eLife

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1. Neurexins control the strength and precise timing of glycinergic inhibition in the auditory brainstem

   This article has 8 authors:

   1. He-Hai Jiang
   2. Ruoxuan Xu
   3. Xiupeng Nie
   4. Zhenghui Su
   5. Xiaoshan Xu
   6. Ruiqi Pang
   7. Yi Zhou
   8. Fujun Luo

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides important insights into the role of neurexins as regulators of synaptic strength and timing at the glycinergic synapse between neurons of the medial nucleus of the trapezoid body and the lateral superior olive, key components of the auditory brainstem circuit involved in computing sound source location from differences in the intensity of sounds arriving at the two ears. Through an elegant combination of genetic manipulation, fluorescence in-situ hybridization, ex vivo slice electrophysiology, pharmacology and optogenetics, the authors provide compelling and rigorous evidence to support their claims. While further work is needed to reveal the mechanistic basis by which neurexins influence glycinergic neurotransmission, this work will be of interest to both auditory and synaptic neuroscientists.

   Reviewed by eLife

2. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2305.04587

3. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2305.04587v3

4. Fast evolution of SOS-independent multi-drug resistance in bacteria

   This article has 10 authors:

   1. Le Zhang
   2. Yunpeng Guan
   3. YuenYee Cheng
   4. Nural N Cokcetin
   5. Amy L Bottomley
   6. Andrew Robinson
   7. Elizabeth J Harry
   8. Antoine M van Oijen
   9. Qian Peter Su
   10. Dayong Jin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable observation of how deletion of a major repair protein in bacteria can facilitate the rise of mutations that confer resistance against a range of different antibiotics. The data presented are convincing, and the authors addressed the concerns raised by the reviewers in their resubmission, improving the strength of their findings.

   Reviewed by eLife

5. Metabolic disruption impairs ribosomal protein levels, resulting in enhanced aminoglycoside tolerance

   This article has 2 authors:

   1. Rauf Shiraliyev
   2. Mehmet A Orman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The findings of this study are valuable as they challenge the dogma regarding the link between lowered bacterial metabolism and tolerance to aminoglycosides. The authors propose that the well-known tolerance to AG of mutants such as those of complexes I and II is not due to a decrease in the proton motive force and thus antibiotic uptake. The results presented here are convincing.

   Reviewed by eLife

6. Activating SRC/MAPK signaling via 5-HT1A receptor contributes to the effect of vilazodone on improving thrombocytopenia

   This article has 17 authors:

   1. Ling Zhou
   2. Chengyang Ni
   3. Ruixue Liao
   4. Xiaoqin Tang
   5. Taian Yi
   6. Mei Ran
   7. Miao Huang
   8. Rui Liao
   9. Xiaogang Zhou
   10. Dalian Qin
   11. Long Wang
   12. Feihong Huang
   13. Xiang Xie
   14. Ying Wan
   15. Jiesi Luo
   16. Yiwei Wang
   17. Jianming Wu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a rather valuable finding that vilazodone can restore the normal platelet level through regulating 5-HT1A receptor. The evidence supporting the claims of the authors is solid, although inclusion of more cell lines and more detailed analysis of the results would have strengthened the study. The work will be of interest to scientists working in the field of thrombocytopenia.

   Reviewed by eLife

7. Polysaccharide breakdown products drive degradation-dispersal cycles of foraging bacteria through changes in metabolism and motility

   This article has 11 authors:

   1. Astrid Katharina Maria Stubbusch
   2. Johannes M Keegstra
   3. Julia Schwartzman
   4. Sammy Pontrelli
   5. Estelle E Clerc
   6. Samuel Charlton
   7. Roman Stocker
   8. Cara Magnabosco
   9. Olga T Schubert
   10. Martin Ackermann
   11. Glen G D'Souza

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript is a valuable contribution to our understanding of foraging behaviors in marine bacteria. The authors present a conceptual model for how a marine bacterial species consumes an abundant polysaccharide. Using experiments in microfluidic devices and through measurements of motility and gene expression, the authors offer convincing evidence that the degradation products of polysaccharide digestion can stimulate motility.

   Reviewed by eLife

8. Mapping variation in the morphological landscape of human cells with optical pooled CRISPRi screening

   This article has 8 authors:

   1. Ramon Lorenzo D. Labitigan
   2. Adrian L. Sanborn
   3. Cynthia V. Hao
   4. Caleb K. Chan
   5. Nathan M. Belliveau
   6. Eva M. Brown
   7. Mansi Mehrotra
   8. Julie A. Theriot

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this important study by Theriot et al., the authors utilize an impressive set of innovative approaches to conduct a CRISPRi pooled screen in human cells using large-scale microscopy screen data. They leverage an improved barcoding approach to identify genes targeted in specific cells and examine the effects on cell morphology using high-dimensional phenotypic analysis. The method and data presented are compelling.

   Reviewed by eLife

9. Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability

   This article has 21 authors:

   1. Keene L Abbott
   2. Ahmed Ali
   3. Bradley I Reinfeld
   4. Amy Deik
   5. Sonu Subudhi
   6. Madelyn D Landis
   7. Rachel A Hongo
   8. Kirsten L Young
   9. Tenzin Kunchok
   10. Christopher S Nabel
   11. Kayla D Crowder
   12. Johnathan R Kent
   13. Maria Lucia L Madariaga
   14. Rakesh K Jain
   15. Kathryn E Beckermann
   16. Caroline A Lewis
   17. Clary B Clish
   18. Alexander Muir
   19. W Kimryn Rathmell
   20. Jeffrey Rathmell
   21. Matthew G Vander Heiden

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides an important finding that the local abundance of metabolites impacts the biology of the tumor microenvironment by utilizing kidney tumors from patients and adjacent normal tissues. The evidence supporting the claims of the authors is convincing. The work will of interest to the research community working on metabolism and kidney cancer especially.

   Reviewed by eLife

10. Visuo-motor updating in individuals with heightened autistic traits

    This article has 2 authors:

    1. Antonella Pomè
    2. Eckart Zimmermann

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This important study shows that a high autism quotient in neurotypical adults is associated with suboptimal motor planning and visual updating after eye movements, suggesting a disrupted efference copy mechanism. The implication is that abnormal visuomotor updating may contribute to sensory overload - a key symptom in autism spectrum disorder. The evidence presented is convincing, with few limitations, and should be of broad interest to neuroscientists at large.

    Reviewed by eLife