eLife

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1. Toxin-based screening of C-terminal tags in Escherichia coli reveals the exceptional potency of ssrA-like degrons

   This article has 2 authors:

   1. Patrick C. Beardslee
   2. Karl R. Schmitz

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study employs an innovative genetic selection-based approach to identify short peptide sequences that target bacterial proteins for degradation. Using random mutagenesis they identified 5 amino acid long "degrons" that target the toxin VapC for degradation permitting survival. They provide compelling data that degrons ending in Ala-Ala are selectively recognized by the ClpXP protease and identify the sequence FKLVA as a particularly significant target. As a whole, there is enthusiasm about the author's findings, although there are also some improvements that could be made to increase the clarity and impact, mostly in the form of revisions to the text.

   Reviewed by eLife

2. We couldn't get details of this article at this time:
   10.1101/2023.04.19.537456

3. We couldn't get details of this article at this time:
   10.21203/rs.3.rs-3251230/v3

4. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2403.16382

5. We couldn't get details of this article at this time:
   10.1101/2024.05.01.592074

6. We couldn't get details of this article at this time:
   10.1101/2024.04.23.590680

7. We couldn't get details of this article at this time:
   10.1101/2024.04.22.590550

8. We couldn't get details of this article at this time:
   10.1101/2023.12.19.572452

9. We couldn't get details of this article at this time:
   10.1101/2024.04.09.588715

10. We couldn't get details of this article at this time:
    10.1101/2024.04.09.588665