eLife

Latest preprint reviews

1. Neural evidence of functional compensation for fluid intelligence in healthy ageing

   This article has 5 authors:

   1. Ethan Knights
   2. Richard N Henson
   3. Alexa Morcom
   4. Daniel J Mitchell
   5. Kamen A Tsvetanov

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides an important advancement of knowledge by showing neural functional compensation in the brains of healthy older adults completing a fluid-intelligence task. Validated whole-brain voxel-wide analyses and multivariate Bayesian approaches provide compelling evidence that supports the claims of the authors. The work delivers methods for quantifying reserve and compensation in future studies and will be of interest to researchers in the field of the neuroscience of healthy aging.

   Reviewed by eLife

2. Mechanism of barotaxis in marine zooplankton

   This article has 3 authors:

   1. Luis Alberto Bezares Calderón
   2. Réza Shahidi
   3. Gáspár Jékely

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study addresses the question of how certain zooplankton achieve barotaxis, directed locomotion in response to changes in hydraulic pressure. The authors provide compelling evidence that the response involves ciliary photoreceptors interacting with motoneurons. This work should be of broad interest to scientists working on mechanosensation, cilia, locomotion, and photoreceptors.

   Reviewed by eLife

3. Identification of pharmacological inducers of a reversible hypometabolic state for whole organ preservation

   This article has 42 authors:

   1. Megan M Sperry
   2. Berenice Charrez
   3. Haleh Fotowat
   4. Erica Gardner
   5. Kanoelani Pilobello
   6. Zohreh Izadifar
   7. Tiffany Lin
   8. Abigail Kuelker
   9. Sahith Kaki
   10. Michael Lewandowski
   11. Shanda Lightbown
   12. Ramses Martinez
   13. Susan Marquez
   14. Joel Moore
   15. Maria Plaza-Oliver
   16. Adama M Sesay
   17. Kostyantyn Shcherbina
   18. Katherine Sheehan
   19. Takako Takeda
   20. Daniela Del Campo
   21. Kristina Andrijauskaite
   22. Exal Cisneros
   23. Riley Lopez
   24. Isabella Cano
   25. Zachary Maxwell
   26. Israel Jessop
   27. Rafa Veraza
   28. Leon Bunegin
   29. Thomas J Percival
   30. Jaclyn Yracheta
   31. Jorge J Pena
   32. Diandra M Wood
   33. Zachary T Homas
   34. Cody J Hinshaw
   35. Jennifer Cox-Hinshaw
   36. Olivia G Parry
   37. Justin J Sleeter
   38. Erik K Weitzel
   39. Michael Levin
   40. Michael Super
   41. Richard Novak
   42. Donald E Ingber

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Pharmacological induction of physiological slowing combined with organ perfusion systems could provide a novel therapeutic strategy for tissue and organ preservation. Using a Xenopus model, the authors provide important findings on a use of drug to slow down metabolism for the purpose of organ preservation. The authors provide compelling evidence that SNC80 can rapidly and reversibly slow biochemical and metabolic activities while preserving cell and tissue viability. This approach may be beneficial for transplantation, trauma management, and improving organ survival in remote and low-resource settings

   Reviewed by eLife

4. Interchromosomal segmental duplication drives translocation and loss of P. falciparum histidine-rich protein 3

   This article has 11 authors:

   1. Nicholas J Hathaway
   2. Isaac E Kim
   3. Neeva WernsmanYoung
   4. Sin Ting Hui
   5. Rebecca Crudale
   6. Emily Y Liang
   7. Christian P Nixon
   8. David Giesbrecht
   9. Jonathan J Juliano
   10. Jonathan B Parr
   11. Jeffrey A Bailey

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This work provides important insight into the mechanisms of hrp2 and particularly hrp3 deletion generation. The generation of additional long-read data alongside a new analysis of 19,000 public short-read sequenced genomes makes this the most detailed investigation currently available on this topic, which has high public health importance and also basic biological interest. The revised version of the manuscript provides convincing evidence for the proposed mechanisms.

   Reviewed by eLife

5. Pial collaterals develop through mosaic colonization of capillaries by arterial and microvascular endothelial cells

   This article has 7 authors:

   1. Tijana Perovic
   2. Irene Hollfinger
   3. Stefanie Mayer
   4. Janet Lips
   5. Monika Dopatka
   6. Christoph Harms
   7. Holger Gerhardt

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides insights into the developmental origin of endothelial cells found in blood vessels called pial collaterals. The work is important, as collateral capacity can strongly influence the trajectory of outcomes with vascular blockage, and the approaches are novel and overall convincing; however, some mechanistic claims are only partially supported, and collateral characterization is incomplete. Given the clear positive correlation between pial collateral flow and improved stroke outcome, this study will be of interest to vascular biologists and clinicians caring for stroke patients.

   Reviewed by eLife

6. The molecular logic of Gtr1/2- and Pib2-dependent TORC1 regulation in budding yeast

   This article has 6 authors:

   1. Jacob H Cecil
   2. Cristina M Padilla
   3. Austin A Lipinski
   4. Paul Langlais
   5. Xiangxia Luo
   6. Andrew P Capaldi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The study presents valuable findings concerning how a highly conserved signal transduction pathway helps budding yeast cells adapt their growth to nitrogen sources of differing qualities. However, the evidence is incomplete for the authors' main claim that the pathway adopts three distinct states depending on the nitrogen source. The presented data, particularly phospho-proteomic datasets, will be of interest to the cell growth signaling community.

   Reviewed by eLife

7. Stem-loop and circle-loop TADs generated by directional pairing of boundary elements have distinct physical and regulatory properties

   This article has 4 authors:

   1. Wenfan Ke
   2. Miki Fujioka
   3. Paul Schedl
   4. James B Jaynes

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable work investigates the role of boundary elements in the formation of 3D genome architecture. The authors established a specific model system that allowed them to manipulate boundary elements and examine the resulting genome topology. The work yielded the first demonstration of the existence of stem and circle loops in a genome and confirms a model which had been posited based on extensive prior genetic work, providing insights into how 3D genome topologies affect enhancer-promoter communication. The evidence is solid, although the degree of generalization remains uncertain.

   Reviewed by eLife

8. Inhibition of the UFD-1-NPL-4 complex triggers an aberrant immune response in Caenorhabditis elegans

   This article has 3 authors:

   1. Rajneesh Rao
   2. Alejandro Aballay
   3. Jogender Singh

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this valuable manuscript, Rao and colleagues investigate the UFD-1/NPL-4 complex, which is involved in extracting misfolded proteins in the plasma membrane and the accumulation of pathogenic bacteria in the intestine. Using convincing methods, the authors find that knockdown of the ufd-1 and npl-4 genes leads to shortened lifespan of the nematode C. elegans and reduced accumulation of the bacterial pathogen P. aeruginosa in the intestine.

   Reviewed by eLife

9. Chromosome structure in Drosophila is determined by boundary pairing not loop extrusion

   This article has 8 authors:

   1. Xinyang Bing
   2. Wenfan Ke
   3. Miki Fujioka
   4. Amina Kurbidaeva
   5. Sarah Levitt
   6. Mike Levine
   7. Paul Schedl
   8. James B Jaynes

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable work presents elegant experimental data from the Drosophila embryo supporting the notion that interactions among specific loci, called boundary elements, contribute to topologically associated domain (TAD) formation and gene regulation. The evidence supporting boundary:boundary pairing as a determinant of 3D structures is compelling; however, an inability to deplete loop extruders formally leaves open a possible contribution of loop extrusion. This study will be of interest to the nuclear structure community, particularly those using Drosophila as a model.

   Reviewed by eLife

10. Structure of scavenger receptor SCARF1 and its interaction with lipoproteins

    This article has 14 authors:

    1. Yuanyuan Wang
    2. Fan Xu
    3. Guangyi Li
    4. Chen Cheng
    5. Bowen Yu
    6. Ze Zhang
    7. Dandan Kong
    8. Fabao Chen
    9. Yali Liu
    10. Zhen Fang
    11. Longxing Cao
    12. Yang Yu
    13. Yijun Gu
    14. Yongning He

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      SCARF1 is a scavenger membrane-bound receptor that binds modified versions of lipoproteins and has a significant role in maintaining lipid homeostasis. This useful study reports the crystal structure of SCARF1 and identifies putative binding sites for modified lipoproteins. Supported by a convincing set of experimental approaches, this study advances our knowledge of how scavenger receptors clear modified lipoproteins to maintain lipid homeostasis.

    Reviewed by eLife