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  1. Slow kinesin-dependent microtubular transport facilitates ribbon synapse assembly in developing cochlear inner hair cells

    This article has 7 authors:
    1. Roos Anouk Voorn
    2. Michael Sternbach
    3. Amandine Jarysta
    4. Vladan Rankovic
    5. Basile Tarchini
    6. Fred Wolf
    7. Christian Vogl
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study provides important information about the formation of ribbon synapses in mouse cochlear hair cells, which facilitate the temporally-precise transmission of acoustic information to the auditory nerve. Live-cell imaging provides compelling evidence that ribbon precursor volume is dynamically modified by fission and fusion events on microtubules, but some of the other evidence included, particularly in relation to the directed transport of these precursors to the hair cell active zone is incomplete. These findings will be of interest to neuroscientists studying synapse formation and function and should inspire further research into the molecular basis for synaptic ribbon maturation.

    Reviewed by eLife

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