eLife

Latest preprint reviews

1. Sensorimotor mechanisms selective to numerosity derived from individual differences

   This article has 5 authors:

   1. Giovanni Anobile
   2. Irene Petrizzo
   3. Daisy Paiardini
   4. David Burr
   5. Guido Marco Cicchini

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This potentially important paper addresses the question of how numerical information is represented in the human brain. Experimental findings are interpreted as providing evidence for a sensorimotor mechanism that involves channels, each tuned to a particular numerical range. While this is an interesting application of methodologies used to identify the presence of channels, the evidence supporting the claim that these have a sensorimotor basis is incomplete.

   Reviewed by eLife

2. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2112.05098

3. The reuniens nucleus of the thalamus facilitates hippocampo-cortical dialogue during sleep

   This article has 6 authors:

   1. Diellor Basha
   2. Amirmohammad Azarmehri
   3. Elian Proulx
   4. Sylvain Chauvette
   5. Maryam Ghorbani
   6. Igor Timofeev

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The important manuscript presents convincing evidence of temporal correlations during specific oscillatory activity between the prefrontal cortex, thalamic nucleus reuniens, and the hippocampus, in naturally sleeping animals. Such correlations represent solid evidence to support the notion that the thalamic nucleus reuniens participates in the hippocampal and prefrontal cortex dialogue subserving memory processes.

   Reviewed by eLife

4. Sex differences in discrimination behavior and orbitofrontal engagement during context-gated reward prediction

   This article has 5 authors:

   1. Sophie Peterson
   2. Amanda Maheras
   3. Brenda Wu
   4. Jose Chavira
   5. Ronald Keiflin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable manuscript reveals sex differences in bi-conditional Pavlovian learning and conditional behavior. Males learn hierarchical context-cue-outcome associations more quickly, but females show more stable and robust task performance. These sex differences are related to cellular activation in the orbitofrontal cortex. Although the evidence supporting these claims is convincing, some assertions of sex differences in context-dependent discrimination behaviour may be slightly overstated yet have strong potential to guide future research to clarify the nature of these differences. The results will be of interest to many behavioural neuroscientists, particularly those who investigate sex-specific behaviours.

   Reviewed by eLife

5. A genome-wide nucleosome-resolution map of promoter-centered interactions in human cells corroborates the enhancer-promoter looping model

   This article has 4 authors:

   1. Arkadiy K Golov
   2. Alexey A Gavrilov
   3. Noam Kaplan
   4. Sergey V Razin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Identifying chromatin interactions with high sensitivity and resolution at the genome-wide scale continues to be technically challenging. This study introduces findings based on the improved MNase-based proximity ligation method, MChIP-C, which enables genome-wide measurement of chromatin interactions at single-nucleosome resolution. The evidence presented in this manuscript is convincing, and the technological advancements will be valuable for the study of 3D genome architecture.

   Reviewed by eLife

6. Biobank-wide association scan identifies risk factors for late-onset Alzheimer’s disease and endophenotypes

   This article has 19 authors:

   1. Donghui Yan
   2. Bowen Hu
   3. Burcu F Darst
   4. Shubhabrata Mukherjee
   5. Brian W Kunkle
   6. Yuetiva Deming
   7. Logan Dumitrescu
   8. Yunling Wang
   9. Adam Naj
   10. Amanda Kuzma
   11. Yi Zhao
   12. Hyunseung Kang
   13. Sterling C Johnson
   14. Cruchaga Carlos
   15. Timothy J Hohman
   16. Paul K Crane
   17. Corinne D Engelman
   18. Alzheimer’s Disease Genetics Consortium (ADGC)
   19. Qiongshi Lu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In the last 15 years, large-scale association studies (GWAS) have served to estimate the association between genome-wide common variants and a large number of disparate traits and diseases in humans. This valuable method provides a new way to find correlations between the genetic component of a phenotype of interest, and all this wealth of genetic information. This software adds as a new tool to investigate genetic correlation between traits, and to generate new mechanistic hypotheses and dissect the role of the observed associations in disease heterogeneity. The results of the application of their method are solid and generally agree with what others have seen using similar AD and UKB data.

   Reviewed by eLife

7. Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology

   This article has 26 authors:

   1. Harshvardhan Gazula
   2. Henry FJ Tregidgo
   3. Benjamin Billot
   4. Yael Balbastre
   5. Jonathan Williams-Ramirez
   6. Rogeny Herisse
   7. Lucas J Deden-Binder
   8. Adria Casamitjana
   9. Erica J Melief
   10. Caitlin S Latimer
   11. Mitchell D Kilgore
   12. Mark Montine
   13. Eleanor Robinson
   14. Emily Blackburn
   15. Michael S Marshall
   16. Theresa R Connors
   17. Derek H Oakley
   18. Matthew P Frosch
   19. Sean I Young
   20. Koen Van Leemput
   21. Adrian V Dalca
   22. Bruce Fischl
   23. Christine L MacDonald
   24. C Dirk Keene
   25. Bradley T Hyman
   26. Juan E Iglesias

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors of this study implemented an important toolset for 3D reconstruction and segmentation of dissection photographs, which could serve as an alternative for cadaveric and ex vivo MRIs. The tools were tested on synthetic and real data with compelling performance. This toolset could further contribute to the study of neuroimaging-neuropathological correlations.

   Reviewed by eLife

8. The seminal odorant binding protein Obp56g is required for mating plug formation and male fertility in Drosophila melanogaster

   This article has 7 authors:

   1. Nora C Brown
   2. Benjamin Gordon
   3. Caitlin E McDonough-Goldstein
   4. Snigdha Misra
   5. Geoffrey D Findlay
   6. Andrew G Clark
   7. Mariana Federica Wolfner

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study describes an atypical role of the odorant binding protein Obp56g in mating plug formation in Drosophila melanogaster suggesting that Obps may play roles in reproduction in addition to their originally described roles in olfaction. Mutant males lacking Obp56g fail to induce the formation of a mating plug in the female reproductive tract-leading to ejaculate loss and reduced sperm storage. The evidence supporting the claims of the authors is solid and compelling. The work will be of interest to biologists studying Obps and seminal fluid protein function and their evolution.

   Reviewed by eLife

9. Behavioral discrimination and olfactory bulb encoding of odor plume intermittency

   This article has 7 authors:

   1. Ankita Gumaste
   2. Keeley L Baker
   3. Michelle Izydorczak
   4. Aaron C True
   5. Ganesh Vasan
   6. John P Crimaldi
   7. Justus Verhagen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important work addresses an interesting question for the vertebrate olfactory community of whether mice can discriminate odorant intermittency to help them navigate the environment. The data were collected and analyzed using solid methodology, however, the paper seems to fall short in demonstrating that animal is actually sensitive to intermittency but not other flow parameters. The work will be of interest to researchers working on sensory neurobiology and animal behavior.

   Reviewed by eLife

10. Resource-rational account of sequential effects in human prediction

    This article has 3 authors:

    1. Arthur Prat-Carrabin
    2. Florent Meyniel
    3. Rava Azeredo da Silveira

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This work is relevant to understanding how people represent uncertain events in the world around them and make decisions, with broad applications to economic behavior. It addresses a long-standing empirical puzzle from a novel perspective, where the authors propose that sequential effects in perceptual decisions may emerge from rational choices under cognitive resource constraints rather than adjustments to changing environments. Two new computational models have been constructed to predict behavior under two different constraints, among which the one assuming higher cost for more precise beliefs is better supported by new experimental data. The conclusion may be further strengthened by comparison with alternative models and (optionally) evidence from additional data.

    Reviewed by eLife