang
   6. Qingqing Yin
   7. Wei Hu
   8. Yunwei Lou
   9. Jianxin Du
   10. Peiqing Zhao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study investigates the molecular mechanisms underpinning how the tumor necrosis factor alpha-induced protein (TIPE) regulates aerobic glycolysis to promote tumor growth in melanoma. Convincing data using multiple independent approaches provides new insights into the molecular mechanisms underpinning aerobic glycolysis in melanoma cells. The work will be of interest to biomedical researchers working in cancer and metabolism.

   Reviewed by eLife

2. FBXO24 deletion causes abnormal accumulation of membraneless electron-dense granules in sperm flagella and male infertility

   This article has 8 authors:

   1. Yuki Kaneda
   2. Haruhiko Miyata
   3. Zoulan Xu
   4. Keisuke Shimada
   5. Maki Kamoshita
   6. Tatsuya Nakagawa
   7. Chihiro Emori
   8. Masahito Ikawa

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study reports that FBXO24 is essential for the normal formation and function of the sperm flagellum, motility, and male fertility in mice. The evidence supporting the direct role of this protein in preventing RNP granule formation in the sperm flagellum is compelling. This work will be of interest to biomedical researchers who work on testicular biology and male fertility.

   Reviewed by eLife

3. A remarkable genetic shift in a transmitted/founder virus broadens antibody responses against HIV-1

   This article has 18 authors:

   1. Swati Jain
   2. Gherman Uritskiy
   3. Marthandan Mahalingam
   4. Himanshu Batra
   5. Subhash Chand
   6. Hung V Trinh
   7. Charles Beck
   8. Woong-Hee Shin
   9. Wadad Alsalmi
   10. Gustavo Kijak
   11. Leigh A Eller
   12. Jerome Kim
   13. Daisuke Kihara
   14. Sodsai Tovanabutra
   15. Guido Ferrari
   16. Merlin L Robb
   17. Mangala Rao
   18. Venigalla B Rao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides a detailed evaluation of how HIV evades nascent immune pressure from people living with HIV followed nearly immediately after infection. There is convincing evidence that H173 mutations in the V2 loop was a key determinant of selection pressure and escape. These data are congruent with protection in the RV144 clinical trial, the only trial that showed protection from infection. Overall, this study is an important contribution to the field.

   Reviewed by eLife

4. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2301.00759v3

5. UPRER–immunity axis acts as physiological food evaluation system that promotes aversion behavior in sensing low-quality food

   This article has 3 authors:

   1. Pengfei Liu
   2. Xinyi Liu
   3. Bin Qi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable work uses unbiased approaches to discover critical molecules in C. elegans and its bacterial food for nutrition sensing and food choice, providing a framework for other studies. The data convincingly support their model that C. elegans uses UPRER and immune response pathways to evaluate sugar contents in the bacteria to change their behaviors.

   Reviewed by eLife

6. Pan-cortical 2-photon mesoscopic imaging and neurobehavioral alignment in awake, behaving mice

   This article has 2 authors:

   1. Evan D Vickers
   2. David A McCormick

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important paper presents a thoroughly detailed methodology for mesoscale-imaging of extensive areas of the cortex, either from a top or lateral perspective, in behaving mice. The examples of scientific results to be derived with this method offer promising and stimulating insights. Overall, the method and results presented are convincing and will be of interest to neuroscientists focused on cortical processing in rodents and beyond.

   Reviewed by eLife

7. X-ray structure and enzymatic study of a bacterial NADPH oxidase highlight the activation mechanism of eukaryotic NOX

   This article has 10 authors:

   1. Isabelle Petit-Hartlein
   2. Annelise Vermot
   3. Michel Thepaut
   4. Anne-Sophie Humm
   5. Florine Dupeux
   6. Jerome Dupuy
   7. Vincent Chaptal
   8. Jose Antonio Marquez
   9. Susan ME Smith
   10. Franck Fieschi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this manuscript, the authors investigate the properties of prokaryotic NADPH oxidases (NOX) and discuss the implications for NOX regulation and function. The structure of the S. pneumoniae Nox protein is an important step forward in our understanding of procaryotic NOX enzymes and the characterization and interpretation are convincing. The results will be of interest to structural biologists as well as biochemists focusing on enzymatic functions.

   Reviewed by eLife

8. SMAD4 promotes somatic-germline contact during murine oocyte growth

   This article has 3 authors:

   1. Sofia Granados-Aparici
   2. Qin Yang
   3. Hugh J Clarke

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study reports an important mechanism through which the TGF-beta signaling pathway promotes contacts between oocytes and their surrounding somatic cells by regulating the number of transzonal projections (TZPs) in mice. Convincing data support the conclusions. The work will be of interest to biomedical researchers who work on ovarian biology and female fertility.

   Reviewed by eLife

9. Experimental evolution for the recovery of growth loss due to genome reduction

   This article has 3 authors:

   1. Kenya Hitomi
   2. Yoichiro Ishii
   3. Bei-Wen Ying

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important study of the recovery of genome-reduced bacterial cells in laboratory evolution experiments, to understand how they regain their fitness. Through the analysis of gene expression and a series of tests, the authors present convincing evidence indicating distinct molecular changes in the evolved bacterial strains, although the precise mechanisms remain uncharacterized. These findings imply that diverse mechanisms are employed to offset the effects of a reduced genome, offering intriguing insights into genome evolution.

   Reviewed by eLife

10. The RNA-binding protein HuR modulates the expression of the disease-linked CCL2 rs1024611G-rs13900T haplotype

    This article has 13 authors:

    1. Feroz Akhtar
    2. Joselin Hernandez Ruiz
    3. Ya-Guang Liu
    4. Roy G Resendez
    5. Denis Feliers
    6. Liza D Morales
    7. Alvaro Diaz-Badillo
    8. Donna M Lehman
    9. Rector Arya
    10. Juan Carlos Lopez Alvarenga
    11. John Blangero
    12. Ravindranath Duggirala
    13. Srinivas Mummidi

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      CCL2 is a chemokine with immune cell chemoattractant properties, and it appears to play a role in several chronic inflammatory diseases. The RNA-binding protein HuR controls the stability and translation of CCL2 mRNA. This paper presents convincing evidence that a relatively common genetic variant tied to several disease phenotypes affects the interaction between the mRNA of CCL2 and the RNA-binding protein HuR. While the experiments cannot definitively distinguish between effects on RNA transcription and stability, CCL2 is thought to be relevant for leukocyte migration in various conditions, including chronic inflammation and cancer, and the study presents important findings that may be relevant to a broad audience.

    Reviewed by eLife