eLife

Latest preprint reviews

1. Feature sequence-based genome mining uncovers the hidden diversity of bacterial siderophore pathways

   This article has 14 authors:

   1. Shaohua Gu
   2. Yuanzhe Shao
   3. Karoline Rehm
   4. Laurent Bigler
   5. Di Zhang
   6. Ruolin He
   7. Ruichen Xu
   8. Jiqi Shao
   9. Alexandre Jousset
   10. Ville-Petri Friman
   11. Xiaoying Bian
   12. Zhong Wei
   13. Rolf Kümmerli
   14. Zhiyuan Li

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study presents a novel pipeline for the large-scale genomic prediction of members of the non-ribosomal peptide group of pyoverdines based on a dataset from nearly 2000 Pseudomonas genomes. The advance presented in this study is based on convincing evidence. This study of bacterial siderophores has broad theoretical and practical implications beyond a singular subfield.

   Reviewed by eLife

2. Syngap1 regulates the synaptic drive and membrane excitability of Parvalbumin-positive interneurons in mouse auditory cortex

   This article has 7 authors:

   1. Ruggiero Francavilla
   2. Bidisha Chattopadhyaya
   3. Jorelle Linda Damo Kamda
   4. Vidya Jadhav
   5. Said Kourrich
   6. Jacques L Michaud
   7. Graziella Di Cristo

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides valuable evidence indicating that SynGap1 regulates the synaptic drive and membrane excitability of parvalbumin- and somatostatin-positive interneurons in the auditory cortex. Since haplo-insufficiency of SynGap1 has been linked to intellectual disabilities without a well-defined underlying cause, the central question of this study is timely. The experimental data is solid, as in their revisions the authors successfully addressed questions related to changes in thalamocortical presynaptic excitability, the contradiction between spontaneous and mini EPSCs data, and the anatomical analysis of excitatory synapses.

   Reviewed by eLife

3. CD81+ senescent-like fibroblasts exaggerate inflammation and activate neutrophils via C3/C3aR1 axis in periodontitis

   This article has 11 authors:

   1. Liangliang Fu
   2. Chenghu Yin
   3. Qin Zhao
   4. Shuling Guo
   5. Wenjun Shao
   6. Ting Xia
   7. Quan Sun
   8. Liangwen Chen
   9. Jinghan Li
   10. Min Wang
   11. Haibin Xia

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study identifies a population of CD81-positive fibroblasts showing senescence signatures that can activate neutrophils through the C3/C3aR1 axis, hence contributing to the inflammatory response in periodontitis. Solid evidence, combining in vitro and in vivo analyses and mouse and human data, supports these findings. The revised manuscript has addressed many concerns significantly. The work would be of interest to researchers working in the senescence and oral medicine fields.

   Reviewed by eLife

4. Insights into metabolic heterogeneity of colorectal cancer gained from fluorescence lifetime imaging

   This article has 14 authors:

   1. Anastasia D Komarova
   2. Snezhana D Sinyushkina
   3. Ilia D Shchechkin
   4. Irina N Druzhkova
   5. Sofia A Smirnova
   6. Vitaliy M Terekhov
   7. Artem M Mozherov
   8. Nadezhda I Ignatova
   9. Elena E Nikonova
   10. Evgeny A Shirshin
   11. Liubov E Shimolina
   12. Sergey V Gamayunov
   13. Vladislav I Shcheslavskiy
   14. Marina V Shirmanova

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a valuable finding on the heterogeneity of tumour metabolism using fluorescence lifetime imaging, measured across 4 cell lines, 4 tumour types of in vivo mouse models, and 29 patient samples. The indication is that the level of heterogeneity of cellular metabolism increases with model complexity and demonstrates high heterogeneity at a clinical level. The evidence supporting the claims of the authors is solid, and at the revision stage, the authors have included additional samples from 8 patients in the data pool, which is helpful for the conclusions that the authors are trying to draw. The work will be of interest to medical biologists developing methods for quantifying metabolic heterogeneity.

   Reviewed by eLife

5. Spinal V1 inhibitory interneuron clades differ in birthdate, projections to motoneurons, and heterogeneity

   This article has 9 authors:

   1. Andrew E Worthy
   2. Joanna T Anderson
   3. Alicia R Lane
   4. Laura J Gomez-Perez
   5. Anthony A Wang
   6. Ronald W Griffith
   7. Andre F Rivard
   8. Jay B Bikoff
   9. Francisco J Alvarez

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides a valuable description of subtypes of V1 neurons, including birthdates and connections to motor neurons. V1 neurons are one of the main groups of inhibitory neurons in the spinal cord. The methods of data collection and analysis are convincing. This work will interest developmental biologists and neuroscientists working on spinal circuits.

   Reviewed by eLife

6. An antimicrobial drug recommender system using MALDI-TOF MS and dual-branch neural networks

   This article has 3 authors:

   1. Gaetan De Waele
   2. Gerben Menschaert
   3. Willem Waegeman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study presents a machine learning model to recommend effective antimicrobial drugs from patients' samples analysed with mass spectrometry. The evidence supporting the claims of the authors is convincing. This work will be of interest to computational biologists, microbiologists, and clinicians.

   Reviewed by eLife

7. Implicit motor adaptation patterns in a redundant motor task manipulating a stick with both hands

   This article has 2 authors:

   1. Toshiki Kobayashi
   2. Daichi Nozaki

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable finding on how the sensorimotor control system deals with redundancy within our body, based on a novel bimanual task. The evidence supporting the authors' claims is convincing, as demonstrated over four different experiments. The work will be of interest to researchers from the motor control community and related fields, and further investigation into the interpretation of the findings could increase the generalisation of the study to a broader audience.

   Reviewed by eLife

8. Scalable, optically-responsive human neuromuscular junction model reveals convergent mechanisms of synaptic dysfunction in familial ALS

   This article has 5 authors:

   1. Daniel Chen
   2. Polyxeni Philippidou
   3. Bianca de Freitas Brenha
   4. Ashleigh E. Schaffer
   5. Helen C. Miranda

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important study describing a neuromuscular junction co-culture system using human cells that the authors use to study the synaptic consequences of ALS mutations. The data supporting the system are solid and show the value of using myotubes and motor neurons from the same donor. The study will be of interest to researchers who model neuromuscular junction disorders, however, the authors could more comprehensively compare and contrast their system with previous literature describing other similar models. There are also technical weaknesses that limit the interpretation of specific findings.

   Reviewed by eLife

9. Differences in HIV-1 reservoir size, landscape characteristics, and decay dynamics in acute and chronic treated HIV-1 Clade C infection

   This article has 10 authors:

   1. Kavidha Reddy
   2. Guinevere Q Lee
   3. Nicole Reddy
   4. Tatenda JB Chikowore
   5. Kathy Baisley
   6. Krista L Dong
   7. Bruce D Walker
   8. Xu G Yu
   9. Mathias Lichterfeld
   10. Thumbi Ndung'u

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This fundamental, clearly written, and timely manuscript links the timing of ART with the kinetics of total and intact proviral HIV DNA. The conclusions are interesting and novel, and the importance of the work is high because the focus is on African women and clade C virus, both of which are understudied in the HIV reservoir field. The strength of the evidence is compelling. Overall, this work will be of very high interest to scientists and clinicians in the HIV cure/persistence fields.

   Reviewed by eLife, Rapid Reviews Infectious Diseases

10. The microbiome interacts with the circadian clock and dietary composition to regulate metabolite cycling in the Drosophila gut

    This article has 5 authors:

    1. Yueliang Zhang
    2. Sara B Noya
    3. Yongjun Li
    4. Jichao Fang
    5. Amita Sehgal

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This study presents valuable findings about daily rhythm changes of the Drosophila melanogaster adult gut metabolome, which is shown to be dependent on the circadian clock genotype, dietary regime and composition, and gut microbiota. The phenomena observed are supported by convincing experimental evidence. The general descriptive approach limits the power of the proposed conclusions. The work will be of interest to a broad range of physiology specialists

    Reviewed by eLife