eLife

Latest preprint reviews

1. A mitochondrial carrier transports glycolytic intermediates to link cytosolic and mitochondrial glycolysis in the human gut parasite Blastocystis

   This article has 6 authors:

   1. Eva Pyrihová
   2. Martin S King
   3. Alannah C King
   4. M Rey Toleco
   5. Mark van der Giezen
   6. Edmund RS Kunji

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study identifies candidate mitochondrial metabolite carriers in stramenopile protists that may allow these divergent eukaryotes to maintain a compartmentalized glycolytic pathway. This study fills a gap in our understanding of glycolysis evolution and opens avenues for drug design to combat stramenopile parasites. The evidence, based on phylogenetic analysis, thermostability shift assays, and in vitro reconstitution of transport reactions, is convincing, albeit lacking direct in vivo confirmation of the physiological function of these candidates.

   Reviewed by eLife

2. Integrative models of visually guided steering in Drosophila

   This article has 5 authors:

   1. Angel Canelo
   2. Hyosun Kim
   3. Yeon Kim
   4. Jeongmin Park
   5. Anmo J Kim

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study investigates the implementation of an efference copy mechanism in the visual flight control system of Drosophila, a topic of broad interest to sensorimotor neuroscientists. Although the behavioral data and computational analyses are each individually solid, there is limited quantitative evaluation of how the model predictions compare to the experimental data.

   Reviewed by eLife

3. Structures of wild-type and a constitutively closed mutant of connexin26 shed light on channel regulation by CO2

   This article has 5 authors:

   1. Deborah H Brotherton
   2. Sarbjit Nijjar
   3. Christos G Savva
   4. Nicholas Dale
   5. Alexander David Cameron

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents valuable new structures of a carbamylation-mimetic K125E mutant of the Cx26 gap junction channel uncovering the cytoplasmic loop structure and information about the closed state of the channel. The cryo-EM maps are in high quality and serve as strong foundations for dissecting the gating mechanism by CO2, providing convincing evidence in support of a mechanism where CO2-mediated carbamylation of Lys125 shifts the conformational equilibrium towards a state where the N-terminus occludes the pore of the channel. This information will be of interest to biochemists, cell biologists and biophysicists interested in the function of gap-junction channels in health and disease.

   Reviewed by eLife

4. Inhibition of mitochondrial protein import and proteostasis by a pro-apoptotic lipid

   This article has 7 authors:

   1. Josep Fita-Torró
   2. José Luis Garrido-Huarte
   3. Lucía López-Gil
   4. Agnès H Michel
   5. Benoit Kornmann
   6. Amparo Pascual-Ahuir
   7. Markus Proft

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study is a valuable observation that deals with the toxic effects of an intermediary in lipid degradation [trans-2-hexadecenal (t-2-hex)] in yeast through modification of mitochondrial protein import via the TOM complex. We find that the claim that the TOM complex is a main target of t-2-hex are supported by solid evidence, however the molecular mechanism remains unclear allowing multiple interpretation. Despite the shortcomings, this study is inspiring for researchers from the organellar, protein trafficking and lipid field and serves as a starting point to further precise and mechanistic analyses of the phenomenon.

   Reviewed by eLife

5. Human DDX6 regulates translation and decay of inefficiently translated mRNAs

   This article has 2 authors:

   1. Ramona Weber
   2. Chung-Te Chang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides valuable findings that improve our understanding of the evolutionary conservation of the role of DDX6 in mRNA decay. The evidence supporting the authors' conclusions is convincing. This work will be of interest to molecular, cell biologists and biochemists, especially those studying RNA.

   Reviewed by eLife

6. Involvement of TRPV4 in temperature-dependent perspiration in mice

   This article has 7 authors:

   1. Makiko Kashio
   2. Sandra Derouiche
   3. Reiko U Yoshimoto
   4. Kenji Sano
   5. Jing Lei
   6. Mizuho A Kido
   7. Makoto Tominaga

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This useful studying implicates TRPV4 as a mediator of sweat, potentially based on TRPV4's expression and function on sweat glands. The data and methods are solid, with some limitations in terms of the approach. Overall, the work lends new insight into the physiologic basis of sweating using data from mice and humans.

   Reviewed by eLife

7. Delivery of a Jagged1-PEG-MAL hydrogel with pediatric human bone cells regenerates critically sized craniofacial bone defects

   This article has 15 authors:

   1. Archana Kamalakar
   2. Brendan Tobin
   3. Sundus Kaimari
   4. M Hope Robinson
   5. Afra I Toma
   6. Timothy Cha
   7. Samir Chihab
   8. Irica Moriarity
   9. Surabhi Gautam
   10. Pallavi Bhattaram
   11. Shelly Abramowicz
   12. Hicham Drissi
   13. Andres Garcia
   14. Levi Wood
   15. Steven L Goudy

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Therapeutic treatments for congenital and acquired craniofacial (CF) bone abnormalities are not well developed. This study provides convincing evidence for an innovative regenerative treatment for pediatric craniofacial bone loss using Jagged1-PEG-MAL hydrogel with pediatric human bone cells. The report is a valuable advance in this field.

   Reviewed by eLife

8. 7,8-Dihydroxyflavone is a direct inhibitor of human and murine pyridoxal phosphatase

   This article has 12 authors:

   1. Marian Brenner
   2. Christoph Zink
   3. Linda Witzinger
   4. Angelika Keller
   5. Kerstin Hadamek
   6. Sebastian Bothe
   7. Martin Neuenschwander
   8. Carmen Villmann
   9. Jens Peter von Kries
   10. Hermann Schindelin
   11. Elisabeth Jeanclos
   12. Antje Gohla

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Following small molecule screens, this study provides convincing evidence that 7,8 dihydroxyflavone (DHF) is a competitive inhibitor of pyridoxal phosphatase. These results are important since they offer an alternative mechanism for the effects of 7,8 dihdroxyflavone in cognitive improvement in several mouse models. This paper is also significant due to the interest in the phosphatases and neurodegeneration fields.

   Reviewed by eLife

9. The delayed kinetics of Myddosome formation explains why amyloid-beta aggregates trigger Toll-like receptor 4 less efficiently than lipopolysaccharide

   This article has 6 authors:

   1. Bing Li
   2. Prasanna Suresh
   3. Jack Brelstaff
   4. Shekhar Kedia
   5. Clare E Bryant
   6. David Klenerman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study uses a novel light sheet imaging technique to investigate how different TLR4 agonists regulate Myddosome formation. The data showing that LPS and A-beta can control the kinetics and size of Myddosome assembly are compelling. This paper should be of substantial interest to the innate immunity field.

   Reviewed by eLife

10. Agent-based model demonstrates the impact of nonlinear, complex interactions between cytokines on muscle regeneration

    This article has 5 authors:

    1. Megan Haase
    2. Tien Comlekoglu
    3. Alexa Petrucciani
    4. Shayn M Peirce
    5. Silvia S Blemker

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This is so-far the most comprehensive, spatially resolved in 2D, dynamical, multicellular model of murine muscle regeneration after injury. The work is an attempt to combine many contributors to muscle regeneration into one coherent calibrated framework. The presented analysis is solid and the model has the potential to be a very valuable tool in the areas of tissue morphogenesis, regenerative therapies, quantitative modeling and simulation.

    Reviewed by eLife