eLife

Latest preprint reviews

1. Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons

   This article has 14 authors:

   1. Guoqiang Wang
   2. Ryan J Guasp
   3. Sangeena Salam
   4. Edward Chuang
   5. Andrés Morera
   6. Anna J Smart
   7. David Jimenez
   8. Sahana Shekhar
   9. Emily Friedman
   10. Ilija Melentijevic
   11. Ken C Nguyen
   12. David H Hall
   13. Barth D Grant
   14. Monica Driscoll

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study explores the potential influence of physiologically relevant mechanical forces on the extrusion of vesicles from C. elegans neurons. The authors provide compelling evidence to support the idea that uterine distension per se can induce vesicular extrusion from adjacent neurons. Overall, this work will be of interest to neuroscientists and investigators in the extracellular vesicle and proteostasis fields.

   Reviewed by eLife

2. Working memory gating in obesity is moderated by striatal dopaminergic gene variants

   This article has 10 authors:

   1. Nadine Herzog
   2. Hendrik Hartmann
   3. Lieneke Katharina Janssen
   4. Arsene Kanyamibwa
   5. Maria Waltmann
   6. Peter Kovacs
   7. Lorenz Deserno
   8. Sean Fallon
   9. Arno Villringer
   10. Annette Horstmann

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The present study provides valuable evidence on the neurochemical mechanisms underlying working memory in obesity. The authors' approach considering specific working memory operations (maintenance, updating) and putative dopaminergic genes is solid, though the inclusion of a more direct measure of dopamine signaling would have strengthened the work.

   Reviewed by eLife

3. Differential conformational dynamics in two type-A RNA-binding domains drive the double-stranded RNA recognition and binding

   This article has 5 authors:

   1. Firdousi Parvez
   2. Devika Sangpal
   3. Harshad Paithankar
   4. Zainab Amin
   5. Jeetender Chugh

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a useful comparison of the dynamic properties of two RNA-binding domains. The data collection and analysis are solid, making excellent use of a suite of NMR experiments and ITC data. Nonetheless, reported evidence was found to only partially support the proposed connection between the backbone dynamics of the tandem domains and their RNA binding activity. This work will be of interest to biophysicists working on RNA-binding proteins.

   Reviewed by eLife

4. Uncovering the BIN1-SH3 interactome underpinning centronuclear myopathy

   This article has 10 authors:

   1. Boglarka Zambo
   2. Evelina Edelweiss
   3. Bastien Morlet
   4. Luc Negroni
   5. Matyas Pajkos
   6. Zsuzsanna Dosztanyi
   7. Soren Ostergaard
   8. Gilles Trave
   9. Jocelyn Laporte
   10. Gergo Gogl

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This work describes a novel affinity interactomics approach that allows investigators to identify networks of protein-protein interactions in cells. The important findings presented here describe the application of this technique to the SH3 domain of the membrane remodeling Bridging Integrator 1 (BIN1), the truncation of which leads to centronuclear myopathy. The authors present solid evidence that BIN1 SH3 engages with an unexpectedly high number of cellular proteins, many of which are linked to skeletal muscle disease, and evidence is presented to suggest that BIN1 may play a role in mitosis creating the potential for new avenues in drug development efforts. Some of the findings, however, remain rather preliminary, lack sufficient replicates and may require additional experiments to definitively support the conclusions.

   Reviewed by eLife

5. Aberrant methylation and expression of TNXB promote chondrocyte apoptosis and extracullar matrix degradation in hemophilic arthropathy via AKT signaling

   This article has 12 authors:

   1. Jiali Chen
   2. Qinghe Zeng
   3. Xu Wang
   4. Rui Xu
   5. Weidong Wang
   6. Yuliang Huang
   7. Qi Sun
   8. Wenhua Yuan
   9. Pinger Wang
   10. Di Chen
   11. Peijian Tong
   12. Hongting Jin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study identifies the TNXB-AKT pathway as a potential mechanism underlying hemophilia-associated cartilage degeneration. The evidence supporting the conclusions is convincing, with murine and human patient evidence as well as genome-wide DNA methylation analysis. This paper would be of interest to cell biologists and biochemists working on the field of musculoskeletal disorders.

   Reviewed by eLife

6. Zika virus remodels and hijacks IGF2BP2 ribonucleoprotein complex to promote viral replication organelle biogenesis

   This article has 13 authors:

   1. Clément Mazeaud
   2. Stefan Pfister
   3. Jonathan E Owen
   4. Higor Sette Pereira
   5. Flavie Charbonneau
   6. Zachary E Robinson
   7. Anaïs Anton
   8. Cheyanne L Bemis
   9. Aïssatou Aïcha Sow
   10. Trushar R Patel
   11. Christopher J Neufeldt
   12. Pietro Scaturro
   13. Laurent Chatel-Chaix

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study combines multidisciplinary approaches to examine the role of insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) as a potential novel host dependency factor for Zika virus. The main claims are supported by the data but remain incomplete. The evidence would be strengthened by improving the western blot analyses and adjusting the toning of their claims in relation to the role of IGF2BP2 for viral replication. With the experimental evidence strengthened, this work will be of interest to virologists working on flaviviruses.

   Reviewed by eLife

7. How did UGA codon translation as tryptophan evolve in certain ciliates? A critique of Kachale et al. 2023 Nature

   This article has 6 authors:

   1. Estienne Carl Swart
   2. Christiane Emmerich
   3. Kwee Boon Brandon Seah
   4. Minakshi Singh
   5. Yekaterina Shulgina
   6. Aditi Singh

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The manuscript explores the ways in which the genetic code evolves, specifically how stop codons are reassigned to become sense codons. The authors present phylogenetic data showing that mutations at position 67 of the termination factor are present in organisms that nevertheless use the UGA codon as a stop codon, thereby questioning the importance of this position in the reassignment of stop codons. Alternative models on the role of eRF1 would reflect a more balanced view of the data. Overall, the data are solid and these findings will be valuable to the genomic/evolution fields.

   Reviewed by eLife

8. Quantity of SARS-CoV-2 RNA copies exhaled per minute during natural breathing over the course of COVID-19 infection

   This article has 21 authors:

   1. Gregory Lane
   2. Guangyu Zhou
   3. Judd F. Hultquist
   4. Lacy M. Simons
   5. Ramon Lorenzo- Redondo
   6. Egon A. Ozer
   7. Danielle M. McCarthy
   8. Michael G. Ison
   9. Chad J. Achenbach
   10. Xinkun Wang
   11. Ching Man Wai
   12. Eugene Wyatt
   13. Alan Aalsburg
   14. Qiaohan Yang
   15. Torben Noto
   16. Arghavan Alisoltani
   17. Daniel Ysselstein
   18. Rajeshwar Awatramani
   19. Robert Murphy
   20. Grant Theron
   21. Christina Zelano

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable manuscript by Lane introduces an exciting way to measure SARS-CoV-2 aerosolized shedding using a disposable exhaled breath condensate collection device (EBCD). The paper draws the conclusion that the contagious shedding of the virus via the aerosol route persists at a high level until 8 days after symptoms. While the methodology is potentially of high importance and the paper is clearly written, the conclusions are incomplete and only partially supported by the data.

   Reviewed by eLife

9. Analysis of fast calcium dynamics of honey bee olfactory coding

   This article has 4 authors:

   1. Marco Paoli
   2. Antoine Wystrach
   3. Brice Ronsin
   4. Martin Giurfa

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     How neural circuits represent sensory signals during and after stimulus presentation is a central question in neuroscience. Here, a model of the insect mushroom body, constructed from simple, known synaptic connectivity rules, is shown to convincingly explain stimulus discrimination and associative memory, even in the presence of variability in the input signals as experimentally measured from the antennal lobe of the honeybee. This important study makes testable predictions for the role of specific neurons in a neural circuit for associative memory, of relevance to any study of neural network design and operation.

   Reviewed by eLife

10. Tracking the neurodevelopmental trajectory of beta band oscillations with optically pumped magnetometer-based magnetoencephalography

    This article has 13 authors:

    1. Lukas Rier
    2. Natalie Rhodes
    3. Daisie O Pakenham
    4. Elena Boto
    5. Niall Holmes
    6. Ryan M Hill
    7. Gonzalo Reina Rivero
    8. Vishal Shah
    9. Cody Doyle
    10. James Osborne
    11. Richard W Bowtell
    12. Margot Taylor
    13. Matthew J Brookes

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This study provides important evidence supporting the ability of a new type of neuroimaging, OPM-MEG system, to measure beta-band oscillation in sensorimotor tasks in 2-14 years old children and to demonstrate the corresponding development changes, since neuroimaging methods with high spatiotemporal resolution that could be used on small children are quite limited. The evidence supporting the conclusion is compelling. This work will be of interest to the neuroimaging and developmental science communities.

    Reviewed by eLife