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   10.1101/2024.04.15.589628

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   10.1101/2023.07.13.548866

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   10.21203/rs.3.rs-2380259/v1

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   10.1101/2024.02.27.582302

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   10.1101/2024.01.31.578214

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   10.1101/2023.08.19.553999

8. The TTLL10 polyglycylase is stimulated by tubulin glutamylation and inhibited by polyglycylation

   This article has 5 authors:

   1. Steven W Cummings
   2. Yan Li
   3. Jeffrey O Spector
   4. Christopher Kim
   5. Antonina Roll-Mecak

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In their study, Cummings et al. provide a valuable advance in understanding the hierarchical regulation of tubulin polyglycylation, demonstrating that TTLL8 initiates monoglycylation which is a prerequisite for TTLL10-mediated polyglycylation. The evidence supporting these mechanistic insights is solid, relying on a compelling combination of purified biochemical assays, mass spectrometry, and microscopy. The work is further valued for revealing an unexpected crosstalk between polyglycylation and polyglutamylation that ensures a balanced post-translational modification landscape for proper cilia function.

   Reviewed by eLife

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   10.1101/2023.12.04.569989

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    10.1101/263681