eLife

Latest preprint reviews

1. Cardiac neurons expressing a glucagon-like receptor mediate cardiac arrhythmia induced by high-fat diet in Drosophila

   This article has 4 authors:

   1. Yunpo Zhao
   2. Jianli Duan
   3. Joyce van de Leemput
   4. Zhe Han

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study reports useful information on the mechanisms by which a high-fat diet induces arrhythmias in the model organism Drosophila. Specifically, the authors propose that adipokinetic hormone (Akh) secretion is increased with this diet, and through binding of Akh to its receptor on cardiac neurons, arrhythmia is induced. The authors have revised their manuscript, but in some areas the evidence remains incomplete, which the authors say future studies will be directed to closing the present gaps. Nonetheless, the data presented will be helpful to those who wish to extend the research to a more complex model system, such as the mouse.

   Reviewed by eLife

2. The satiety hormone cholecystokinin gates reproduction in fish by controlling gonadotropin secretion

   This article has 9 authors:

   1. Lian Hollander-Cohen
   2. Omer Cohen
   3. Miriam Shulman
   4. Tomer Aiznkot
   5. Pierre Fontanaud
   6. Omer Revah
   7. Patrice Mollard
   8. Matan Golan
   9. Berta Levavi-Sivan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents valuable findings on the role of the satiety hormone cholecystokinin typically associated with feeding in the control of a pituitary hormone, FSH, which is a critical regulator of reproductive physiology. The authors provide solid pharmacological evidence that cholecystokinin is sufficient to regulate FSH and compelling genetic evidence that one of its receptors is required for gonadal development, with uncertainties remaining about the physiological regulation and necessity of the peptide. The work will be of interest to reproductive biologists, especially those with an interest in the endocrine control of fertility.

   Reviewed by eLife

3. DIETS: a simple and sensitive assay to measure and control the intake of complex solid foods, like high-fat diets, in Drosophila

   This article has 7 authors:

   1. Manikrao R. Thakare
   2. Prerana Choudhary
   3. Bhavna Pydah
   4. Suhas Sunke
   5. R Sai Prathap Yadav
   6. Pavan Agrawal
   7. Gaurav Das

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment:

     This work describes an easily implemented method for measuring solid food intake in Drosophila, which is necessary for studying the consumption of experimentally challenging diets, such as high-fat foods, as well as their nutritional impacts on the organism. It is a valuable technical contribution with solid evidence supporting the conclusions, filling a significant gap in the field.

   Reviewed by eLife

4. Estradiol elicits distinct firing patterns in arcuate nucleus kisspeptin neurons of females through altering ion channel conductances

   This article has 9 authors:

   1. Jian Qiu
   2. Margaritis Voliotis
   3. Martha A Bosch
   4. Xiao Feng Li
   5. Larry S Zweifel
   6. Krasimira Tsaneva-Atanasova
   7. Kevin T O'Byrne
   8. Oline K Rønnekleiv
   9. Martin J Kelly

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study combined multiple approaches to gain insight into why rising estradiol levels, by influencing hypothalamic neurons, ultimately lead to ovulation. The experimental data were solid, but evidence for the conclusion that the findings explain how estradiol acts in the intact female were incomplete because they lacked experimental conditions that better approximate physiological conditions. Nevertheless the work will be of interest to reproductive biologists working on ovarian biology and female fertility.

   Reviewed by eLife

5. Binding of LncDACH1 to dystrophin impairs the membrane trafficking of Nav1.5 protein and increases ventricular arrhythmia susceptibility

   This article has 21 authors:

   1. Genlong Xue
   2. Jiming Yang
   3. Yang Zhang
   4. Ying Yang
   5. Ruixin Zhang
   6. Desheng Li
   7. Tao Tian
   8. Jialiang Li
   9. Xiaofang Zhang
   10. Changzhu Li
   11. Xingda Li
   12. Jiqin Yang
   13. Kewei Shen
   14. Yang Guo
   15. Xuening Liu
   16. Guohui Yang
   17. Lina Xuan
   18. Hongli Shan
   19. Yanjie Lu
   20. Yang Baofeng
   21. Zhenwei Pan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents an important contribution to cardiac arrhythmia research by demonstrating long noncoding RNA Dachshund homolog 1 (lncDACH1) tunes sodium channel functional expression and affects cardiac action potential conduction and rhythms. The evidence supporting the major claims are convincing. The work will be of broad interest to cell biologists and cardiac electrophysiologists.

   Reviewed by eLife

6. The evolutionary history of the ancient weevil family Belidae (Coleoptera: Curculionoidea) reveals the marks of Gondwana breakup and major floristic turnovers, including the rise of angiosperms

   This article has 12 authors:

   1. Xuankun Li
   2. Adriana E Marvaldi
   3. Rolf G Oberprieler
   4. Dave Clarke
   5. Brian D Farrell
   6. Andrea Sequeira
   7. M Silvia Ferrer
   8. Charles O'Brien
   9. Shayla Salzman
   10. Seunggwan Shin
   11. William Tang
   12. Duane D McKenna

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Through anchored phylogenomic analyses, this important study offers fresh insights into the evolutionary history of the plant diet and geographic distribution of Belidae weevil beetles. Employing robust methodological approaches, the authors propose that certain belid lineages have maintained a continuous association with Araucaria hosts since the Mesozoic era. Although the biogeographical analysis is somewhat limited by uncertainties in vicariance explanations, this convincing study enhances our understanding of Belidae's evolutionary dynamics and provides new perspectives on ancient community ecology.

   Reviewed by eLife

7. Laminar specificity and coverage of viral-mediated gene expression restricted to GABAergic interneurons and their parvalbumin subclass in marmoset primary visual cortex

   This article has 6 authors:

   1. Frederick Federer
   2. Justin Balsor
   3. Alexander Ingold
   4. David P Babcock
   5. Jordane Dimidschstein
   6. Alessandra Angelucci

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Unlocking the potential of molecular genetic tools (optogenetics, chemogenetics, sensors, etc.) for the study of systems neuroscience in nonhuman primates requires the development of effective regulatory elements for cell-type specific expression to facilitate circuit dissection. This study provides a valuable building block, by carefully characterizing the laminar expression profile of two optogenetic enhancers, one designed for general GABA+ergic neurons (h56D) and the second (S5E2) for parvalbumin+ cell-type selective expression in the marmoset primary visual cortex. This study contributes solid evidence to our understanding of these tools but is limited by the understandably small number of animals used.

   Reviewed by eLife

8. Development of a new genotype–phenotype linked antibody screening system

   This article has 9 authors:

   1. Takashi Watanabe
   2. Hikaru Hata
   3. Yoshiki Mochizuki
   4. Fumie Yokoyama
   5. Tomoko Hasegawa
   6. Naveen Kumar
   7. Tomohiro Kurosaki
   8. Osamu Ohara
   9. Hidehiro Fukuyama

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The useful studies described here are broadly applicable to all antibody discovery subfields, even though they are not a significant improvement over published methods. The findings are incomplete with respect to the methodology, since details that are crucial in order to repeat the experiments are lacking (such as a timestamp). They also do not take into account multiple recent papers that have tested similar strategies. These studies will be of interest to a specialized audience working on generating antibodies to infectious agents.

   Reviewed by eLife

9. Evolution of hind limb morphology of Titanosauriformes (Dinosauria, Sauropoda) analyzed via 3D geometric morphometrics reveals wide-gauge posture as an exaptation for gigantism

   This article has 4 authors:

   1. Adrián Páramo
   2. Pedro Mocho
   3. Fernando Escaso
   4. Francisco Ortega

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors present convincing findings on trends in hind limb morphology through the evolution of titanosaurian sauropod dinosaurs, the land animals that reached the most remarkable gigantic sizes. The important results include the use of 3D geometric morphometrics to examine the femur, tibia, and fibula to provide new information on the evolution of this clade and on evolutionary trends between morphology and allometry.

   Reviewed by eLife

10. The PRC2.1 subcomplex opposes G1 progression through regulation of CCND1 and CCND2

    This article has 15 authors:

    1. Adam D Longhurst
    2. Kyle Wang
    3. Harsha Garadi Suresh
    4. Mythili Ketavarapu
    5. Henry N Ward
    6. Ian R Jones
    7. Vivek Narayan
    8. Frances V Hundley
    9. Arshia Zernab Hassan
    10. Charles Boone
    11. Chad L Myers
    12. Yin Shen
    13. Vijay Ramani
    14. Brenda J Andrews
    15. David P Toczyski

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This valuable study reports a chemogenetic screen for resistance and sensitivity to three cell cycle inhibitors used in the clinic: camptothecin, colchicine, and palbociclib. The screen provides a wealth of information that will be of interest to cell cycle and cancer biologists. Convincing evidence is provided that resistance to palbociclib can result from loss of PRC2.1 activity, which raises cyclin D levels. The effect of PRC2.1 on cyclin D is not universal across tested cell lines with the causal differences not yet understood.

    Reviewed by eLife