eLife

Latest preprint reviews

1. Transdifferentiation of fibroblasts into muscle cells to constitute cultured meat with tunable intramuscular fat deposition

   This article has 8 authors:

   1. Tongtong Ma
   2. Ruimin Ren
   3. Jianqi Lv
   4. Ruipeng Yang
   5. Xinyi Zheng
   6. Yang Hu
   7. Guiyu Zhu
   8. Heng Wang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents an important new technology for transdifferentiation of fibroblasts into muscle cells. The data and methods used for analysis were compelling. This study will have broad interest to cellular reprogramming biologists in particular as well as the general public.

   Reviewed by eLife

2. Dengue viremia kinetics and effects on platelet count and clinical outcomes: An analysis of 2340 patients from Vietnam

   This article has 13 authors:

   1. Nguyen Lam Vuong
   2. Nguyen Than Ha Quyen
   3. Nguyen Thi Hanh Tien
   4. Kien Duong Thi Hue
   5. Huynh Thi Le Duyen
   6. Phung Khanh Lam
   7. Dong Thi Hoai Tam
   8. Tran Van Ngoc
   9. Thomas Jaenisch
   10. Cameron P Simmons
   11. Sophie Yacoub
   12. Bridget A Wills
   13. Ronald Geskus

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript by Vuong and colleagues reports on the kinetics of viremia in a large set of individuals from Vietnam. In the large cohort, all 4 dengue serotypes are represented and the authors try to correlate viraemia measured at various days from illness onset with thrombocytopaenia and severe dengue, according to the WHO 2009 classification scheme. These are fundamental findings that provide compelling evidence of the importance of measuring viremia early in the phase of the disease. These data will help to inform the design of studies of antiviral drugs against dengue.

   Reviewed by eLife

3. The effect of combining antibiotics on resistance: A systematic review and meta-analysis

   This article has 6 authors:

   1. Berit Siedentop
   2. Viacheslav N Kachalov
   3. Christopher Witzany
   4. Matthias Egger
   5. Roger D Kouyos
   6. Sebastian Bonhoeffer

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is a methodologically state-of-the-art systematic review and meta-analysis of studies that addressed the question of whether the administration of multiple antibiotics simultaneously prevents antibiotic resistance development in individuals. The findings are solid. Rather than providing a precise answer, the synthesis of studies eligible for analysis leads to the conclusion that "our analysis could not identify any benefit or harm of using a higher or a lower number of antibiotics regarding within-patient resistance development." This article is important as it articulates the existing knowledge gap, but also serves as an example for careful future use of the meta-analysis methodology, when existing data just don't allow conclusions.

   Reviewed by eLife

4. Activity-dependent mitochondrial ROS signaling regulates recruitment of glutamate receptors to synapses

   This article has 4 authors:

   1. Rachel L Doser
   2. Kaz M Knight
   3. Ennis W Deihl
   4. Frederic J Hoerndli

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study examines an interplay between synaptic mitochondria and glutamate receptor exocytosis in C. elegans. Collectively, the solid results support the idea that mitochondrial function influences receptor dynamics at postsynaptic sites. This is important because tight control of synaptic function likely integrates several mitochondrial functions: energy production, calcium buffering, and (here) reactive oxygen species signaling.

   Reviewed by eLife

5. TEAD1 is crucial for developmental myelination, Remak bundles, and functional regeneration of peripheral nerves

   This article has 8 authors:

   1. Matthew Grove
   2. Hyukmin Kim
   3. Shuhuan Pang
   4. Jose Paz Amaya
   5. Guoqing Hu
   6. Jiliang Zhou
   7. Michel Lemay
   8. Young-Jin Son

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study demonstrates that the transcription factor TEAD1 is required for the function of Yap/Taz in Schwann cells, with conditional mouse mutants having very similar dysmyelinated phenotypes. Convincing histological evidence is shown for the role of TEAD1 itself, leaving open the function of other TEAD proteins in this system. This study will nevertheless be of great interest to researchers in the field of peripheral nerve development.

   Reviewed by eLife

6. Medial anterior prefrontal cortex stimulation downregulates implicit reactions to threats and prevents the return of fear

   This article has 7 authors:

   1. Eugenio Manassero
   2. Giulia Concina
   3. Maria Clarissa Chantal Caraig
   4. Pietro Sarasso
   5. Adriana Salatino
   6. Raffaella Ricci
   7. Benedetto Sacchetti

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents the useful observation that repetitive Transcranial Magnetic Stimulation (rTMS) over the medial prefrontal cortex (mPFC) is associated with immediate dampening effects of conditioned responses and generalization of these responses to similar cues. Additionally, the effects were still present one week later, in the absence of any stimulation. However, the evidence supporting the claims of the authors is incomplete. The main outcome data (skin conductance response) have been normalized and standardized in suboptimal ways and, most critically, no comparisons are being made with the strength of conditioned responses during acquisition. If the observations hold, when based on within-subject comparisons, the work will be of interest to psychologists and neuroscientists working on interventions into aberrant emotional memories.

   Reviewed by eLife

7. Disrupting abnormal neuronal oscillations with adaptive delayed feedback control

   This article has 5 authors:

   1. Domingos Leite de Castro
   2. Miguel Aroso
   3. A Pedro Aguiar
   4. David B Grayden
   5. Paulo Aguiar

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Large populations of neurons are capable of entering pathological synchronous oscillations under a variety of conditions and work over many decades has found ways to disrupt such oscillations using stimulation in both open loop and closed loop configurations. This study adds useful results and methodology to this line of research, by providing solid evidence that delayed feedback control via electrical stimulation can, under certain conditions, terminate network level oscillations in cultured cortical neurons. The study provides analyses and simulation results that shed light on why some networks respond to such feedback control while others do not.

   Reviewed by eLife

8. Interactions between circuit architecture and plasticity in a closed-loop cerebellar system

   This article has 3 authors:

   1. Hannah L Payne
   2. Jennifer L Raymond
   3. Mark S Goldman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Payne et al. present a novel model that predicts the sites and directions of plasticity within the vestibular cerebellum to explain the basis for learned adjustments to reflexive eye movements in monkeys. The work is solid; the model is well constrained by prior biological observations and makes an important prediction about the level of feedback available to the cerebellar cortex post-learning. Overall, a number of exciting and testable experiments will likely be motivated by this study.

   Reviewed by eLife

9. Hammerhead-type FXR agonists induce an enhancer RNA Fincor that ameliorates nonalcoholic steatohepatitis in mice

   This article has 7 authors:

   1. Jinjing Chen
   2. Ruoyu Wang
   3. Feng Xiong
   4. Hao Sun
   5. Byron Kemper
   6. Wenbo Li
   7. Jongsook Kemper

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Using unbiased transcriptional profiling, the study reports a fundamental discovery of a novel hepatic lncRNA, FincoR, which regulates FXR. The convincing findings have therapeutic implications in the treatment of MASH. The authors use state-of-the-art methodology and use unbiased transcriptomic profiling and epigenetic profiling, including validation in mouse models and human samples.

   Reviewed by eLife

10. Prdm1 positively regulates liver Group 1 ILCs cancer immune surveillance and preserves functional heterogeneity

    This article has 13 authors:

    1. Jitian He
    2. Le Gao
    3. Peiying Wang
    4. Wing Keung Chan
    5. Yiran Zheng
    6. Yumo Zhang
    7. Jiaman Sun
    8. Xue Li
    9. Jiming Wang
    10. Xiao-Hong Li
    11. Huaiyong Chen
    12. Zhouxin Yang
    13. Youwei Wang

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      The authors investigated the requirement and function of Blimp1/Prdm1 in murine natural killer (NK) cells and the ILC1 lineage of innate lymphoid cells, using a conditional knockout model. The single-cell mRNA-seq data provided here represent a valuable resource for the community, but the lack of mechanistic investigations leaves the study partially incomplete. The work will be of interest to the fields of innate lymphoid cell biology and tissue immunology.

    Reviewed by eLife