eLife

Latest preprint reviews

1. Ketamine induces multiple individually distinct whole-brain functional connectivity signatures

   This article has 26 authors:

   1. Flora Moujaes
   2. Jie Lisa Ji
   3. Masih Rahmati
   4. Joshua B Burt
   5. Charles Schleifer
   6. Brendan D Adkinson
   7. Aleksandar Savic
   8. Nicole Santamauro
   9. Zailyn Tamayo
   10. Caroline Diehl
   11. Antonija Kolobaric
   12. Morgan Flynn
   13. Nathalie Rieser
   14. Clara Fonteneau
   15. Terry Camarro
   16. Junqian Xu
   17. Youngsun Cho
   18. Grega Repovs
   19. Sarah K Fineberg
   20. Peter T Morgan
   21. Erich Seifritz
   22. Franz X Vollenweider
   23. John H Krystal
   24. John D Murray
   25. Katrin H Preller
   26. Alan Anticevic

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents valuable findings regarding inter-individual variability in the neural and behavioral effects of ketamine. The methodological approach used to characterize this variability is compelling, but the evidence to support the specificity of the changes and their genetic correlates is incomplete. The study would benefit from a more thorough examination of the specificity of the pharmacological and genetic results.

   Reviewed by eLife

2. Collaborative hunting in artificial agents with deep reinforcement learning

   This article has 4 authors:

   1. Kazushi Tsutsui
   2. Ryoya Tanaka
   3. Kazuya Takeda
   4. Keisuke Fujii

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this study, deep learning methods are deployed in the context of a group hunting scenario wherein two predators pursue a single prey. Through deep learning, the two predators achieve higher predation success than occurs with single predators. Much of the evidence in this important study is solid, with implications for future work on the ethology and simulation of cooperative behaviors.

   Reviewed by eLife

3. Discovering non-additive heritability using additive GWAS summary statistics

   This article has 7 authors:

   1. Samuel Pattillo Smith
   2. Gregory Darnell
   3. Dana Udwin
   4. Julian Stamp
   5. Arbel Harpak
   6. Sohini Ramachandran
   7. Lorin Crawford

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides a valuable investigation into whether phenotypic variance due to interactions between genetic variants can be measured using genome-wide association summary statistics. The authors present a method, i-LDSC, that uses statistics on the correlations between genotypes at different loci (linkage disequilibrium) to estimate the phenotypic variance explained by both additive genetic effects and pairwise interactions. While the authors present extensive simulations on the performance of their method and empirical results indicating the presence of epistasis (as they define epistasis) it is unclear how their method and results relate to the traditional definitions of additive and non-additive genetic effects, which are different from the authors' definitions.

   Reviewed by eLife

4. The title and authors for this article are not available from our external data provider yet:
   10.31219/osf.io/preprints/osf

5. Enabling brain-wide mapping of layer-specific functional connectivity at 3T via layer-dependent fMRI with draining-vein suppression

   This article has 3 authors:

   1. Wei-Tang Chang
   2. Weili Lin
   3. Kelly S Giovanello

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study presents a possible solution for a significant problem - that of draining vein sensitivity in functional MRI, which complicates the interpretability of laminar-fMRI results. The addition of a low diffusion-weighted gradient is presented to remove the draining vein signal and obtain functional responses with higher spatial fidelity. However, the strength of the evidence is incomplete, and most tests appear to have been done only in a single subject. Significance thresholds in presented maps are very low and most cortical depth-dependent response profiles do not differ from baseline, even in the BOLD data shown as reference. Curiously, even BOLD group data fails to replicate the well-known pattern of draining towards the cortical surface.

   Reviewed by eLife

6. Causal role of the frontal eye field in attention-induced ocular dominance plasticity

   This article has 7 authors:

   1. Fangxing Song
   2. Xue Dong
   3. Jiaxu Zhao
   4. Jue Wang
   5. Xiaohui Sang
   6. Xin He
   7. Min Bao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study combines psychophysics, fMRI, and TMS to reveal a causal role of FEF in generating an attention-induced ocular dominance shift, with potential relevance for clinical applications. The evidence supporting the claims of the authors is convincing. The work will be of broad interest to perceptual and cognitive neuroscience.

   Reviewed by eLife

7. UGGT1-mediated reglucosylation of N-glycan competes with ER-associated degradation of unstable and misfolded glycoproteins

   This article has 18 authors:

   1. Satoshi Ninagawa
   2. Masaki Matsuo
   3. Deng Ying
   4. Shuichiro Oshita
   5. Shinya Aso
   6. Kazutoshi Matsushita
   7. Mai Taniguchi
   8. Akane Fueki
   9. Moe Yamashiro
   10. Kaoru Sugasawa
   11. Shunsuke Saito
   12. Koshi Imami
   13. Yasuhiko Kizuka
   14. Tetsushi Sakuma
   15. Takashi Yamamoto
   16. Hirokazu Yagi
   17. Koichi Kato
   18. Kazutoshi Mori

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important manuscript demonstrates that UGGT1 is involved in preventing the premature degradation of endoplasmic reticulum (ER) glycoproteins through the re-glucosylation of their N-linked glycans following release from the calnexin/calreticulin lectins. The authors include a wealth of convincing data in support of their findings, although extending these findings to other types of substrates, such as secreted proteins, could further demonstrate the global importance of this mechanism for protein trafficking through the secretory pathway. This work will be of interest to scientists interested in ER protein quality control, proteostasis, and protein trafficking.

   Reviewed by eLife

8. On the pH-dependence of α-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation

   This article has 11 authors:

   1. Lukas Frey
   2. Dhiman Ghosh
   3. Bilal M Qureshi
   4. David Rhyner
   5. Ricardo Guerrero-Ferreira
   6. Aditya Pokharna
   7. Witek Kwiatkowski
   8. Tetiana Serdiuk
   9. Paola Picotti
   10. Roland Riek
   11. Jason Greenwald

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents important findings on the different polymorphs of alpha-synuclein filaments that form at various pH's during in vitro assembly reactions with purified recombinant protein. Of particular note is the discovery of two new polymorphs (1M and 5A) that form in PBS buffer at pH 7. The strength of the evidence presented is convincing. The work will be of interest to biochemists and biophysicists working on protein aggregation and amyloids.

   Reviewed by eLife

9. The archerfish uses motor adaptation in shooting to correct for changing physical conditions

   This article has 3 authors:

   1. Svetlana Volotsky
   2. Opher Donchin
   3. Ronen Segev

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study showed convincing evidence that archerfishes can adapt their shooting behaviors to airflow perturbations. The fish also exhibits adaptive behaviors indicative of an egocentric representation of the perturbation, though direct evidence is missing. Hence, this work will be of interest to those interested in cross-species comparisons for motor learning.

   Reviewed by eLife

10. Homeostatic regulation of rapid eye movement sleep by the preoptic area of the hypothalamus

    This article has 10 authors:

    1. John J Maurer
    2. Alexandra Lin
    3. Xi Jin
    4. Jiso Hong
    5. Nicholas Sathi
    6. Romain Cardis
    7. Alejandro Osorio-Forero
    8. Anita Lüthi
    9. Franz Weber
    10. Shinjae Chung

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This valuable study advances our understanding of the brain nuclei involved in rapid-eye movement (REM) sleep regulation. Using a combination of imaging, electrophysiology, and optogenetic tools, the study provides convincing evidence that inhibitory neurons in the preoptic area of the hypothalamus influence REM sleep. This work will be of interest to neurobiologists working on the brain circuits of sleep.

    Reviewed by eLife