eLife

Latest preprint reviews

1. Mediodorsal thalamic nucleus mediates resistance to ethanol through Cav3.1 T-type Ca2+ regulation of neural activity

   This article has 5 authors:

   1. Charles-francois V Latchoumane
   2. Joon-Hyuk Lee
   3. Seong-Wook Kim
   4. Jinhyun Kim
   5. Hee-Sup Shin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study investigates the relationship between neuronal dynamics in the thalamus and brain state modulation. The claims that a specific channel is a critical player in the regulation of brain-states and ethanol-resistance in mice are supported by convincing evidence. The work will be of interest to systems neuroscientists interested in brain dynamics and behavioural states.

   Reviewed by eLife

2. Driver lines for studying associative learning in Drosophila

   This article has 12 authors:

   1. Yichun Shuai
   2. Megan Sammons
   3. Gabriella R Sterne
   4. Karen L Hibbard
   5. He Yang
   6. Ching-Po Yang
   7. Claire Managan
   8. Igor Siwanowicz
   9. Tzumin Lee
   10. Gerald M Rubin
   11. Glenn C Turner
   12. Yoshinori Aso

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important collection of over 800 new cell type-specific driver lines will be an invaluable resource for researchers studying associative learning in Drosophila. Thoroughly characterized and well documented, this collection will permit researchers to selectively target neurons that deliver information to, or receive it from, the memory center of the fly brain called the Mushroom Body. Given the wealth of new drivers and the genetic access they provide to over 300 cell types, this compelling work will be of interest not only to researchers studying the mechanisms of associative learning but more generally to those dissecting sensorimotor circuits in the fly nervous system.

   Reviewed by eLife

3. Future movement plans interact in sequential arm movements

   This article has 7 authors:

   1. Mehrdad Kashefi
   2. Sasha Reschechtko
   3. Giacomo Ariani
   4. Mahdiyar Shahbazi
   5. Alice Tan
   6. Jörn Diedrichsen
   7. J Andrew Pruszynski

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents an important set of results illuminating how movement sequences are planned. Using several different behavioural manipulations and analysis methods, the authors present compelling evidence that multiple future movements are planned simultaneously with execution, and that these future movement plans influence each other. The work will be of great interest to those studying motor control.

   Reviewed by eLife

4. A scale-invariant log-normal droplet size distribution below the critical concentration for protein phase separation

   This article has 8 authors:

   1. Tommaso Amico
   2. Samuel Toluwanimi Dada
   3. Andrea Lazzari
   4. Michaela Brezinova
   5. Antonio Trovato
   6. Michele Vendruscolo
   7. Monika Fuxreiter
   8. Amos Maritan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this valuable study, the authors analyze droplet size distributions of multiple protein condensates and their fit to a scaling ansatz, highlighting that they exhibit features of first- and second-order phase transitions. The experimental evidence is solid, and it prompts further research into the nature of the link between percolation and phase separation.

   Reviewed by eLife

5. Speech and music recruit frequency-specific distributed and overlapping cortical networks

   This article has 5 authors:

   1. Noémie te Rietmolen
   2. Manuel R Mercier
   3. Agnès Trébuchon
   4. Benjamin Morillon
   5. Daniele Schön

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents valuable intracranial findings on how two types of natural auditory stimuli - speech and music - are processed in the human brain, and demonstrates that speech and music largely share network-level brain activities, thus challenging the domain-specific processing view. The evidence supporting the claims of the authors is solid. The work will be of broad interest to speech and music researchers as well as cognitive scientists in general.

   Reviewed by eLife

6. Hemispheric divergence of interoceptive processing across psychiatric disorders

   This article has 5 authors:

   1. Emily M Adamic
   2. Adam R Teed
   3. Jason Avery
   4. Feliberto de la Cruz
   5. Sahib Khalsa

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study provides compelling evidence for dysgranular insular involvement in top-down and bottom-up interoceptive processing by building on previous evidence using state-of-the-art methods. Its translational application in ADE patients corroborates the assumption that the mid-insula may indeed be a locus of 'interoceptive disruption' in psychiatric disorders, which underscores the study's high relevance for both body-brain as well as clinical research.

   Reviewed by eLife

7. Plastic vasomotion entrainment

   This article has 4 authors:

   1. Daichi Sasaki
   2. Ken Imai
   3. Yoko Ikoma
   4. Ko Matsui

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript presents important results indicating a plastic enhancement in the vasomotion response of pial cortical arterioles to external stimulation in awake mice using a wide range of external visual stimulation paradigms. The evidence for this interesting effect, with broad potential applications, is solid. These results are relevant for scientists and clinicians interested in the regulation of blood flow in the brain.

   Reviewed by eLife

8. Transcriptional inhibition after irradiation occurs preferentially at highly expressed genes in a manner dependent on cell cycle progression

   This article has 6 authors:

   1. Zulong Chen
   2. Xin Wang
   3. Xinlei Gao
   4. Nina Arslanovic
   5. Kaifu Chen
   6. Jessica K Tyler

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important work describes a compelling analysis of DNA damage-induced changes in nascent RNA transcripts, and a genome-wide screening effort to identify the responsible proteins. A significant discovery is the inability of arrested cells to undergo DNA damage-induced gene silencing, which, is attributed to an inability to mediate ATM-induced transcriptional repression. This work will be of general interest to the DNA damage, repair, and transcription fields, with a potential impact on the cancer field.

   Reviewed by eLife

9. A chemically induced attenuated strain of Candida albicans generates robust protective immune responses and prevents systemic candidiasis development

   This article has 4 authors:

   1. Swagata Bose
   2. Satya Ranjan Sahu
   3. Abinash Dutta
   4. Narottam Acharya

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a useful strategy in which the authors devised a simple method to attenuate Candida albicans and deliver a live whole-cell vaccine in a mouse model of systemic candidiasis. The reviewers are not convinced about the completeness of the study: the strength of the evidence is incomplete and could be augmented with additional experiments to more fully characterize vaccine efficacy and host immune responses.

   Reviewed by eLife

10. Liver regeneration by a population of midzone-located mesenchymal-hepatocyte hybrid cells

    This article has 6 authors:

    1. Guo Yu
    2. Shaoyang Zhang
    3. Ana Romo
    4. Soma Biswas
    5. Baojie Li
    6. Jing Li

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This study is partly useful as it corroborates what is already known about the elevated proliferation capacity of mid lobular hepatocytes in liver regeneration. Lineage tracing and scRNAseq studies are powerful for the investigation of such heterogeneous hepatocyte proliferation capacity. Nevertheless, based on experimental limitations, incomplete method description and inadequate data analyses the presented data are insufficient to support the proposed conclusions of a mesenchymal-hepatocyte hybrid population in the murine liver.

    Reviewed by eLife